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Mohammadi, Khadije, Shojaeifard, Maryam, Mirtajaddini, Marzieh, Hekmat, Hamidreza, Davoudi, Zahra, Erfanifar, Azam. (1401). Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2022.92556.2389
Khadije Mohammadi; Maryam Shojaeifard; Marzieh Mirtajaddini; Hamidreza Hekmat; Zahra Davoudi; Azam Erfanifar. "Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.30476/ijms.2022.92556.2389
Mohammadi, Khadije, Shojaeifard, Maryam, Mirtajaddini, Marzieh, Hekmat, Hamidreza, Davoudi, Zahra, Erfanifar, Azam. (1401). 'Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2022.92556.2389
Mohammadi, Khadije, Shojaeifard, Maryam, Mirtajaddini, Marzieh, Hekmat, Hamidreza, Davoudi, Zahra, Erfanifar, Azam. Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.30476/ijms.2022.92556.2389

Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 19 دی 1401  XML اصل مقاله (573.04 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.92556.2389
نویسندگان
Khadije Mohammadi email orcid 1؛ Maryam Shojaeifard2؛ Marzieh Mirtajaddiniorcid 3؛ Hamidreza Hekmat4؛ Zahra Davoudi5؛ Azam Erfanifar5
1Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran
2Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
3Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
4School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran
5Department of Endocrinology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Since hyperthyroidism could be associated with right ventricular dysfunction, this study intended to investigate right ventricular (RV) function using strain echocardiography in hyperthyroid patients both at rest and in maximum-stress conditions. 
Methods: This cross-sectional study was conducted at Rajaie Cardiovascular Medical and Research Center, Tehran, Iran, from January 2019 to January 2020. All study participants completed a maximum treadmill exercise test, as well as a complete two-dimensional echocardiogram at rest and the peak of stress test. The data were analyzed using SPSS statistical software. The independent samples t test and Mann–Whitney U test were used for numerical, and the Chi square test was used for nominal variables. P<0.05 was considered statistically significant. 
Results: The final analysis included 52 participants (26 subjects in each group). In a maximal stress situation, we found that among the RV function indices, RV global longitudinal strain (P=0.0001), systolic strain rate (P=0.0001), diastolic strain rate (P=0.0002), and tricuspid annular plane systolic excursion (P=0.019) were reduced significantly in the hyperthyroid patients compared to the control group. There was also a linear correlation between RV size and thyroid stimulating hormone (TSH) level (P=0.009, r=0.36). Moreover, we found a negative linear correlation between TSH level with maximum stress RV strain and diastolic strain rate (P<0.001).
Conclusion: The findings of the present study revealed a significant change in RV function indices among hyperthyroid patients. Therefore, it highlights the necessity of early diagnosis and treatment of hyperthyroidism, as well as RV function evaluation in these patients.
کلیدواژه‌ها
Ventricular function, right؛ Hyperthyroidism؛ Exercise test؛ Echocardiography
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