Association between Non-alcoholic Fatty Liver Disease and Breast Cancer: A Systematic Review and Meta-analysis Study | ||
| Middle East Journal of Cancer | ||
| مقاله 1، دوره 14، شماره 4 - شماره پیاپی 56، 2023، صفحه 471-480 اصل مقاله (2.19 M) | ||
| نوع مقاله: Review Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2023.95903.1795 | ||
| نویسندگان | ||
| Alireza Hejrati1؛ Vahid Rahmanian2؛ Hamideh Hasannejad3؛ Lina Hejrati4؛ Bahareh Shateri Amiri* 1 | ||
| 1Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Public Health, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran | ||
| 3Department of Food Hygiene and Quality Control, Division of Epidemiology and Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: Breast cancer (BC) is the most prevalent neoplasm in females globally, with an increasing incidence trend almost in all regions. Previous studies have indicated that non-alcoholic fatty liver disease (NAFLD) may be an emerging risk factor for extrahepatic cancers, including BC. This systematic review and meta-analysis study aimed to determine the association between NAFLD and the development of BC. Method: Data were systematically collected without time limitation until 21 April 2022, from the following electronic databases: PubMed, Scopus, Embase, Web of Science, and Google Scholar. The association between NAFLD and BC with odds ratio (OR) was calculated with a 95% confidence interval (CI) and presented via forest plots. Hazard ratios along with incidence rate ratios in the cohort studies transformed into OR. Results: According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and the inclusion criteria herein, 11 eligible studies were obtained from various countries. The pooled OR of NAFLD as a risk of developing BC, using a random-effects model, was estimated at 1.61 (95% CI: 1.30-2.00) (Q-value: 51.35, I2 = 80.52%, P < 0.0001). Multivariate meta-regression analysis showed that the publication year-, country-, detection method-, study design-, and body mass index-adjusted status did not cause heterogeneity. The Egger's regression (P = 0.32) and the symmetry in the funnel plot showed no publication bias in the studies. Conclusion: The present research revealed that NAFLD had a significant association with BC, independent of traditional risk factors. | ||
تازه های تحقیق | ||
Alireza Hejrati (Google Scholar) Bahareh Shateri Amiri (Google Scholar) | ||
| کلیدواژهها | ||
| Breast cancer؛ Non-alcoholic fatty liver disease؛ Systematic review؛ Association | ||
| مراجع | ||
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