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Verma, Shailja, Joshi, Sanjay, Kothari, Vijay, Seshadri, Sriram. (1401). Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway. سامانه مدیریت نشریات علمی, 11(1), 15-21. doi: 10.30476/acrr.2023.97939.1174
Shailja Verma; Sanjay Joshi; Vijay Kothari; Sriram Seshadri. "Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway". سامانه مدیریت نشریات علمی, 11, 1, 1401, 15-21. doi: 10.30476/acrr.2023.97939.1174
Verma, Shailja, Joshi, Sanjay, Kothari, Vijay, Seshadri, Sriram. (1401). 'Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway', سامانه مدیریت نشریات علمی, 11(1), pp. 15-21. doi: 10.30476/acrr.2023.97939.1174
Verma, Shailja, Joshi, Sanjay, Kothari, Vijay, Seshadri, Sriram. Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway. سامانه مدیریت نشریات علمی, 1401; 11(1): 15-21. doi: 10.30476/acrr.2023.97939.1174

Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway

Iranian Journal of Colorectal Research
مقاله 2، دوره 11، شماره 1، خرداد 2023، صفحه 15-21    اصل مقاله (1.24 M)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2023.97939.1174
نویسندگان
Shailja Verma1، 2؛ Sanjay Joshi3؛ Vijay Kothari4؛ Sriram Seshadri* 1
1Institute of Science, Nirma University, Ahmedabad, India
2Department of R & D, National Foods, The Hing Research Center, GIDC-Waghodia, Vadodara, India
3National Foods-The Hing Research Centre, GIDC, Waghodia, Vadodara, India
4Institute of Science, Nirma University, Ahmedabad , India
چکیده
Purpose: The current investigation was conducted with the aim to elucidate and determine the anti-cancer efficacy in vitro on colon carcinoma human cell lines and to determine its probable mode of action.
Method: Anti-proliferative and apoptotic effect of various doses of essential oil from Ferula asafoetida was investigated on colon cancer cell lines i.e. CW620 and CT26. WT. The percentage cytotoxicity was determined by MTT assay. In addition, expression studies were carried out to determine the mode of action by determining the levels of NF-kB, TNF-alpha, TGF-beta and Caspases.
Result: The potent anti-proliferative activity has been observed in both the cell lines. The percentage cytotoxicity is directly proportional to the increasing concentration of the essential oil. The same was also confirmed in the expression studies which shows significant upregulation of the antiapoptotic characteristics and down regulation of pro-carcinogenic factors.
Conclusion: The essential oil shows potent anti-cancer activity and shows the role in gene regulation to attenuate the colon cancer.
کلیدواژه‌ها
Colon cancer؛ Ferula asafoetida؛ essential oil؛ anti-cancer properties؛ Caspases؛ Inflammation
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