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Daei, Sajedeh, Ziamajidi, Nasrin, Abbasalipourkabir, Roghayeh, Aminzadeh, Zeynab, Vahabirad, Mohammad. (1402). Evaluating Oxidative Stress Condition in Human Bladder Cancer 5637 Cell Line upon Exposure to Silver Nanoparticles. سامانه مدیریت نشریات علمی, 14(3), 370-377. doi: 10.30476/mejc.2023.95249.1759
Sajedeh Daei; Nasrin Ziamajidi; Roghayeh Abbasalipourkabir; Zeynab Aminzadeh; Mohammad Vahabirad. "Evaluating Oxidative Stress Condition in Human Bladder Cancer 5637 Cell Line upon Exposure to Silver Nanoparticles". سامانه مدیریت نشریات علمی, 14, 3, 1402, 370-377. doi: 10.30476/mejc.2023.95249.1759
Daei, Sajedeh, Ziamajidi, Nasrin, Abbasalipourkabir, Roghayeh, Aminzadeh, Zeynab, Vahabirad, Mohammad. (1402). 'Evaluating Oxidative Stress Condition in Human Bladder Cancer 5637 Cell Line upon Exposure to Silver Nanoparticles', سامانه مدیریت نشریات علمی, 14(3), pp. 370-377. doi: 10.30476/mejc.2023.95249.1759
Daei, Sajedeh, Ziamajidi, Nasrin, Abbasalipourkabir, Roghayeh, Aminzadeh, Zeynab, Vahabirad, Mohammad. Evaluating Oxidative Stress Condition in Human Bladder Cancer 5637 Cell Line upon Exposure to Silver Nanoparticles. سامانه مدیریت نشریات علمی, 1402; 14(3): 370-377. doi: 10.30476/mejc.2023.95249.1759

Evaluating Oxidative Stress Condition in Human Bladder Cancer 5637 Cell Line upon Exposure to Silver Nanoparticles

Middle East Journal of Cancer
مقاله 3، دوره 14، شماره 3 - شماره پیاپی 55، مهر 2023، صفحه 370-377    اصل مقاله (2.37 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.95249.1759
نویسندگان
Sajedeh Daei1؛ Nasrin Ziamajidi* 1، 2؛ Roghayeh Abbasalipourkabir1؛ Zeynab Aminzadeh1؛ Mohammad Vahabirad1
1Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Background: Bladder cancer (BC) is known as the most frequent neoplasm of the urinary system, whose prevalence has significantly increased over the past three decades. Successful treatment of BC is a highly challenging task. In this regard, several studies have demonstrated that increased level of oxidative stress may cause cancer cells death. Furthermore, silver nanoparticles (AgNPs) are recognized as one of the most widely used nanomaterials in cancer treatment. Herein, we evaluated the AgNPs-induced oxidative stress in BC 5637 cell line.
Method: In the current experimental study, using colorimetric reactions, we assessed the levels of oxidative stress parameters, including malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) as antioxidant enzymes. Moreover, we performed the statistical analysis via One-way ANOVA and post-hoc Tukey tests to draw comparisons between the groups.
Results: The results indicated an increased amount of TOS, MDA, and oxidative stress index. Nonetheless, there was a remarkable reduction in SOD, GPx, and CAT activities and TAC level in the AgNPs-exposed cells compared to the control untreated ones (P < 0.05).
Conclusion: All in all, AgNPs have the potential to induce oxidative stress in 5637 cells. We thus concluded that AgNPs can be chosen as an antitumor agent for future investigations to treat BC.

تازه های تحقیق

Sajedeh Daei (Google Scholar)

Nasrin Ziamajidi (Google Scholar)
کلیدواژه‌ها
Metal nanoparticles؛ Silver؛ Oxidative stress؛ Urinary bladder؛ Cell line
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