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Fattahi-Saravi, Zeinabsadat, Naderi-Boldaji, Vida, Azizollahi, Azadeh, Azemati, Simin, Asmarian, Naeimehossadat, Khosravi, Mohammad-Bagher. (1402). Adequate Anesthesia and More Effective Analgesia by Adjusted Doses of Bupivacaine during Cesarean Section: A Randomized Double-blind Clinical Trial. سامانه مدیریت نشریات علمی, 48(4), 393-400. doi: 10.30476/ijms.2022.95205.2653
Zeinabsadat Fattahi-Saravi; Vida Naderi-Boldaji; Azadeh Azizollahi; Simin Azemati; Naeimehossadat Asmarian; Mohammad-Bagher Khosravi. "Adequate Anesthesia and More Effective Analgesia by Adjusted Doses of Bupivacaine during Cesarean Section: A Randomized Double-blind Clinical Trial". سامانه مدیریت نشریات علمی, 48, 4, 1402, 393-400. doi: 10.30476/ijms.2022.95205.2653
Fattahi-Saravi, Zeinabsadat, Naderi-Boldaji, Vida, Azizollahi, Azadeh, Azemati, Simin, Asmarian, Naeimehossadat, Khosravi, Mohammad-Bagher. (1402). 'Adequate Anesthesia and More Effective Analgesia by Adjusted Doses of Bupivacaine during Cesarean Section: A Randomized Double-blind Clinical Trial', سامانه مدیریت نشریات علمی, 48(4), pp. 393-400. doi: 10.30476/ijms.2022.95205.2653
Fattahi-Saravi, Zeinabsadat, Naderi-Boldaji, Vida, Azizollahi, Azadeh, Azemati, Simin, Asmarian, Naeimehossadat, Khosravi, Mohammad-Bagher. Adequate Anesthesia and More Effective Analgesia by Adjusted Doses of Bupivacaine during Cesarean Section: A Randomized Double-blind Clinical Trial. سامانه مدیریت نشریات علمی, 1402; 48(4): 393-400. doi: 10.30476/ijms.2022.95205.2653

Adequate Anesthesia and More Effective Analgesia by Adjusted Doses of Bupivacaine during Cesarean Section: A Randomized Double-blind Clinical Trial

Iranian Journal of Medical Sciences
مقاله 6، دوره 48، شماره 4، مهر 2023، صفحه 393-400    اصل مقاله (272.1 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.95205.2653
نویسندگان
Zeinabsadat Fattahi-Saravi1؛ Vida Naderi-Boldaji2؛ Azadeh Azizollahi1؛ Simin Azemati1؛ Naeimehossadat Asmarian1؛ Mohammad-Bagher Khosravi* 1
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Several adjuvants, added to local anesthetics, were suggested to induce an ideal regional block with high-quality analgesia. The purpose of this study was to evaluate the particular blocking properties of low-dose bupivacaine in combination with meperidine and fentanyl in spinal anesthesia during Cesarean sections.
Methods: A randomized, double-blind clinical trial was conducted at Hafez Hospital affiliated with Shiraz University of Medical Sciences (Shiraz, Iran) from February 2015 to February 2016. A total of 120 pregnant women, who underwent spinal anesthesia during elective Cesarean section were enrolled in the study. Based on block-wise randomization, the patients were randomly assigned to three groups, namely “B” group received 2 mL bupivacaine 0.5% (10 mg), “BM” group received 8 mg bupivacaine and 10 mg meperidine, and “BF” group received 8 mg bupivacaine and 15 µg fentanyl intrathecally. The block onset, the duration of analgesia, and the time of discharge from the post-anesthesia care unit (PACU) were all assessed. Data were analyzed using SPSS software version 21, and P<0.05 were considered statistically significant.
Results: The mean duration of motor blocks in the B group (150 min) were significantly higher than the BM 
(102 min) and BF (105 min) groups (P<0.0001). In both the BM and BF groups, the duration of sensory and motor blocks was the same. The length of stay in the PACU was significantly longer in the B group (P<0.001) than the BM and BF groups. When meperidine or fentanyl was added to bupivacaine, the duration of the analgesia lengthened (P<0.001). 
Conclusion: Intrathecal low-dose spinal anesthesia induced by bupivacaine (8 mg) in combination with meperidine and/or fentanyl for Cesarean section increased maternal hemodynamic stability, while ensuring effective anesthetic conditions, extending effective analgesia, and reducing the length of stay in PACU.
Trial Registration Number: IRCT2015013119470N14.
کلیدواژه‌ها
Bupivacaine؛ Anesthesia, spinal؛ Local anesthesia؛ Meperidine؛ Fentanyl؛ Cesarean section
سایر فایل های مرتبط با مقاله
مراجع
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