LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,474
تعداد دریافت فایل اصل مقاله11,291,245
Carneiro, Diego, da Silva, Michael, Vasconcelos, Karla Vanessa, Dias, Romero, Costa, Vanessa, Vasconcelos, Raquel, Carneiro, Bárbara, Barreto, Gisele, Marques, Mirna, Vasconcelos, Hellíada, Ribeiro Júnior, Howard, Gusmão, Jonas, da Silveira, Helson, Leitão, Renata, Brito, Gerly Anne, Pereira, Karuza Maria, Gondim, Delane, Goes, Paula. (1402). Chenopodium Ambrosioides Linn Mitigates Bone Loss in Rats with Periodontitis. سامانه مدیریت نشریات علمی, 25(1), 59-67. doi: 10.30476/dentjods.2023.95767.1891
Diego Thiers Oliveira Carneiro; Michael Douglas da Silva; Karla Vanessa Pinto Vasconcelos; Romero Dias; Vanessa Costa; Raquel Felipe Vasconcelos; Bárbara Carneiro; Gisele Barreto; Mirna Marques; Hellíada Chaves Vasconcelos; Howard Lopes Ribeiro Júnior; Jonas Nogueira Ferreira Maciel Gusmão; Helson da Silveira; Renata Leitão; Gerly Anne de Castro Brito; Karuza Maria Alves Pereira; Delane Viana Gondim; Paula Goes. "Chenopodium Ambrosioides Linn Mitigates Bone Loss in Rats with Periodontitis". سامانه مدیریت نشریات علمی, 25, 1, 1402, 59-67. doi: 10.30476/dentjods.2023.95767.1891
Carneiro, Diego, da Silva, Michael, Vasconcelos, Karla Vanessa, Dias, Romero, Costa, Vanessa, Vasconcelos, Raquel, Carneiro, Bárbara, Barreto, Gisele, Marques, Mirna, Vasconcelos, Hellíada, Ribeiro Júnior, Howard, Gusmão, Jonas, da Silveira, Helson, Leitão, Renata, Brito, Gerly Anne, Pereira, Karuza Maria, Gondim, Delane, Goes, Paula. (1402). 'Chenopodium Ambrosioides Linn Mitigates Bone Loss in Rats with Periodontitis', سامانه مدیریت نشریات علمی, 25(1), pp. 59-67. doi: 10.30476/dentjods.2023.95767.1891
Carneiro, Diego, da Silva, Michael, Vasconcelos, Karla Vanessa, Dias, Romero, Costa, Vanessa, Vasconcelos, Raquel, Carneiro, Bárbara, Barreto, Gisele, Marques, Mirna, Vasconcelos, Hellíada, Ribeiro Júnior, Howard, Gusmão, Jonas, da Silveira, Helson, Leitão, Renata, Brito, Gerly Anne, Pereira, Karuza Maria, Gondim, Delane, Goes, Paula. Chenopodium Ambrosioides Linn Mitigates Bone Loss in Rats with Periodontitis. سامانه مدیریت نشریات علمی, 1402; 25(1): 59-67. doi: 10.30476/dentjods.2023.95767.1891

