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Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. (1402). Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review. سامانه مدیریت نشریات علمی, 20(2), 232-239. doi: 10.22034/iji.2023.97452.2513
Liang Hua; Dongjie Guo; Xin Liu; Jiaqi Jiang; Qian Wang; Yi Wang; Te Liu; Fulun Li. "Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review". سامانه مدیریت نشریات علمی, 20, 2, 1402, 232-239. doi: 10.22034/iji.2023.97452.2513
Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. (1402). 'Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review', سامانه مدیریت نشریات علمی, 20(2), pp. 232-239. doi: 10.22034/iji.2023.97452.2513
Hua, Liang, Guo, Dongjie, Liu, Xin, Jiang, Jiaqi, Wang, Qian, Wang, Yi, Liu, Te, Li, Fulun. Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review. سامانه مدیریت نشریات علمی, 1402; 20(2): 232-239. doi: 10.22034/iji.2023.97452.2513

Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review

Iranian Journal of Immunology
مقاله 9، دوره 20، شماره 2، شهریور 2023، صفحه 232-239    اصل مقاله (602.15 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.22034/iji.2023.97452.2513
نویسندگان
Liang Hua1؛ Dongjie Guo1؛ Xin Liu1؛ Jiaqi Jiang2؛ Qian Wang3؛ Yi Wang1؛ Te Liu4؛ Fulun Li* 1
1Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
3Department of Pathology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
4Laboratory of Basic Medicine, Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
چکیده
Individuals with Selective Immunoglobulin-A Deficiency (SIgAD) are often asymptomatic, and symptomatic SIgAD patients often have autoimmune comorbidities. A 48-year-old Han Chinese man presented with abdominal discomfort, hematochezia, and a large tumor in the anogenital region. The primary diagnosis of SIgAD was based on the patient’s age, serum IgA concentration (0.067 g/L), and the evidence of chronic respiratory infection. No other immunoglobulin deficiency or evidence of immunosuppression was present. The primary diagnosis of giant condyloma acuminatum was based on human papilloma virus-6-positive laboratory results and histological characteristics. The tumor and adjacent skin lesions were resected. Hemoglobin concentration fell to 5.50 g/dL, and an emergency erythrocyte transfusion was performed. The body temperature increased to 39.8 ºC, suggesting a transfusion reaction, and 5 mg dexamethasone was administered intravenously. Hemoglobin concentration stabilized at 10.5 g/dL. The clinical signs and laboratory results indicated autoimmune hemolytic anemia, systemic lupus erythematosus, and Hashimoto’s thyroiditis. Abdominal discomfort and hematochezia subsided. Though uncommon, the manifestation of multiple autoimmune comorbidities can occur in SIgAD patients. Further research is needed regarding the causes of SIgAD and the autoimmune disorders that often occur as comorbidities.
کلیدواژه‌ها
Autoimmune Disorder؛ Comorbidity؛ Giant Condyloma Acuminatum؛ Selective IgA Deficiency
مراجع
  1. Swain S, Selmi C, Gershwin ME, Teuber SS. The clinical implications of selective IgA deficiency. J Transl Autoimmun. 2019; 2:100025.
  2. Kanoh T, Mizumoto T, Yasuda N, Koya M, Ohno Y, Uchino H, et al. Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis 1. Vox Sang. 1986; 50:81-86.
  3. Odineal DD, Gershwin ME. The epidemiology and clinical manifestations of autoimmunity in selective IgA deficiency. Clin Rev Allergy Immunol. 2020; 58:107-133.
  4. Feng ML, Zhao YL, Shen T, Huang H, Yin B, Liu RZ, et al. Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk. Transfus Med. 2011; 21:338-343.
  5. Ezeoke A. Selective IgA deficiency (SIgAD) in Eastern Nigeria. Afr J Med Med Sci. 1988; 17:17-21.
  6. Modell V, Quinn J, Orange J, Notarangelo LD, Modell F. Primary immunodeficiencies worldwide: an updated overview from the Jeffrey Modell Centers Global Network. Immunol Res. 2016; 64:736-753.
  7. Wells J, McNally M, King M. Selective IgA deficiency in Australian blood donors. Aust N Z J Med. 1980; 10:410-413.
  8. Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, et al. Cancer in primary immunodeficiency diseases: cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018; 141:1028-1035.
  9. Mellemkjaer L, Hammarström L, Andersen V, Yuen J, Heilmann C, Barington T, et al. Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol. 2002; 130:495-500.
  10. Morawska I, Kurkowska S, Bębnowska D, Hrynkiewicz R, Becht R, Michalski A, et al. The epidemiology and clinical presentations of atopic diseases in selective IgA deficiency. J Clin Med. 2021; 10:3809.
  11. Ludvigsson JF, Neovius M, Ye W, Hammarström L. IgA deficiency and risk of cancer: a population-based matched cohort study. J Clin Immunol. 2015; 35:182-188.
  12. Zhang J, Kong W, Ni J, Guo Z, Yang X, Cao Q, et al. The epidemiology and clinical feature of selective immunoglobulin a deficiency of Zhejiang Province in China. J Clin Lab Anal. 2020; 34:e23440.
  13. Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020; 17:864.
