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Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. (1402). Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review. سامانه مدیریت نشریات علمی, 20(2), 232-239. doi: 10.22034/iji.2023.97452.2513
Liang Hua; Dongjie Guo; Xin Liu; Jiaqi Jiang; Qian Wang; Yi Wang; Te Liu; Fulun Li. "Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review". سامانه مدیریت نشریات علمی, 20, 2, 1402, 232-239. doi: 10.22034/iji.2023.97452.2513
Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. (1402). 'Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review', سامانه مدیریت نشریات علمی, 20(2), pp. 232-239. doi: 10.22034/iji.2023.97452.2513
Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review. سامانه مدیریت نشریات علمی, 1402; 20(2): 232-239. doi: 10.22034/iji.2023.97452.2513

Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review

Iranian Journal of Immunology
مقاله 9، دوره 20، شماره 2، شهریور 2023، صفحه 232-239    اصل مقاله (602.15 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.22034/iji.2023.97452.2513
نویسندگان
Liang Hua1؛ Dongjie Guo1؛ Xin Liu1؛ Jiaqi Jiang2؛ Qian Wang3؛ Yi Wang1؛ Te Liu4؛ Fulun Li* 1
1Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
3Department of Pathology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
4Laboratory of Basic Medicine, Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
چکیده
Individuals with Selective Immunoglobulin-A Deficiency (SIgAD) are often asymptomatic, and symptomatic SIgAD patients often have autoimmune comorbidities. A 48-year-old Han Chinese man presented with abdominal discomfort, hematochezia, and a large tumor in the anogenital region. The primary diagnosis of SIgAD was based on the patient’s age, serum IgA concentration (0.067 g/L), and the evidence of chronic respiratory infection. No other immunoglobulin deficiency or evidence of immunosuppression was present. The primary diagnosis of giant condyloma acuminatum was based on human papilloma virus-6-positive laboratory results and histological characteristics. The tumor and adjacent skin lesions were resected. Hemoglobin concentration fell to 5.50 g/dL, and an emergency erythrocyte transfusion was performed. The body temperature increased to 39.8 ºC, suggesting a transfusion reaction, and 5 mg dexamethasone was administered intravenously. Hemoglobin concentration stabilized at 10.5 g/dL. The clinical signs and laboratory results indicated autoimmune hemolytic anemia, systemic lupus erythematosus, and Hashimoto’s thyroiditis. Abdominal discomfort and hematochezia subsided. Though uncommon, the manifestation of multiple autoimmune comorbidities can occur in SIgAD patients. Further research is needed regarding the causes of SIgAD and the autoimmune disorders that often occur as comorbidities.
کلیدواژه‌ها
Autoimmune Disorder؛ Comorbidity؛ Giant Condyloma Acuminatum؛ Selective IgA Deficiency
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