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Darai, Masumeh, Soleimanian, Saeede, Yaghobi, Ramin, Kazemi, Kourosh, Nikeghbalian, Saman, Azarpira, Negar. (1401). The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients. سامانه مدیریت نشریات علمی, 19(4), 404-413. doi: 10.22034/iji.2022.95345.2359
Masumeh Darai; Saeede Soleimanian; Ramin Yaghobi; Kourosh Kazemi; Saman Nikeghbalian; Negar Azarpira. "The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients". سامانه مدیریت نشریات علمی, 19, 4, 1401, 404-413. doi: 10.22034/iji.2022.95345.2359
Darai, Masumeh, Soleimanian, Saeede, Yaghobi, Ramin, Kazemi, Kourosh, Nikeghbalian, Saman, Azarpira, Negar. (1401). 'The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients', سامانه مدیریت نشریات علمی, 19(4), pp. 404-413. doi: 10.22034/iji.2022.95345.2359
Darai, Masumeh, Soleimanian, Saeede, Yaghobi, Ramin, Kazemi, Kourosh, Nikeghbalian, Saman, Azarpira, Negar. The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients. سامانه مدیریت نشریات علمی, 1401; 19(4): 404-413. doi: 10.22034/iji.2022.95345.2359

The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients

Iranian Journal of Immunology
دوره 19، شماره 4، اسفند 2022، صفحه 404-413    اصل مقاله (660.64 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2022.95345.2359
نویسندگان
Masumeh Darai1؛ Saeede Soleimanian2؛ Ramin Yaghobi1؛ Kourosh Kazemi3؛ Saman Nikeghbalian3؛ Negar Azarpira* 1
1Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important roles in immunity to viruses. The 14bp insertion/deletion polymorphism impacts HLA-G mRNA stability. Regarding the HLA-E molecule, two nonsynonymous alleles, HLA-E*0101, and HLA-E*0103 are different in their functions including the affinity of the relative peptide.
Objective: To explore the possible link between HLA-G and HLA-E polymorphisms with CMV reinfection among liver transplant recipients (LTRs).
Methods: In this study, a total of 140 liver transplantations were performed; of which 70 CMV-reactivated LTRs and 70 CMV non-reactivated ones were recruited. The cut-off value of CMV DNA was determined to be 100 copies/mL. PCR evaluated different genotypes for HLA-G and ARMS-PCR for HLA-E*0101 and *0103.
Results: Neither the HLA-G genotypes (-14 bp/-14bp and +14bp/+14 bp homozygous genotypes with the p-values: 0.43, and 0.13, respectively +14 bp⁄-14 bp heterozygous genotype with p-value: 0.49) nor the HLA-E genotypes (HLA-E*0101/0103, HLA-E*0101/0101, and HLA-E*0103/0103 with the p-values: 0.152, 0.249, and 0.391, respectively) had any association with CMV reinfection in the LTRs.
Conclusion: No difference was observed in the HLA-E and HLA-G genotype frequencies between our studied groups. Further studies are needed to explore other genetic variations and evaluate soluble HLA-G and HLA-E levels in the transplant population.
کلیدواژه‌ها
Acute Rejection؛ Cytomegalovirus؛ Liver Transplantation؛ Non-classical HLA
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