Igder, Somayeh, Zamani, Mozhdeh, Fakher, Shima, Siri, Morvarid, Ashktorab, Hassan, Brim, Hassan, Łos, Marek J., Mokarram, Pooneh. (1401). Novel Molecular Prognostic and Diagnostic Techniques in Colorectal Cancer. سامانه مدیریت نشریات علمی, 10(4), 130-142. doi: 10.30476/acrr.2023.97941.1168
Somayeh Igder; Mozhdeh Zamani; Shima Fakher; Morvarid Siri; Hassan Ashktorab; Hassan Brim; Marek J. Łos; Pooneh Mokarram. "Novel Molecular Prognostic and Diagnostic Techniques in Colorectal Cancer". سامانه مدیریت نشریات علمی, 10, 4, 1401, 130-142. doi: 10.30476/acrr.2023.97941.1168
Igder, Somayeh, Zamani, Mozhdeh, Fakher, Shima, Siri, Morvarid, Ashktorab, Hassan, Brim, Hassan, Łos, Marek J., Mokarram, Pooneh. (1401). 'Novel Molecular Prognostic and Diagnostic Techniques in Colorectal Cancer', سامانه مدیریت نشریات علمی, 10(4), pp. 130-142. doi: 10.30476/acrr.2023.97941.1168
Igder, Somayeh, Zamani, Mozhdeh, Fakher, Shima, Siri, Morvarid, Ashktorab, Hassan, Brim, Hassan, Łos, Marek J., Mokarram, Pooneh. Novel Molecular Prognostic and Diagnostic Techniques in Colorectal Cancer. سامانه مدیریت نشریات علمی, 1401; 10(4): 130-142. doi: 10.30476/acrr.2023.97941.1168

Novel Molecular Prognostic and Diagnostic Techniques in Colorectal Cancer

Iranian Journal of Colorectal Research
مقاله 2، دوره 10، شماره 4، زمستان 2022، صفحه 130-142    اصل مقاله (1.06 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/acrr.2023.97941.1168
نویسندگان
Somayeh Igder1؛ Mozhdeh Zamani2، 3؛ Shima Fakher3؛ Morvarid Siri2؛ Hassan Ashktorab4؛ Hassan Brim5؛ Marek J. Łos2، 6؛ Pooneh Mokarram* 7
1Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Medicine, Gastroenterology Division, and Cancer Center, Howard University College of Medicine, Washington DC, USA
5Department of Pathology, Gastroenterology Division, and Cancer Center, Howard University College of Medicine, Washington DC, USA
6Department of Pathology, Unii Lubelskiej 1, Pomeranian Medical University, 71-344 Szczecin, Poland
7Autophagy Research Center, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Colorectal cancer (CRC) is a prominent cause of malignancy-associated death worldwide. This disease is predominantly symptomless as it advances to the highest stages, meaning that screening schemes aimed at early diagnosis are required to lower the prevalence and fatality rate. We aimed to review the literature on different molecular procedures for detecting stool-based biomarkers of CRC. 
We reviewed papers from Google Scholar and PubMed on different molecular procedures for detecting stool-based biomarkers of CRC with no time limitation. 
An integrative framework of all epigenetic and genetic modifications was studied, representing more acceptable specificity and sensitivity for the diagnosis, treatment, and drug response/outcome evaluation of CRC compared to other traditional procedures. Differential expression analysis of stool-derived RNA (sRNA) and stool DNA (sDNA) testing for ultrasensitive mutations, methylation, and fragmentation patterns can lead to an accurate, early-stage diagnosis and a better prognosis for CRC patients.
کلیدواژه‌ها
Colorectal cancer؛ DNA؛ Feces؛ Screening؛ Diagnosis؛ Prognosis
مراجع
آمار
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