|تعداد مشاهده مقاله||10,670,154|
|تعداد دریافت فایل اصل مقاله||5,133,006|
Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy
|Iranian Journal of Immunology|
|دوره 20، شماره 1، خرداد 2023، صفحه 104-113 اصل مقاله (1.84 M)|
|نوع مقاله: Original Article|
|شناسه دیجیتال (DOI): 10.22034/iji.2023.96695.2453|
|Shirin Torkestani 1؛ Alireza Zamani 1؛ Mehrdokht Mazdeh 2؛ Elahe Talebi-Ghane 3؛ Ghodratoallah Roshanaie 3؛ Mohammad Mahdi Eftekharian 1، 4|
|1Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.|
|2Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.|
|3Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences.|
|4Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.|
|Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, as a costimulatory molecule and a TNF receptor superfamily member, has been demonstrated to have a key role in the pathogenesis of many autoimmune as well as inflammatory disorders.|
Objective: To evaluate the transcripts levels of CD137, its ligand (CD137L), and the serum levels of soluble CD137 (sCD137) in patients with immune-mediated polyneuropathy.
Methods: A total of 45 patients and 46 sex and age-matched healthy individuals were enrolled in the study. CD137 and CD137L transcript levels were assessed by the Real-Time PCR, and the serum level of sCD137 was measured using the ELISA technique. The Bayesian regression model was used for statistical analysis at the 0.05 significance level in R 4.1.0 statistical environment.
Results: Transcript levels of the CD137 and CD137L were higher in polyneuropathy patients in comparison with the healthy subjects (P=0.006 for both). Conversely, the mean level of sCD137 was significantly lower in the sera of patients compared to the controls (P<0.001).
Conclusion: Our findings point to the possible role of CD137 and CD137L in immune-mediated polyneuropathy pathogenesis. More investigations are required to clarify the exact contributions of the mentioned molecules to the pathogenesis of immune-mediated polyneuropathies.
|CD137 Antigen؛ Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Tumor Necrosis Factor Receptor Superfamily؛ sCD137|
تعداد مشاهده مقاله: 42
تعداد دریافت فایل اصل مقاله: 23