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Habib, Arslan, Anjum, Khalid, Iqbal, Riffat, Jaffar, Ghulam, Ashraf, Zeeshan, Khalid, Malik, Taj, Muhammad, Zainab, Syeda, Umair, Muhammad, Zohaib, Muhammad, Khalid, Tabinda. (1401). Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions. سامانه مدیریت نشریات علمی, 20(1), 1-15. doi: 10.22034/iji.2023.94097.2284
Arslan Habib; Khalid Mahmood Anjum; Riffat Iqbal; Ghulam Jaffar; Zeeshan Ashraf; Malik ShahZaib Khalid; Muhammad Usman Taj; Syeda Wafa Zainab; Muhammad Umair; Muhammad Zohaib; Tabinda Khalid. "Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions". سامانه مدیریت نشریات علمی, 20, 1, 1401, 1-15. doi: 10.22034/iji.2023.94097.2284
Habib, Arslan, Anjum, Khalid, Iqbal, Riffat, Jaffar, Ghulam, Ashraf, Zeeshan, Khalid, Malik, Taj, Muhammad, Zainab, Syeda, Umair, Muhammad, Zohaib, Muhammad, Khalid, Tabinda. (1401). 'Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions', سامانه مدیریت نشریات علمی, 20(1), pp. 1-15. doi: 10.22034/iji.2023.94097.2284
Habib, Arslan, Anjum, Khalid, Iqbal, Riffat, Jaffar, Ghulam, Ashraf, Zeeshan, Khalid, Malik, Taj, Muhammad, Zainab, Syeda, Umair, Muhammad, Zohaib, Muhammad, Khalid, Tabinda. Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions. سامانه مدیریت نشریات علمی, 1401; 20(1): 1-15. doi: 10.22034/iji.2023.94097.2284

Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions

Iranian Journal of Immunology
دوره 20، شماره 1، خرداد 2023، صفحه 1-15    اصل مقاله (735.8 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.94097.2284
نویسندگان
Arslan Habib* 1؛ Khalid Mahmood Anjum2؛ Riffat Iqbal3؛ Ghulam Jaffar2؛ Zeeshan Ashraf4؛ Malik ShahZaib Khalid5؛ Muhammad Usman Taj4؛ Syeda Wafa Zainab6؛ Muhammad Umair7؛ Muhammad Zohaib8؛ Tabinda Khalid9
1Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China.
2Department of Wildlife and Ecology, University of Veterinary and Animals Sciences, Lahore, Pakistan.
3Department of Zoology, Government College University, Lahore, Pakistan.
4Department of Fisheries and Aquaculture, University of Veterinary and Animals Sciences, Lahore, Pakistan.
5Institute of Zoology, University of the Punjab, Lahore, Pakistan.
6Institute of Chemistry, Faculty of Sciences, University of Sargodha, Pakistan.
7Department of Zoology, University of Okara, Pakistan.
8Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
9Department of Zoology, Lahore College for Women University, Lahore, Pakistan.
چکیده
The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and provide protection against different kinds of infections. Subunit vaccines are safe and less toxic, but due to their lower immunogenicity, they need adjuvants to boost the immune system. Adjuvants are small particles/molecules integrated into a vaccine to enhance the immunogenic feedback of antigens. They play a significant role to enhance the potency and efficiency of vaccines. There are several types of adjuvants with different mechanisms of action; therefore, improved knowledge of their immunogenicity will help develop a new generation of adjuvants. Many trials have been designed using different kinds of vaccine adjuvants to examine their safety and efficacy, but in practice, only a few have entered in animal and human clinical trials. However, for the development of safe and effective vaccines, it is important to have adequate knowledge of the side effects and toxicity of different adjuvants. The current review discussed the adjuvants which are available for producing modern vaccines as well as some new classes of adjuvants in clinical trials.
کلیدواژه‌ها
Adjuvants؛ Immune system؛ Immunogenic feedback؛ Licensed adjuvants؛ Vaccine
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