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The Relationship between Structure of the Corticoreticular Tract and Walking Capacity in Children with Cerebral Palsy | ||
Journal of Biomedical Physics and Engineering | ||
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 11 دی 1401 اصل مقاله (867.31 K) | ||
نوع مقاله: Original Research | ||
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2104-1302 | ||
نویسندگان | ||
Shahla Azizi1، 2؛ Parmida Moradi Birgani3؛ Meghdad Ashtiani4؛ Ashkan Irani5؛ Amin Shahrokhi6؛ Khadijeh Meydanloo7؛ Mohammad Mehdi Mirbagheri1، 8 | ||
1Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical, Tehran, Iran | ||
2Department of Electrical and Electronic Engineering, Eastern Mediterranean University, Famagusta, Northern Cyprus, Mersin 10, Turkey | ||
3PhD, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical, Tehran, Iran | ||
4Department of Occupational Therapy, Faculty of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
5Department of Occupational Therapy, Faculty of Rehabilitation, Shahid Beheshti University of Medical Sciences Health Services, Tehran, Iran | ||
6Tehran University of Medical Sciences, TehrFaculty of Medicine, Tehran University of Medical, Tehran, Iran an, Iran | ||
7School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
8Department of Physical Medicine and Rehabilitation, Northwestern University, Evanston, United States | ||
چکیده | ||
Background: Disruption in the descending pathways may lead to gait impairments in Cerebral Palsy (CP) children. Though, the mechanisms behind walking problems have not been completely understood. Objective: We aimed to define the relationship between the structure of the corticoreticular tract (CRT) and walking capacity in children with CP. Material and Methods: This is a retrospective, observational, and cross-sectional study. Twenty-six children with CP between 4 to 15 years old participated. Also, we used existed data of healthy children aged 4 to 15 years old. CRT structure was characterized using diffusion tensor imaging (DTI). The DTI parameters extracted to quantify CRT structure included: fractional anisotropy (FA), mean (MD), axial (AD), and radial (RD) diffusivity. Balance and walking capacity was evaluated using popular clinical measures, including the Berg balance scale (BBS), Timed-Up-and-Go (TUG; balance and mobility), six-minute walk test (6 MWT; gait endurance), and 10-meter walk Test (10 MWT; gait speed). Results: There are significant differences between MD, AD, and RD in CP and healthy groups. Brain injury leads to various patterns of the CRT structure in children with CP. In the CP group with abnormal CRT patterns, DTI parameters of the more affected CRT are significantly correlated with walking balance, speed, and endurance measures. Conclusion: Considering the high inter-subject variability, the variability of CRT patterns is vital for determining the nature of changes in CRT structure, their relationship with gait impairment, and understanding the underlying mechanisms of movement disorders. This information is also important for the development or prescription of an effective rehabilitation target for individualizing treatment. | ||
کلیدواژهها | ||
Diffusion Tensor Imaging؛ Motor pathway؛ Muscle Weakness؛ Muscle Spasticity؛ Cerebral Palsy | ||
آمار تعداد مشاهده مقاله: 114 تعداد دریافت فایل اصل مقاله: 142 |