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Sanaie, Sarvin, Dolati, Sanam, Montazer, Majid, Ranjbari, Sarina, Fathalizadeh, Arezoo, Shadvar, Kamran, Faramarzi, Elnaz, Mahmoodpoor, Ata. (1402). Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study. سامانه مدیریت نشریات علمی, 48(5), 465-473. doi: 10.30476/ijms.2022.95364.2672
Sarvin Sanaie; Sanam Dolati; Majid Montazer; Sarina Ranjbari; Arezoo Fathalizadeh; Kamran Shadvar; Elnaz Faramarzi; Ata Mahmoodpoor. "Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study". سامانه مدیریت نشریات علمی, 48, 5, 1402, 465-473. doi: 10.30476/ijms.2022.95364.2672
Sanaie, Sarvin, Dolati, Sanam, Montazer, Majid, Ranjbari, Sarina, Fathalizadeh, Arezoo, Shadvar, Kamran, Faramarzi, Elnaz, Mahmoodpoor, Ata. (1402). 'Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study', سامانه مدیریت نشریات علمی, 48(5), pp. 465-473. doi: 10.30476/ijms.2022.95364.2672
Sanaie, Sarvin, Dolati, Sanam, Montazer, Majid, Ranjbari, Sarina, Fathalizadeh, Arezoo, Shadvar, Kamran, Faramarzi, Elnaz, Mahmoodpoor, Ata. Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study. سامانه مدیریت نشریات علمی, 1402; 48(5): 465-473. doi: 10.30476/ijms.2022.95364.2672

Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study

Iranian Journal of Medical Sciences
مقاله 4، دوره 48، شماره 5، آذر 2023، صفحه 465-473    اصل مقاله (277.45 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.95364.2672
نویسندگان
Sarvin Sanaie1؛ Sanam Dolati2؛ Majid Montazer3؛ Sarina Ranjbari4؛ Arezoo Fathalizadeh4؛ Kamran Shadvar5؛ Elnaz Faramarzi6؛ Ata Mahmoodpoor* 1، 5
1Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Cardiothoracic Surgeries, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Anesthesiology and Critical Care Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to investigate the role of lipid profiles in determining the probability of organ dysfunction after surgery.
Methods: This cross-sectional study included patients who underwent thoracoabdominal surgery and were admitted to the intensive care unit of Imam Reza Hospital in Tabriz, Iran, between October 2016 and September 2018. During the first two days of admission, blood samples were taken, and serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and albumin were measured. The relation between the changes in these laboratory markers and six organ functions including cardiovascular, respiratory, renal, central nervous system, hepatic, and hematologic, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use were investigated. The independent t test was used to compare continuous variables. The association between different variables and organ dysfunction and mortality was evaluated by using logistic regression.
Results: The serum TC increased the risk of mortality (OR=1.09, 95%CI=1.06-1.11, P<0.001), renal dysfunction (OR=1.09, 95%CI=1.06-1.12; P<0.001), liver dysfunction (OR=1.07, 95%CI=1.03-1.10; P<0.001), respiratory dysfunction (OR=1.08, 95%CI=1.05-1.13; P<0.001). Moreover, LDL, HDL, and TG were found to be inversely related to mortality, organ dysfunction, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use. 
Conclusion: TC could be considered a risk factor for mortality, organ dysfunction, and clinical outcomes. On the other hand, LDL, HDL, and TG played a protective role in the patients’ mortality, organ dysfunction, and clinical outcomes.

تازه های تحقیق

Sarvin Sanaie (Google Scholar)

Ata Mahmoodpoor (Google Scholar)

