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Momeni, Nastaran, Broomand, Mohammad Ali, Roozmand, Zahra, Hamzian, Nima. (1402). Estimating the Dose-Response Relationship for Ocular Pain after Radiotherapy of Head and Neck Cancers and Skull Base Tumors based on the LKB Radiobiological Model. سامانه مدیریت نشریات علمی, 13(5), 411-420. doi: 10.31661/jbpe.v0i0.2210-1554
Nastaran Momeni; Mohammad Ali Broomand; Zahra Roozmand; Nima Hamzian. "Estimating the Dose-Response Relationship for Ocular Pain after Radiotherapy of Head and Neck Cancers and Skull Base Tumors based on the LKB Radiobiological Model". سامانه مدیریت نشریات علمی, 13, 5, 1402, 411-420. doi: 10.31661/jbpe.v0i0.2210-1554
Momeni, Nastaran, Broomand, Mohammad Ali, Roozmand, Zahra, Hamzian, Nima. (1402). 'Estimating the Dose-Response Relationship for Ocular Pain after Radiotherapy of Head and Neck Cancers and Skull Base Tumors based on the LKB Radiobiological Model', سامانه مدیریت نشریات علمی, 13(5), pp. 411-420. doi: 10.31661/jbpe.v0i0.2210-1554
Momeni, Nastaran, Broomand, Mohammad Ali, Roozmand, Zahra, Hamzian, Nima. Estimating the Dose-Response Relationship for Ocular Pain after Radiotherapy of Head and Neck Cancers and Skull Base Tumors based on the LKB Radiobiological Model. سامانه مدیریت نشریات علمی, 1402; 13(5): 411-420. doi: 10.31661/jbpe.v0i0.2210-1554

Estimating the Dose-Response Relationship for Ocular Pain after Radiotherapy of Head and Neck Cancers and Skull Base Tumors based on the LKB Radiobiological Model

Journal of Biomedical Physics and Engineering
دوره 13، شماره 5، آذر و دی 2023، صفحه 411-420    اصل مقاله (1.07 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2210-1554
نویسندگان
Nastaran Momeni1؛ Mohammad Ali Broomand2؛ Zahra Roozmand1؛ Nima Hamzian* 1
1Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Clinical Oncology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
چکیده
Background: Radiotherapy is considered a compromise between the amount of killed tumor cells and the damage caused to the healthy tissue. Regarding this, radiobiological modeling is performed to individualize and optimize treatment strategies.
Objective: This study aimed to determine the normal tissue complication probability (NTCP) of acute ocular pain following radiotherapy.
Material and Methods: In this prospective observational study, the clinical data were collected from 45 patients with head and neck cancers and skull-base tumors, and dosimetric data were recorded after contouring the eye globe. Acute ocular pain was prospectively assessed with a three-month follow-up. The Lyman-Kutcher-Berman (LKB) parameters were estimated using the Area Under Curve (AUC) of Receiver Operating Characteristic (ROC) maximization and Maximum Likelihood (MLH) methods, and the NTCP of acute ocular pain was then determined using generalized LKB radiobiological model. The model performance was evaluated with AUC, Brier score, and Hosmer-Lemeshow tests.
Results: Six out of 45 (13.33%) patients developed acute ocular pain (grade 1 or more). LKB model showed a weak dose-volume effect (n=0.09), tolerance dose for a 50% complication (TD50) of 27.54 Gy, and slope parameter (m) of 0.38. The LKB model showed high prediction performance. The LKB model predicted that NTCP would be less than 25% if the generalized equivalent uniform dose (gEUD) was kept below 20 Gy. 
Conclusion: The LKB model showed a high performance in determining the NTCP of ocular pain so that the probability of ocular pain will be less than 25% if the eye globe mean dose is kept below 12 Gy.

تازه های تحقیق

Nastaran Momeni (Google Scholar)

Nima Hamzian (Google Scholar)

کلیدواژه‌ها
Normal Tissue Complication Probability؛ Dose-Response؛ Radiotherapy؛ Lyman-Kutcher-Burman؛ Ocular Pain
سایر فایل های مرتبط با مقاله
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