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Kiaipour, Zahra, Shafiee, Mahdieh, Ansari, Ghasseem. (1403). Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials. سامانه مدیریت نشریات علمی, 25(2), 97-107. doi: 10.30476/dentjods.2023.96000.1912
Zahra Kiaipour; Mahdieh Shafiee; Ghasseem Ansari. "Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials". سامانه مدیریت نشریات علمی, 25, 2, 1403, 97-107. doi: 10.30476/dentjods.2023.96000.1912
Kiaipour, Zahra, Shafiee, Mahdieh, Ansari, Ghasseem. (1403). 'Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials', سامانه مدیریت نشریات علمی, 25(2), pp. 97-107. doi: 10.30476/dentjods.2023.96000.1912
Kiaipour, Zahra, Shafiee, Mahdieh, Ansari, Ghasseem. Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials. سامانه مدیریت نشریات علمی, 1403; 25(2): 97-107. doi: 10.30476/dentjods.2023.96000.1912

Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials

Journal of Dentistry
مقاله 2، دوره 25، شماره 2 - شماره پیاپی 83، شهریور 2024، صفحه 97-107    اصل مقاله (633.47 K)
نوع مقاله: Systematic Review
شناسه دیجیتال (DOI): 10.30476/dentjods.2023.96000.1912
نویسندگان
Zahra Kiaipour1؛ Mahdieh Shafiee2؛ Ghasseem Ansari* 3
1Postgraduate Student, Dept. of Pediatric Dentistry, Dental School of Shahid Beheshti University of Medical Sciences, Tehran Iran.
2Stem Cell Research Canter, Tissue Engineering and Regenerative Medicine Institute, Tehran Central Branch, Islamic Azad University, Tehran, Iran.
3Head of the Hospital Dentistry and Sedation Unit, Dept. of Pediatric Dentistry, Past-President of IADR-Iranian Division, Dental School Shahid Beheshti Medical University, Tehran, Iran.
چکیده
Statement of the Problem: Treatment of immature necrotic teeth is a problematic situation. Conventional root canal therapy is challenging and leaves a weak, fragile and undeveloped tooth for lifetime.
Purpose: This review was aimed to assess the outcome of available randomized clinical tr-ials (RCTs) on the efficacy of platelet concentrates (PC) in dentine-pulp complex regeneration.
Materials and Method: An electronic search was conducted on MEDLINE, EMBASE, Cochrane, and Google scholar databases. A further manual search was performed on the list of related articles in order to ensure inclusion of potentially missed articles in earlier electronic search. Those proved RCTs matched with the standard criteria were included following an initial assessment of abstracts and the text independently by the reviewers.
Results: From the total 602 harvested articles, only 13 met the criteria and were evaluated with 11 having parallel design and 2 split mouth. Only one study featured low risk of bias, while three had moderate risk and the rest were at high risk of bias. Six studies had used platelet rich plasma (PRP), 4 employed platelet rich fibrin (PRF), one utilized injectable platelet rich fibrin (I-PRF), and three used both PRF and PRP for their experimental groups while blood clot (BC) was used as the control group for all. The success rate was reported at 87.3% judged by the absence of pathologic signs and symptoms.
Conclusion: Dentin wall thickening, root lengthening and apex closure were higher in PC groups, however, these differences were not statistically significant in reported studies. It can be concluded that PCs promote the pulp tissue revitalization and continuation of root development. However, a consensus on its potency for true pulp regeneration is yet to be reached.
کلیدواژه‌ها
Dental Pulp؛ Regeneration؛ Platelet Concentrates؛ Platelet rich plasma؛ Platelet rich fibrin؛ Injectable Platelet rich fibrin
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