کلیدواژه‌ها
Multiple organ failure؛ Cholesterol؛ Intensive care units؛ Mortality
سایر فایل های مرتبط با مقاله
مراجع
  1. Ulvik A, Kvale R, Wentzel-Larsen T, Flaatten H. Multiple organ failure after trauma affects even long-term survival and functional status. Crit Care. 2007;11:R95. doi: 10.1186/cc6111. PubMed PMID: 17784940; PubMed Central PMCID: PMCPMC2556737.
  2. Pettila V, Pettila M, Sarna S, Voutilainen P, Takkunen O. Comparison of multiple organ dysfunction scores in the prediction of hospital mortality in the critically ill. Crit Care Med. 2002;30:1705-11. doi: 10.1097/00003246-200208000-00005. PubMed PMID: 12163780.
  3. Schatz IJ, Masaki K, Yano K, Chen R, Rodriguez BL, Curb JD. Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study. Lancet. 2001;358:351-5. doi: 10.1016/S0140-6736(01)05553-2. PubMed PMID: 11502313.
  4. Delgado-Rodriguez M, Medina-Cuadros M, Martinez-Gallego G, Sillero-Arenas M. Total cholesterol, HDL-cholesterol, and risk of nosocomial infection: a prospective study in surgical patients. Infect Control Hosp Epidemiol. 1997;18:9-18. doi: 10.1086/647494. PubMed PMID: 9013240.
  5. Mizock BA. The multiple organ dysfunction syndrome. Dis Mon. 2009;55:476-526. doi: 10.1016/j.disamonth.2009.04.002. PubMed PMID: 19595297.
  6. Dunham CM, Fealk MH, Sever WE, 3rd. Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Crit Care. 2003;7:R145-53. doi: 10.1186/cc2382. PubMed PMID: 14624689; PubMed Central PMCID: PMCPMC374375.
  7. Chiarla C, Giovannini I, Giuliante F, Zadak Z, Vellone M, Ardito F, et al. Severe hypocholesterolemia in surgical patients, sepsis, and critical illness. J Crit Care. 2010;25:e7-12. doi: 10.1016/j.jcrc.2009.08.006. PubMed PMID: 19828282.
  8. Fraunberger P, Nagel D, Walli AK, Seidel D. Serum cholesterol and mortality in patients with multiple organ failure. Crit Care Med. 2000;28:3574-5. doi: 10.1097/00003246-200010000-00047. PubMed PMID: 11057826.
  9. Lekkou A, Mouzaki A, Siagris D, Ravani I, Gogos CA. Serum lipid profile, cytokine production, and clinical outcome in patients with severe sepsis. J Crit Care. 2014;29:723-7. doi: 10.1016/j.jcrc.2014.04.018. PubMed PMID: 24891152.
  10. Bonville DA, Parker TS, Levine DM, Gordon BR, Hydo LJ, Eachempati SR, et al. The relationships of hypocholesterolemia to cytokine concentrations and mortality in critically ill patients with systemic inflammatory response syndrome. Surg Infect (Larchmt). 2004;5:39-49. doi: 10.1089/109629604773860291. PubMed PMID: 15142422.
  11. Jin J, Shi Z, Pang X. Association between low-density lipoprotein cholesterol level and mortality in patients with cardiogenic shock: a retrospective cohort study. BMJ Open. 2021;11:e044668. doi: 10.1136/bmjopen-2020-044668. PubMed PMID: 34215599; PubMed Central PMCID: PMCPMC8256757.
  12. Tanaka S, Stern J, Bouzid D, Robert T, Dehoux M, Snauwaert A, et al. Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study. Ann Intensive Care. 2021;11:11. doi: 10.1186/s13613-021-00800-0. PubMed PMID: 33469739; PubMed Central PMCID: PMCPMC7815878.
  13. Lee SH, Lee JY, Hong TH, Kim BO, Lee YJ, Lee JG. Severe persistent hypocholesterolemia after emergency gastrointestinal surgery predicts in-hospital mortality in critically ill patients with diffuse peritonitis. PLoS One. 2018;13:e0200187. doi: 10.1371/journal.pone.0200187. PubMed PMID: 29979773; PubMed Central PMCID: PMCPMC6034864.
  14. Ko SH, Lee JS, Kim SK, Jeong KY. Serum cholesterol as a predictor of mortality among the elderly patients with pneumonia in the emergency department. Am J Emerg Med. 2021;45:404-9. doi: 10.1016/j.ajem.2020.09.012. PubMed PMID: 33039214.
  15. Wu Q, Zhong X, Fu M, Yang H, Bo H, Liao X, et al. High-density lipoprotein cholesterol to low-density lipoprotein cholesterol ratio in early assessment of disease severity and outcome in patients with acute pancreatitis admitted to the ICU. BMC Gastroenterol. 2020;20:164. doi: 10.1186/s12876-020-01315-x. PubMed PMID: 32460705; PubMed Central PMCID: PMCPMC7254649.
