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Abu, Nadiah, Rus Bakarurraini, Nurul Ainaa Adilah, Nasir, Siti Nurmi, Ishak, Muhiddin, Baharuddin, Rashidah, Jamal, Rahman, Ab Mutalib, Nurul Syakima. (1401). Methylation Profile of Cancer Testis Antigens in Colorectal Cancer. سامانه مدیریت نشریات علمی, 20(1), 83-91. doi: 10.22034/iji.2023.92600.2171
Nadiah Abu; Nurul Ainaa Adilah Rus Bakarurraini; Siti Nurmi Nasir; Muhiddin Ishak; Rashidah Baharuddin; Rahman Jamal; Nurul Syakima Ab Mutalib. "Methylation Profile of Cancer Testis Antigens in Colorectal Cancer". سامانه مدیریت نشریات علمی, 20, 1, 1401, 83-91. doi: 10.22034/iji.2023.92600.2171
Abu, Nadiah, Rus Bakarurraini, Nurul Ainaa Adilah, Nasir, Siti Nurmi, Ishak, Muhiddin, Baharuddin, Rashidah, Jamal, Rahman, Ab Mutalib, Nurul Syakima. (1401). 'Methylation Profile of Cancer Testis Antigens in Colorectal Cancer', سامانه مدیریت نشریات علمی, 20(1), pp. 83-91. doi: 10.22034/iji.2023.92600.2171
Abu, Nadiah, Rus Bakarurraini, Nurul Ainaa Adilah, Nasir, Siti Nurmi, Ishak, Muhiddin, Baharuddin, Rashidah, Jamal, Rahman, Ab Mutalib, Nurul Syakima. Methylation Profile of Cancer Testis Antigens in Colorectal Cancer. سامانه مدیریت نشریات علمی, 1401; 20(1): 83-91. doi: 10.22034/iji.2023.92600.2171

Methylation Profile of Cancer Testis Antigens in Colorectal Cancer

Iranian Journal of Immunology
دوره 20، شماره 1، خرداد 2023، صفحه 83-91    اصل مقاله (1.08 M)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2023.92600.2171
نویسندگان
Nadiah Abu* ؛ Nurul Ainaa Adilah Rus Bakarurraini؛ Siti Nurmi Nasir؛ Muhiddin Ishak؛ Rashidah Baharuddin؛ Rahman Jamal؛ Nurul Syakima Ab Mutalib
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia.
چکیده
Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of cancers. The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer. Studies have indicated that the epigenetic regulation of the CTAs such as the methylation status may affect the expression of the CTAs. However, the report on the methylation status of the CTAs is conflicting. The general methylation profile of the CTAs, especially in colorectal cancer, is still elusive.
Objective: To determine the methylation profile of the selected CTAs in our colorectal cancer patients.
Methods: A total of 54 pairs of colorectal cancer samples were subjected to DNA methylation profiling using the Infinium Human Methylation 450K bead chip.
Results: We found that most of the CTAs were hypomethylated, and CCNA1 and TMEM108 genes were among the few CTAs that were hypermethylated.
Conclusion: Overall, our brief report has managed to show the overall methylation profile in over the 200 CTAs in colorectal cancer and this could be used for further refining any immunotherapy targets.
کلیدواژه‌ها
Cancer-testis Antigen؛ Cancer Vaccine؛ Epigenetics؛ Immunotherapy؛ Tumor-associated Antigen
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