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Yaghoubi, Atieh, Asli, Samira, Parhizkar, Maryam, Mohammadpour, Maryam, Khorsand, Ali, Yousefi, Mehdi, Bamdad, Taravat, Amel Jamehdar, Saeid. (1401). Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers. سامانه مدیریت نشریات علمی, 20(1), 76-82. doi: 10.22034/iji.2023.93812.2260
Atieh Yaghoubi; Samira Asli; Maryam Parhizkar; Maryam Mohammadpour; Ali Khorsand; Mehdi Yousefi; Taravat Bamdad; Saeid Amel Jamehdar. "Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers". سامانه مدیریت نشریات علمی, 20, 1, 1401, 76-82. doi: 10.22034/iji.2023.93812.2260
Yaghoubi, Atieh, Asli, Samira, Parhizkar, Maryam, Mohammadpour, Maryam, Khorsand, Ali, Yousefi, Mehdi, Bamdad, Taravat, Amel Jamehdar, Saeid. (1401). 'Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers', سامانه مدیریت نشریات علمی, 20(1), pp. 76-82. doi: 10.22034/iji.2023.93812.2260
Yaghoubi, Atieh, Asli, Samira, Parhizkar, Maryam, Mohammadpour, Maryam, Khorsand, Ali, Yousefi, Mehdi, Bamdad, Taravat, Amel Jamehdar, Saeid. Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers. سامانه مدیریت نشریات علمی, 1401; 20(1): 76-82. doi: 10.22034/iji.2023.93812.2260

Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers

Iranian Journal of Immunology
دوره 20، شماره 1، خرداد 2023، صفحه 76-82    اصل مقاله (551.47 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.93812.2260
نویسندگان
Atieh Yaghoubi1، 2؛ Samira Asli3؛ Maryam Parhizkar4؛ Maryam Mohammadpour4؛ Ali Khorsand5؛ Mehdi Yousefi6؛ Taravat Bamdad7؛ Saeid Amel Jamehdar* 2
1Antimicrobial Resistance Research Center, Mashhad University of Medical Science, Mashhad, Iran.
2Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Clinical Research Development Center, Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Hand Hygiene and Infection Control Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
5Department of Complementary and Chines Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
7Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
چکیده
Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is considered a strategy for estimating the effectiveness of the COVID-19 vaccines.
Objective: To examine the antibody levels among the healthcare workers in different hospitals in Mashhad, Iran after receiving the second dose of Sputnik V.
Methods: In this study, we enrolled 230 healthcare workers for evaluating the Gam-COVID-Vac or Sputnik V after the second administration in different hospitals in Mashhad. Antibody levels of spike protein were quantitatively evaluated in a sample of 230 negative RT-PCR tests for the COVID-19 individuals. The analysis has been done based on an immunological assay using enzyme-linked immunosorbent assay (ELISA). The infection history of the subjects and their families was examined through their medical records.
Results: Our results demonstrated a significant association between a higher titer of IgG and a previous history of the COVID-19 infection (P<0.001). Moreover, the chance of detecting antibodies titer more than 50 AU/ml was 16.99 in these people which was significantly higher than in people without a history of infection pre-vaccination [%95CI: (7.38,39.12), P<0.001].
Conclusion: This result demonstrates that the efficacy of antibody production is related to the previous history of the SARS-CoV-2 infections. Ongoing monitoring of the level of antibody among vaccinated populations will help evaluating the effect of vaccines on humoral immunity status.
کلیدواژه‌ها
COVID-19؛ Gam-COVID-Vac؛ SARS-CoV-2؛ Sputnik V
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