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Pourmand, Daryoush, Veisi-Raygani, Asad, Bahrehmand, Fariborz, Asadi, Soheila. (1402). The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease. سامانه مدیریت نشریات علمی, 48(4), 414-419. doi: 10.30476/ijms.2022.94850.2616
Daryoush Pourmand; Asad Veisi-Raygani; Fariborz Bahrehmand; Soheila Asadi. "The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease". سامانه مدیریت نشریات علمی, 48, 4, 1402, 414-419. doi: 10.30476/ijms.2022.94850.2616
Pourmand, Daryoush, Veisi-Raygani, Asad, Bahrehmand, Fariborz, Asadi, Soheila. (1402). 'The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease', سامانه مدیریت نشریات علمی, 48(4), pp. 414-419. doi: 10.30476/ijms.2022.94850.2616
Pourmand, Daryoush, Veisi-Raygani, Asad, Bahrehmand, Fariborz, Asadi, Soheila. The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease. سامانه مدیریت نشریات علمی, 1402; 48(4): 414-419. doi: 10.30476/ijms.2022.94850.2616

The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease

Iranian Journal of Medical Sciences
مقاله 8، دوره 48، شماره 4، مهر 2023، صفحه 414-419    اصل مقاله (317.48 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.94850.2616
نویسندگان
Daryoush Pourmand1؛ Asad Veisi-Raygani2؛ Fariborz Bahrehmand3؛ Soheila Asadi* 1
1Department of Laboratory Sciences, School of Para Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: The Apolipoprotein E (ApoE) polymorphism plays an important role in the pathophysiology of end-stage renal disease (ESRD). Additionally, ApoE may contribute to the progression of oxidative stress. Thus, this study aimed to determine the ApoE gene polymorphism and evaluate the malondialdehyde (MDA) level in ESRD patients and healthy individuals.
Methods: The present cross-sectional study was conducted at 2010 at Kermanshah University of Medical Sciences (Kermanshah, Iran). The study population comprised ESRD patients (n=136) and healthy individuals (n=137). The MDA level was assessed using high-performance liquid chromatography (HPLC), and the frequencies of ApoE gene alleles were analyzed using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). The data were analyzed using Statistical Package for Social Sciences (SPSS), version 13. The significant differences of ApoE genotypes in case and control groups were assessed using Pearson’s Chi square tests, and two-tailed Student’s tests. A logistic regression model was used to calculate the odd ratio. P<0.05 was considered statistically significant. 
Results: According to the results, ESRD patients had a higher frequency of the E2/E3 genotype than the healthy group (P<0.001). The results indicated that E3/E4 genotype frequency in the patients’ group was higher than that of the control group (P=0.026). Furthermore, the  E3/E2 (OR=5.7, 95% CI=2.68-12.14) (P<0.001) and E3/E4 (OR=1.57, 95% CI=1.05-2.34) (P=0.029) genotypes were found to increase the risk of ESRD. Moreover, the MDA level in ESRD patients was higher than the healthy individuals (P<0.001). The patients with E3/E2 (P<0.001) and E3/E4 (P<0.001) genotypes had a higher level of MDA than the control group. 
Conclusion: According to the findings, patients with ESRD had higher genotypes of E3/E2 and E3/E4, which suggests a higher risk of developing ESRD. 
کلیدواژه‌ها
Kidney Failure, Chronic؛ Apolipoproteins E؛ Malondialdehyde؛ Polymorphism
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