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Bahadori, Mahshid, Nguyen, Nam-Phong, Bahrami, Faranak, Tadayon, Seyed Mohammad Kazem, Mohammadianpanah, Mohammad. (1401). Watch-and-wait Therapeutic Approach in Locally Advanced Rectal Cancer: An Innovative or Inevitable Option for Rectal Preservation. سامانه مدیریت نشریات علمی, 10(4), 123-129. doi: 10.30476/acrr.2023.97583.1165
Mahshid Bahadori; Nam-Phong Nguyen; Faranak Bahrami; Seyed Mohammad Kazem Tadayon; Mohammad Mohammadianpanah. "Watch-and-wait Therapeutic Approach in Locally Advanced Rectal Cancer: An Innovative or Inevitable Option for Rectal Preservation". سامانه مدیریت نشریات علمی, 10, 4, 1401, 123-129. doi: 10.30476/acrr.2023.97583.1165
Bahadori, Mahshid, Nguyen, Nam-Phong, Bahrami, Faranak, Tadayon, Seyed Mohammad Kazem, Mohammadianpanah, Mohammad. (1401). 'Watch-and-wait Therapeutic Approach in Locally Advanced Rectal Cancer: An Innovative or Inevitable Option for Rectal Preservation', سامانه مدیریت نشریات علمی, 10(4), pp. 123-129. doi: 10.30476/acrr.2023.97583.1165
Bahadori, Mahshid, Nguyen, Nam-Phong, Bahrami, Faranak, Tadayon, Seyed Mohammad Kazem, Mohammadianpanah, Mohammad. Watch-and-wait Therapeutic Approach in Locally Advanced Rectal Cancer: An Innovative or Inevitable Option for Rectal Preservation. سامانه مدیریت نشریات علمی, 1401; 10(4): 123-129. doi: 10.30476/acrr.2023.97583.1165

Watch-and-wait Therapeutic Approach in Locally Advanced Rectal Cancer: An Innovative or Inevitable Option for Rectal Preservation

Iranian Journal of Colorectal Research
مقاله 1، دوره 10، شماره 4، اسفند 2022، صفحه 123-129    اصل مقاله (599.73 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/acrr.2023.97583.1165
نویسندگان
Mahshid Bahadori1؛ Nam-Phong Nguyen2؛ Faranak Bahrami3؛ Seyed Mohammad Kazem Tadayon3؛ Mohammad Mohammadianpanah* 3
1School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, NW Suite BA-07, Washington, DC 20060, USA
3Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Neoadjuvant chemoradiation followed by total mesorectal excision through a low anterior resection (LAR) or abdominoperineal resection (APR) is considered the standard treatment approach in most patients with locally advanced rectal cancer. While LAR allows for anatomic rectal preservation, APR leads to significant morbidity and compromised quality of life in rectal cancer patients. Approximately 10-40% of patients achieve clinical complete response (cCR) following neoadjuvant chemoradiation. Meanwhile, the pathologic complete response (pCR) rate is usually less than the cCR rate. The complete response rate may be improved by escalating the radiation dose and optimizing (total) neoadjuvant chemotherapy. Therefore, at least one-fifth of patients will have the chance of rectal preservation using the watch-and-wait strategy. In this therapeutic strategy, patients should be followed up by an active surveillance protocol to detect early tumor regrowth and undergo salvage radical surgery and will, therefore, provide comparable oncologic outcomes to those achieved in patients who undergo initial radical surgery. This study aimed to review the most recent evidence and guidelines regarding the watch-and-wait therapeutic strategy in patients with rectal cancer.
کلیدواژه‌ها
Watchful waiting؛ Rectal cancer؛ Neoadjuvant therapy
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