|تعداد مشاهده مقاله||10,697,336|
|تعداد دریافت فایل اصل مقاله||5,161,936|
Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers
|Iranian Journal of Immunology|
|دوره 20، شماره 1، خرداد 2023، صفحه 76-82 اصل مقاله (551.47 K)|
|نوع مقاله: Original Article|
|شناسه دیجیتال (DOI): 10.22034/iji.2023.93812.2260|
|Atieh Yaghoubi 1، 2؛ Samira Asli 3؛ Maryam Parhizkar 4؛ Maryam Mohammadpour 4؛ Ali Khorsand 5؛ Mehdi Yousefi 6؛ Taravat Bamdad7؛ Saeid Amel Jamehdar 2|
|1Antimicrobial Resistance Research Center, Mashhad University of Medical Science, Mashhad, Iran.|
|2Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|
|3Clinical Research Development Center, Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|
|4Hand Hygiene and Infection Control Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.|
|5Department of Complementary and Chines Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|
|6Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|
|7Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.|
|Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is considered a strategy for estimating the effectiveness of the COVID-19 vaccines.|
Objective: To examine the antibody levels among the healthcare workers in different hospitals in Mashhad, Iran after receiving the second dose of Sputnik V.
Methods: In this study, we enrolled 230 healthcare workers for evaluating the Gam-COVID-Vac or Sputnik V after the second administration in different hospitals in Mashhad. Antibody levels of spike protein were quantitatively evaluated in a sample of 230 negative RT-PCR tests for the COVID-19 individuals. The analysis has been done based on an immunological assay using enzyme-linked immunosorbent assay (ELISA). The infection history of the subjects and their families was examined through their medical records.
Results: Our results demonstrated a significant association between a higher titer of IgG and a previous history of the COVID-19 infection (P<0.001). Moreover, the chance of detecting antibodies titer more than 50 AU/ml was 16.99 in these people which was significantly higher than in people without a history of infection pre-vaccination [%95CI: (7.38,39.12), P<0.001].
Conclusion: This result demonstrates that the efficacy of antibody production is related to the previous history of the SARS-CoV-2 infections. Ongoing monitoring of the level of antibody among vaccinated populations will help evaluating the effect of vaccines on humoral immunity status.
|COVID-19؛ Gam-COVID-Vac؛ SARS-CoV-2؛ Sputnik V|
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