  14. Spinu D, Radulescu A, Bratu O, Checherita IA, Ranetti AE, Mischianu D. Giant condyloma acuminatum - Buschke-Lowenstein disease - a literature review. Chirurgia (Bucur). 2014; 109:445-450.
  15. Sarmiento E, Mora R, Rodríguez-Mahou M, Rodríguez-Molina J, Fernández-Cruz E, Carbone J. Autoimmune disease in primary antibody deficiencies. Allergol Immunopathol (Madr). 2005; 33:69-73.
  16. Abolhassani H, Gharib B, Shahinpour S, Masoom S, Havaei A, Mirminachi B, et al. Autoimmunity in patients with selective IgA deficiency. J Investig Allergol Clin Immunol. 2015; 25:112-119.
  17. Azizi G, Tavakol M, Rafiemanesh H, Kiaee F, Yazdani R, Heydari A, et al. Autoimmunity in a cohort of 471 patients with primary antibody deficiencies. Expert Rev Clin Immunol. 2017; 13:1099-1106.
  18. Ludvigsson JF, Neovius M, Hammarström L. Association between IgA deficiency & other autoimmune conditions: a population-based matched cohort study. J Clin Immunol. 2014; 34:444-451.
  19. Erkoçoğlu M, Metin A, Kaya A, Özcan C, Akan A, Civelek E, et al. Allergic and autoimmune disorders in families with selective IgA deficiency. Turk J Med Sci. 2017; 47:592-598.
  20. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey‐Goldman R, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritis Rheumatol. 2019; 71:1400-1412.
  21. Covas MI, Esquerda A, García-Rico A, Mahy N. Peripheral blood T-lymphocyte subsets in autoimmune thyroid disease. J Investig Allergol Clin Immunol. 1992; 2:131-135.
  22. Younossi ZM, Bernstein D, Shiffman ML, Kwo P, Kim WR, Kowdley KV, et al. Diagnosis and management of primary biliary cholangitis. Am J Gastroenterol. 2019; 114:48-63.
  23. Hammarström L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol. 2000; 120:225-231.
  24. Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007; 27:308-316.
  25. Yazdani R, Azizi G, Abolhassani H, Aghamohammadi A. Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management. Scand J Immunol. 2017; 85:3-12.
  26. Kasi A, Hentzen S, Gupta N, Poddutoori P, Madan R, Anant S, et al. Immunoglobin A Deficiency and Squamous Cell Carcinoma With a Rare Presentation as Anal Cancer. J Med Cases. 2022; 13:26-30.
  27. Alvarez J, Garip E, Benitez M, Guzman L. 548 Immunoglobulin a Deficiency, HPV and Oral Cancer. World Allergy Organ J. 2012; 5:S191-S191.
  28. Ameratunga R, Longhurst H, Lehnert K, Steele R, Edwards ES, Woon S-T. Are All Primary Immunodeficiency Disorders Inborn Errors of Immunity? Front Immunol. 2021:2361.
  29. Cunningham-Rundles C, Fotino M, Rosina O, Peter J. Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex. Clin Immunol Immunopathol. 1991; 61:S61-S69.
  30. Wang N, Lu P, Ling B, Zhu Z, Hammarström L. Caucasian origin of disease associated HLA haplotypes in chinese blood donors with IgA deficiency. J Clin Immunol. 2014; 34:157-162.
  31. Rawla P, Killeen RB, Joseph N. IgA Deficiency. StatPearls [Internet]: StatPearls Publishing; 2022.
  32. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet. 2005; 37:829-834.
  33. Zhang J, van Oostrom D, Li J, Savelkoul HF. Innate mechanisms in selective IgA deficiency. Front Immunol. 2021; 12:649112.
  34. Amarilla M, Yotam E, Amit N. A genetic database and clinical findings for immunodeficiency due to mutations in interleukin-10, interleukin-10 receptor A, and interleukin-10 receptor B genes. LymphoSign Journal. 2017; 4:80-85.
  35. Mahdi BM. Role of HLA typing on Crohn's disease pathogenesis. Ann Med Surg (Lond). 2015; 4:248-253.
  36. Wang N, Shen N, Vyse TJ, Anand V, Gunnarson I, Sturfelt G, et al. Selective IgA deficiency in autoimmune diseases. Mol Med. 2011; 17:1383-1396.
  37. Wang N, Hammarström L. IgA deficiency: what is new? Curr Opin Allergy Clin Immunol. 2012; 12:602-608.
  38. Aghamohammadi A, Abolhassani H, Biglari M, Abolmaali S, Moazzami K, Tabatabaeiyan M, et al. Analysis of switched memory B cells in patients with IgA deficiency. Int Arch Allergy Immunol. 2011; 156:462-468.
  39. Rojas M, Restrepo-Jiménez P, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramírez-Santana C, et al. Molecular mimicry and autoimmunity. J Autoimmun. 2018; 95:100-123.
  40. Cusick MF, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol. 2012; 42:102-111.
  41. James SP, Jones EA, Schafer DF, Hoofnagle JH, Varma RR, Strober W. Selective immunoglobulin A deficiency associated with primary biliary cirrhosis in a family with liver disease. Gastroenterology. 1986; 90:283-288.
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