Chenopodium Ambrosioides Linn Mitigates Bone Loss in Rats with Periodontitis

Journal of Dentistry
مقاله 8، دوره 25، شماره 1 - شماره پیاپی 82، خرداد 2024، صفحه 59-67    اصل مقاله (761.04 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2023.95767.1891
نویسندگان
Diego Thiers Oliveira Carneiro1؛ Michael Douglas da Silva1؛ Karla Vanessa Pinto Vasconcelos1؛ Romero Dias1؛ Vanessa Costa1؛ Raquel Felipe Vasconcelos1؛ Bárbara Carneiro2؛ Gisele Barreto1؛ Mirna Marques3؛ Hellíada Chaves Vasconcelos3؛ Howard Lopes Ribeiro Júnior1؛ Jonas Nogueira Ferreira Maciel Gusmão1؛ Helson da Silveira1؛ Renata Leitão1؛ Gerly Anne de Castro Brito1؛ Karuza Maria Alves Pereira1؛ Delane Viana Gondim1؛ Paula Goes* 4
1Dept. of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Brazil.
2Post Graduation Program of Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Brazil.
3Post Graduation Program in Health Science, School of Medicine, Federal University of Ceará, Sobral, Brazil.
4Dept. of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Brazil.
چکیده
Statement of the Problem: Periodontitis is an inflammatory disease that causes bone loss. Some patients do not respond well to the classic treatment and need therapies that minimize bone loss, the main sequel of the disease. Chenopodium ambrosioides L. has stood out due to its anti-inflammatory and anti-oxidative activities. However, no study has yet investigated its effect on periodontitis.
Purpose: This study aimed to evaluate the bone protective effect of Chenopodium ambrosioides L. (CAL) extract on ligature-induced periodontitis model in rats.
Materials and Method: For this, a pre-clinical assay was performed, using male Wistar rats divided into 3 groups: Naive (N) (n=6), not submitted to any procedure; Saline (SAL) (n=6), submitted to ligature-induced periodontitis and receiving 2 ml/kg of 0.9% saline solution; and CAL extract, which was subdivided into 3 subgroups (n=6/subgroup) receiving the CAL at 3 (CAL3), 10 (CAL10) or 30 mg/kg (CAL30). All agents were given, by oral gavage, 30 min before periodontitis induction and daily until euthanasia (11th day). By then, maxillae were removed for macroscopic, histological, and histometric analyses. Kidneys, liver, and stomach were collected to evaluate the safety of CAL extract. High-performance liquid chromatography (HPLC) assay was used to investigate the flavonoid content in the extract. 
Results: Chenopodium ambrosioides L. extract at 30mg/kg showed a reduction by 58% in bone loss marked by an increase (+35%) in the number of osteoblasts and a reduction (-51%) on the number of osteoclasts (p< 0.05). No significant alteration in the liver, kidney, or stomach was seen. Rutin was the main flavonoid found.
Conclusion: In summary, it was observed that Chenopodium ambrosioides L. extract has shown important anti-inflammatory and bone anabolic and anti-resorptive properties without causing toxicity in the main organs. Rutin, as the main flavonoid of the extract, seems to be responsible for the beneficial effect of this agent.

تازه های تحقیق

Paula Goes (Google Scholar)

