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Forghani, Nima, Karimi, Zeinab, Mokhtari, Mokhtar, Shariati, Mehrdad, Masjedi, Fatemeh. (1401). Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model. سامانه مدیریت نشریات علمی, 48(2), 187-197. doi: 10.30476/ijms.2022.93594.2497
Nima Forghani; Zeinab Karimi; Mokhtar Mokhtari; Mehrdad Shariati; Fatemeh Masjedi. "Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model". سامانه مدیریت نشریات علمی, 48, 2, 1401, 187-197. doi: 10.30476/ijms.2022.93594.2497
Forghani, Nima, Karimi, Zeinab, Mokhtari, Mokhtar, Shariati, Mehrdad, Masjedi, Fatemeh. (1401). 'Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model', سامانه مدیریت نشریات علمی, 48(2), pp. 187-197. doi: 10.30476/ijms.2022.93594.2497
Forghani, Nima, Karimi, Zeinab, Mokhtari, Mokhtar, Shariati, Mehrdad, Masjedi, Fatemeh. Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model. سامانه مدیریت نشریات علمی, 1401; 48(2): 187-197. doi: 10.30476/ijms.2022.93594.2497

Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model

Iranian Journal of Medical Sciences
مقاله 10، دوره 48، شماره 2، خرداد 2023، صفحه 187-197    اصل مقاله (561 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.93594.2497
نویسندگان
Nima Forghani1؛ Zeinab Karimi* 2؛ Mokhtar Mokhtari1؛ Mehrdad Shariati1؛ Fatemeh Masjedi2
1Department of Biology, School of Sciences, Islamic Azad University, Kazerun Branch, Kazerun, Iran
2Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Polycystic ovary syndrome (PCOS) is the most common reproductive dysfunction in premenopausal women. PCOS is associated with oxidative stress (OS), which is the main risk factor for renal diseases. This study aimed to investigate the mechanisms responsible for renal injury in a hyperandrogenemic female rat model. 
Methods: This study was conducted from December 2019 to September 2021 at Shiraz Nephro-Urology Research Centre, Shiraz University of Medical Sciences (Shiraz, Iran). Thirty female Sprague-Dawley rats were randomly divided into three groups (n=10), namely control, sham, and 
dehydroepiandrosterone (DHEA). Plasma total testosterone, plasma creatinine (Cr), and blood urea nitrogen (BUN) levels were measured. In addition, total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and histopathological changes in the ovaries and kidneys were determined. Data were analyzed using the GraphPad Prism software, and P<0.05 was considered statistically significant.
Results: Plasma total testosterone levels increased by nine-fold in DHEA-treated rats compared to controls (P=0.0001). Administration of DHEA increased Cr and BUN levels and caused severe renal tubular cell injury. In addition, plasma and tissue (kidney and ovary) TAC levels decreased significantly, but TOS levels and OSI values were significantly increased (P=0.019). Significant damage to both glomerular and tubular parts of the kidney and ovarian follicular structure was observed in the DHEA group.
Conclusion: Hyperandrogenemia caused systemic abnormalities through OS-related mechanisms and damaged renal and ovarian tissues. DHEA treatment in rat models is recommended to study the mechanisms that mediate PCOS-associated renal injury.
کلیدواژه‌ها
Polycystic ovary syndrome؛ Oxidative stress؛ Dehydroepiandrosterone؛ Kidney disease
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