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Enzyme-Assisted Extraction of Narirutin from Citri Reticulatae Pericarpium and Anti-allergic Asthma Activity | ||
| Iranian Journal of Immunology | ||
| دوره 19، شماره 4، اسفند 2022، صفحه 385-394 اصل مقاله (2.02 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2022.91640.2095 | ||
| نویسندگان | ||
| Xiaolei Shi1؛ Lina Zhao1؛ Liyan Niu1؛ Jhao Wei1؛ Xuwen Li2؛ Yongri Jin* 2 | ||
| 1College of Food Science and Engineering, Jilin University, Changchun, China | ||
| 2College of Chemistry, Jilin University, Changchun, China | ||
| چکیده | ||
| Background: Asthma is a heterogeneous disorder of the airways related to inflammation; it affects millions of people worldwide. Due to the side effects of inhaled corticosteroids, researchers focused on the therapeutic effects of compounds derived from natural products. Objective: To investigate the therapeutic benefits of Narirutin a valuable flavonoid in Citri Reticulatae Pericarpium for asthma. Methods: Narirutin was extracted using the enzyme-assisted method with the L9 (34) orthogonal array to optimize the temperatures, pH, and reaction time. The mechanism of action of Narirutin was investigated via ELISA, flow cytometry, and Western blot analysis in vivo. Results: Narirutin suppressed inflammatory cell infiltration in the lung tissue and decreased IgE and IgG1 levels in serum in vivo. It can also alleviate interleukin (IL)-4, IL-5, and interferon-γ concentrations in bronchoalveolar lavage fluid in mice. Moreover, it increased the ratio of CD4+/CD8+ T cells. Additionally, Narirutin significantly suppressed p-ERK1/2 and p-JNK expression in the MAPK signaling pathway. Conclusion: Narirutin affects the Th1/Th2 imbalance through the p-ERK and p-JNK suppression in the MAPK signaling pathway. | ||
| کلیدواژه‌ها | ||
| Allergy؛ Citri Reticulatae Pericarpium؛ Immunology؛ Inflammation؛ Narirutin | ||
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آمار تعداد مشاهده مقاله: 934 تعداد دریافت فایل اصل مقاله: 872 |
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