کلیدواژه‌ها
Periodontitis؛ Inflammation؛ Chenopodium ambrosioides؛ Flavonoids؛ Rutin
سایر فایل های مرتبط با مقاله
مراجع
  • Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017; 3: 17038.
  • Cobb CM, Sottosanti JS. A re-evaluation of scaling and root planing. J Periodontol. 2021; 92: 1370-1378.
  • Donos N, Calciolari E, Brusselaers N, Goldoni M, Bostanci N, Belibasakis GN. The adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo-controlled clinical studies. J Clin Periodontol. 2020; 47 Suppl 22:199-238.
  • Moghadam ET, Yazdanian M, Tahmasebi E, Tebyanian H, Ranjbar R, Yazdanian A, et al. Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies. Eur J Pharmacol. 2020; 889: 173665.
  • Reyes-Becerril M, Angulo C, Sanchez V, Vázquez-Martínez J, López MG. Antioxidant, intestinal immune status and anti-inflammatory potential of Chenopodium ambrosioides in fish: In vitro and in vivo studies. Fish Shellfish Immunol. 2019; 86: 420-428.
  • Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK. Extraction optimization, total phenolic, flavonoid contents, HPLC-DAD analysis and diverse pharmacological evaluations of Dysphania ambrosioides (L.) Mosyakin & Clemants. Nat Prod Res. 2019; 33: 136-142. 
  • Soares CD, Carvalho GFD, Carvalho RA, Trindade SRPT, Rego ACM, Filho IA, et al. Chenopodium ambro-sioides extract prevents bone loss. Acta Cirúrgica Bra-sileira. 2015; 30: 812-818.
  • Pereira WS, da*Silva GP, Vigliano MV, Leal NRF, Pinto FA, Fernandes DC, et al. Anti-arthritic properties of crude extract from Chenopodium ambrosioides leaves. J Pharm Pharmacol. 2018; 70: 1078-1091.
  • Penha ESD, Lacerda-Santos R, Carvalho MGF, Oliveira PT. Effect of Chenopodium ambrosioides on the healing process of the in vivo bone tissue. Microsc Res Tech. 2017; 80: 1167-1173.
  • Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG. NC3Rs Reporting Guidelines Working Group. Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol. 2010; 160: 1577-1579. 
  • Goes P, Lima AP, Melo IM, Rêgo RO, Lima V. Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats. Braz Dent J. 2010; 21: 193-198.
  • Patrício FJ, Costa GC, Pereira PVS, Aragão-Filho WC, Sousa SM, Frazão JB, et al. Efficacy of the intralesional treatment with Chenopodium ambrosioides in the murine infection by Leishmania amazonenses. J Ethnopharmacol. 2008; 115: 313-319.
  • Assaidi A, Legssyer A, Berrichi A, Aziz M, Mekhfi H, Bnouham M, et al. Hypotensive property of Chenopodium ambrosioides in anesthetized normotensive rats. J Complement Integr Med. 2004; 11: 1-7.
  • Calado GP, Lopes AJO, Costa Junior LM, Lima FdCA, Silva LA, Pereira WS. Chenopodium ambrosioides Reduces Synovial Inflammation and Pain in Experimental Osteoarthritis. PLoS One. 2015; 10: 1-18.
  • Silva MGC, Amorim NL, Câmara CC, Neto JDF, Blanco BS. Acute and Sub-Chronic Toxicity of Aqueous Extracts of Chenopodium ambrosioides Leaves in Rats. J Med Food. 2014; 17: 979-984.
  • Leitão RFC, Ribeiro RA, Chaves HV, Rocha FAC, Lima V, Brito GAC. Nitric Oxide Synthase Inhibition Prevents Alveolar Bone Resorption in Experimental Periodontitis in Rats. J Periodontol. 2005; 76: 956-963.
  • Goes P, Dutra C, Lösser L, Houfbauer LC, Rauner M, Thiele S. Loss of Dkk-1 in osteocytes mitigates alveolar bone loss in mice with periodontitis. Front Immunol. 2019; 10: 1-8.
  • Ribeiro KA, Chaves HV, Filho SMP, Pinto IR, Monteiro DAM, Matos SO, et al. Alpha-2 Adrenergic and Opioids Receptors Participation in Mice Gastroprotection of Abelmoschus esculentus Curr Pharm Des. 2016; 22: 4736-4742.
  • Pinto IR, Chaves HV, Vasconcelos AS, Sousa FCF, Gadelha TS, Lacerda JTJG, et al. Antiulcer and Antioxidant Activity of a Lectin from Mucuna pruriens Seeds on Ethanol-induced Gastropathy: Involvement of Alpha-2 Adrenoceptors and Prostaglandins. Curr Pharm Des. 2019; 25: 1430-1439.
  • Jesus RS, Piana M, Freitas RB, Brum TF, Alves CFS, Belke BV, et al. In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides Braz J Microbiol. 2018; 49: 296-302.
  • Nedialkova ZK, Nedialkov PT, Nikolov SD. The genus chenopodium: phytochemistry ethnopharmacology and pharmacology.Pharmacogn  2009; 3: 280–306.
  • Grassi LT, Malheiros A, Silva CZ. From popular use to pharmacological validation: a study of the anti-inflammatory anti-nociceptive and healing effects ofChenopodium ambrosioides  J Ethnopharmacol. 2013; 145: 127-138.
  • BRASIL Ministério da Saúde Organização Mundial da Saúde. Available at: http://bvsmssaudegovbr/bvs/sus/pdf/marco/ms_relacao_plantas_medicinais_sus_0603pdf; 2009.
  • Liu XW, Ma B, Zi Y, Xiang LB, Han TY. Effects of rutin on osteoblast MC3T3-E1 differentiation, ALP activity and Runx2 protein expression. Eur J Histochem. 2021; 65: 3195.
  • Zhao B, Xiong Y, Zhang Y, Jia L, Zhang W, Xu X. Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/ mTOR signaling pathway. Exp Biol Med (May wood). 2020; 245: 552-561.
  • Hyun H, Park H, Jeong J, Kim J, Kim H, Oh HI, et al. Effects of Watercress Containing Rutin and Rutin Alone on the Proliferation and Osteogenic Differentiation of Human Osteoblast-like MG-63 Cells. Korean J Physiol Pharmacol. 2014; 18: 347-352.
  • Abdel-Naim AB, Alghamdi AA, Algandaby MM, Al-Abbasi FA, Al-Abd AM, Eid BG, et al. Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers. Oxid Med Cell Longev. 2018; 2018: 5106469.
  • Lee NK, Choi YG, Baik JY, Han SY, Jeong D, Bae YS, et al. Acrucial role for reactive oxygen species in RANK-L-inducedosteoclast differentiation. Blood. 2005; 106: 852-859.
  • Pan W, Wang Q, Chen Q. The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci. 2019; 11: 30.
  • Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, et al. Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Arch Oral Biol. 2008; 53: 1113-1118.
  • Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids. 1987; 45: 337–351.
  • Lin P, Niimi H, Ohsugi Y, Tsuchiya Y, Shimohira T, Komatsu K, et al. Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease. Int J Mol Sci. 2021; 22: 8900.
آمار
تعداد مشاهده مقاله: 3,120
تعداد دریافت فایل اصل مقاله: 445


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب