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Lestari, Catur, Pustika Dewi, Restu Ayu Eka, Nurjanah, Siti, Sabarani, Lusiana Cici, Resputri, Fibra. (1401). The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome. سامانه مدیریت نشریات علمی, 7(4), 210-216. doi: 10.30476/ijns.2022.97406.1209
Catur Retno Lestari; Restu Ayu Eka Pustika Dewi; Siti Nurjanah; Lusiana Cici Sabarani; Fibra Resputri. "The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome". سامانه مدیریت نشریات علمی, 7, 4, 1401, 210-216. doi: 10.30476/ijns.2022.97406.1209
Lestari, Catur, Pustika Dewi, Restu Ayu Eka, Nurjanah, Siti, Sabarani, Lusiana Cici, Resputri, Fibra. (1401). 'The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome', سامانه مدیریت نشریات علمی, 7(4), pp. 210-216. doi: 10.30476/ijns.2022.97406.1209
Lestari, Catur, Pustika Dewi, Restu Ayu Eka, Nurjanah, Siti, Sabarani, Lusiana Cici, Resputri, Fibra. The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome. سامانه مدیریت نشریات علمی, 1401; 7(4): 210-216. doi: 10.30476/ijns.2022.97406.1209

The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome

International Journal of Nutrition Sciences
مقاله 4، دوره 7، شماره 4، اسفند 2022، صفحه 210-216    اصل مقاله (410.85 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2022.97406.1209
نویسندگان
Catur Retno Lestari* 1؛ Restu Ayu Eka Pustika Dewi1؛ Siti Nurjanah2؛ Lusiana Cici Sabarani2؛ Fibra Resputri2
1Department of Biomedical Science, Faculty of Health, Ivet University, Central Java , Indonesia
2Student Program of Biomedical Science, Faculty of Health, Ivet University, Central Java, Indonesia
چکیده
Background: Green coffee seed (Coffea canephora) are rich in polyphenolic compounds and yellow turmeric (Curcuma domestica val.) is rich in curcuminoids and essential oils. This study determined the combination effect of green coffee seed and yellow turmeric extracts on TNF-α in acute respiratory distress syndrome (ARDS) in rat model.
Methods: Thirty rats were randomly grouped into five equal groups of 5 rats. Control group received normal diet and distilled water, positive control was administered with 0.8 mg/kg of LPS to induce ARDS in absence of any treatment, Treatment group 1 received 200 mg/kg/day of the combination of green coffe seed and yellow tumeric extract intraperitoneally (IP) for 14 days, Treatment group 2 was given 400 mg/kg/day of the combination similarly, and treatment group 3 was injected with 600 mg/kg/day of the combination identically. TNF-α level was
compared between groups.
Results: The combination of green coffee seed and yellow turmeric extract (400 mg/kg/day) given for 14 days could significantly decrease TNF-α level in rats after induction of ARDS (p˂0.05).
Conclusion: A combination of green coffee seed (C. canephora) and yellow turmeric (C. domestica Val.) extract can be considered a therapeutic choice in ARDS.
کلیدواژه‌ها
Green Coffee Bean؛ Yellow Turmeric؛ TNF-α؛ Respiratory distress syndrome (ARDS)؛ Rat
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