  16. Sviridov D, Remaley AT. High-density lipoprotein mimetics: promises and challenges. Biochem J. 2015;472:249-59. doi: 10.1042/BJ20150832. PubMed PMID: 26613945; PubMed Central PMCID: PMCPMC5606976.
  17. Cirstea M, Walley KR, Russell JA, Brunham LR, Genga KR, Boyd JH. Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis. J Crit Care. 2017;38:289-94. doi: 10.1016/j.jcrc.2016.11.041. PubMed PMID: 28013095.
  18. Peres Bota D, Melot C, Lopes Ferreira F, Nguyen Ba V, Vincent JL. The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction. Intensive Care Med. 2002;28:1619-24. doi: 10.1007/s00134-002-1491-3. PubMed PMID: 12415450.
  19. Rocker G, Cook D, Sjokvist P, Weaver B, Finfer S, McDonald E, et al. Clinician predictions of intensive care unit mortality. Crit Care Med. 2004;32:1149-54. doi: 10.1097/01.ccm.0000126402.51524.52. PubMed PMID: 15190965.
  20. Volpato S, Palmieri E, Fellin R, Zuliani G. Acute phase markers are associated with reduced plasma lipid levels in a population of hospitalized elderly patients. Gerontology. 2000;46:22-7. doi: 10.1159/000022129. PubMed PMID: 11111225.
  21. Onder G, Landi F, Volpato S, Fellin R, Carbonin P, Gambassi G, et al. Serum cholesterol levels and in-hospital mortality in the elderly. Am J Med. 2003;115:265-71. doi: 10.1016/s0002-9343(03)00354-1. PubMed PMID: 12967690.
  22. Kitazawa T, Yanagimoto S, Tatsuno K, Fukushima A, Okugawa S, Ota Y. Serum Cholesterol Levels at the Onset of Bloodstream Infection Have Prognostic Value. Advances in Infectious Diseases. 2012;2:100-5. doi: 10.4236/aid.2012.24017.
  23. Gui D, Spada PL, De Gaetano A, Pacelli F. Hypocholesterolemia and risk of death in the critically ill surgical patient. Intensive Care Med. 1996;22:790-4. doi: 10.1007/BF01709522. PubMed PMID: 8880248.
  24. Buckley TA, Gomersall CD, Ramsay SJ. Validation of the multiple organ dysfunction (MOD) score in critically ill medical and surgical patients. Intensive Care Med. 2003;29:2216-22. doi: 10.1007/s00134-003-2037-z. PubMed PMID: 14566459.
  25. Cook R, Cook D, Tilley J, Lee K, Marshall J, Canadian Critical Care Trials G. Multiple organ dysfunction: baseline and serial component scores. Crit Care Med. 2001;29:2046-50. doi: 10.1097/00003246-200111000-00002. PubMed PMID: 11700393.
  26. Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, et al. Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler Thromb Vasc Biol. 2010;30:1430-8. doi: 10.1161/ATVBAHA.110.207142. PubMed PMID: 20448206; PubMed Central PMCID: PMCPMC2917780.
  27. Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, et al. Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis. Crit Care. 2015;19:88. doi: 10.1186/s13054-015-0832-x. PubMed PMID: 25851781; PubMed Central PMCID: PMCPMC4363356.
  28. Tachyla SA, Marochkov AV, Lipnitski AL, Nikiforova YG. The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction. Korean J Anesthesiol. 2017;70:305-10. doi: 10.4097/kjae.2017.70.3.305. PubMed PMID: 28580081; PubMed Central PMCID: PMCPMC5453892.
  29. Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab. 2004;89:219-26. doi: 10.1210/jc.2003-030760. PubMed PMID: 14715853.
  30. Gruber M, Christ-Crain M, Stolz D, Keller U, Muller C, Bingisser R, et al. Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational study. Swiss Med Wkly. 2009;139:166-72. doi: 10.4414/smw.2009.12494. PubMed PMID: 19330560.
  31. Barati M, Nazari MR, TalebiTaher M, Farhadi N. Comparison of lipid profile in septic and non-septic patients. Archives of Clinical Infectious Diseases. 2011;6:144-7.
  32. Gordon BR, Parker TS, Levine DM, Saal SD, Wang JC, Sloan BJ, et al. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med. 2001;29:1563-8. doi: 10.1097/00003246-200108000-00011. PubMed PMID: 11505128.
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