|تعداد مشاهده مقاله||10,670,171|
|تعداد دریافت فایل اصل مقاله||5,133,031|
The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis
|Iranian Journal of Immunology|
|دوره 19، شماره 4، اسفند 2022، صفحه 427-435 اصل مقاله (540.82 K)|
|نوع مقاله: Original Article|
|شناسه دیجیتال (DOI): 10.22034/iji.2022.90456.2007|
|Mehrdad Shavandi 1، 2؛ Yasaman Yazdani 3؛ Shirin Asar 4؛ Arash Mohammadi 5؛ Ehsan Mohammadi-noori 6؛ Amir Kiani 7|
|1Students’ Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran|
|2Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran|
|3Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada|
|4Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran|
|5School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran|
|6Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran|
|7Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran|
| Background: Rheumatoid Arthritis (RA) is a systemic chronic autoimmune disease. Several inflammatory agents play key roles in RA pathogenesis, among which tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) are of great importance. Silymarin is a potent anti-oxidant extracted from Silybummarianum L. seeds.|
Objective: To study the effect of silymarin on serum levels of TNF-α and IL-1β in patients with RA.
Methods: Patients with stable RA received 140 mg of silymarin, 3 times a day, for 3 months. Serum samples were collected before and after the treatment. Both TNF-α and IL-1β serum levels were measured by ELISA.
Results: 42 patients (14.3% male, and 85.7% female, with a mean age of 47.59±12.8 years old) completed the treatment course. There was no significant difference in the overall mean concentration of either TNF-α (p=0.14) or IL-1β (p=0.27) in all 42 patients after the treatment with silymarin.
Conclusion: The addition of silymarin to the treatment regimen of patients with stable RA has no significant effect on the serum levels of TNF-α and IL-1β, however, this study needs further evaluation with a larger sample size.
|IL-1β؛ Rheumatoid Arthritis؛ Silymarin؛ TNF-α|
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