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Torkestani, Shirin, Zamani, Alireza, Mazdeh, Mehrdokht, Talebi-Ghane, Elahe, Roshanaie, Ghodratoallah, Eftekharian, Mohammad Mahdi. (1401). Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy. سامانه مدیریت نشریات علمی, 20(1), 104-113. doi: 10.22034/iji.2023.96695.2453
Shirin Torkestani; Alireza Zamani; Mehrdokht Mazdeh; Elahe Talebi-Ghane; Ghodratoallah Roshanaie; Mohammad Mahdi Eftekharian. "Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy". سامانه مدیریت نشریات علمی, 20, 1, 1401, 104-113. doi: 10.22034/iji.2023.96695.2453
Torkestani, Shirin, Zamani, Alireza, Mazdeh, Mehrdokht, Talebi-Ghane, Elahe, Roshanaie, Ghodratoallah, Eftekharian, Mohammad Mahdi. (1401). 'Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy', سامانه مدیریت نشریات علمی, 20(1), pp. 104-113. doi: 10.22034/iji.2023.96695.2453
Torkestani, Shirin, Zamani, Alireza, Mazdeh, Mehrdokht, Talebi-Ghane, Elahe, Roshanaie, Ghodratoallah, Eftekharian, Mohammad Mahdi. Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy. سامانه مدیریت نشریات علمی, 1401; 20(1): 104-113. doi: 10.22034/iji.2023.96695.2453

Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy

Iranian Journal of Immunology
دوره 20، شماره 1، خرداد 2023، صفحه 104-113    اصل مقاله (1.84 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.96695.2453
نویسندگان
Shirin Torkestani1؛ Alireza Zamani1؛ Mehrdokht Mazdeh2؛ Elahe Talebi-Ghane3؛ Ghodratoallah Roshanaie3؛ Mohammad Mahdi Eftekharian* 1، 4
1Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
2Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
3Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences.
4Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
چکیده
Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, as a costimulatory molecule and a TNF receptor superfamily member, has been demonstrated to have a key role in the pathogenesis of many autoimmune as well as inflammatory disorders.
Objective: To evaluate the transcripts levels of CD137, its ligand (CD137L), and the serum levels of soluble CD137 (sCD137) in patients with immune-mediated polyneuropathy.
Methods: A total of 45 patients and 46 sex and age-matched healthy individuals were enrolled in the study. CD137 and CD137L transcript levels were assessed by the Real-Time PCR, and the serum level of sCD137 was measured using the ELISA technique. The Bayesian regression model was used for statistical analysis at the 0.05 significance level in R 4.1.0 statistical environment.
Results: Transcript levels of the CD137 and CD137L were higher in polyneuropathy patients in comparison with the healthy subjects (P=0.006 for both). Conversely, the mean level of sCD137 was significantly lower in the sera of patients compared to the controls (P<0.001).
Conclusion: Our findings point to the possible role of CD137 and CD137L in immune-mediated polyneuropathy pathogenesis. More investigations are required to clarify the exact contributions of the mentioned molecules to the pathogenesis of immune-mediated polyneuropathies.
کلیدواژه‌ها
CD137 Antigen؛ Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Tumor Necrosis Factor Receptor Superfamily؛ sCD137
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