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Lin, Na, Xu, Liping, Dai, Qiaoding. (1401). Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases. سامانه مدیریت نشریات علمی, 20(1), 135-143. doi: 10.22034/iji.2023.93355.2218
Na Lin; Liping Xu; Qiaoding Dai. "Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases". سامانه مدیریت نشریات علمی, 20, 1, 1401, 135-143. doi: 10.22034/iji.2023.93355.2218
Lin, Na, Xu, Liping, Dai, Qiaoding. (1401). 'Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases', سامانه مدیریت نشریات علمی, 20(1), pp. 135-143. doi: 10.22034/iji.2023.93355.2218
Lin, Na, Xu, Liping, Dai, Qiaoding. Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases. سامانه مدیریت نشریات علمی, 1401; 20(1): 135-143. doi: 10.22034/iji.2023.93355.2218

Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases

Iranian Journal of Immunology
دوره 20، شماره 1، خرداد 2023، صفحه 135-143    اصل مقاله (1.22 M)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.22034/iji.2023.93355.2218
نویسندگان
Na Lin* ؛ Liping Xu؛ Qiaoding Dai
Rheumatology and Immunology department, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.
چکیده
Macrophage activation syndrome (MAS), a secondary hemophagocytic lymphohistiocytosis characterized by an excessive systemic inflammatory response, is a life-threatening and rare disease. Cardiovascular damage is a common and severe complication of the disease, however, it is easily ignored and not well studied. Herein, we report two cases of patients with MAS-associated heart damage and review the clinical characteristics, mechanism, and treatment. Case 1 along with systemic lupus erythematosus and Kikuchi necrotizing lymphadenitis occurred in fatal acute heart failure, and case 2 complicated adult-onset Still’s Disease began with atrial fibrillation and had some improvement with the treatment of high dose corticosteroids. MAS-associated heart damage is a critical issue in clinical settings, and the etiology and mechanisms of MAS-associated cardiovascular diseases are likely multifactorial. The manifestations were various and high levels of the cytokines and cardiac damage may contribute to poor prognosis. Therefore, early intensive immunosuppressive therapy probably improves the treatment outcome.
کلیدواژه‌ها
Cardiovascular Diseases؛ Case Report؛ Hemophagocytic Lymphohistiocytosis؛ Macrophage Activation Syndrome
مراجع
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