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Dastgheib, Ladan, Rostams, Farima, Gharesi-Fard, Behrouz, Asadi-Pooya, Ali Akbar, Namjoo, Saba, Tahmasebi, Foroozan, Hadibarhaghtalab, Maryam. (1401). Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study. سامانه مدیریت نشریات علمی, 48(1), 70-76. doi: 10.30476/ijms.2022.91192.2241
Ladan Dastgheib; Farima Rostams; Behrouz Gharesi-Fard; Ali Akbar Asadi-Pooya; Saba Namjoo; Foroozan Tahmasebi; Maryam Hadibarhaghtalab. "Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study". سامانه مدیریت نشریات علمی, 48, 1, 1401, 70-76. doi: 10.30476/ijms.2022.91192.2241
Dastgheib, Ladan, Rostams, Farima, Gharesi-Fard, Behrouz, Asadi-Pooya, Ali Akbar, Namjoo, Saba, Tahmasebi, Foroozan, Hadibarhaghtalab, Maryam. (1401). 'Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study', سامانه مدیریت نشریات علمی, 48(1), pp. 70-76. doi: 10.30476/ijms.2022.91192.2241
Dastgheib, Ladan, Rostams, Farima, Gharesi-Fard, Behrouz, Asadi-Pooya, Ali Akbar, Namjoo, Saba, Tahmasebi, Foroozan, Hadibarhaghtalab, Maryam. Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study. سامانه مدیریت نشریات علمی, 1401; 48(1): 70-76. doi: 10.30476/ijms.2022.91192.2241

Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study

Iranian Journal of Medical Sciences
مقاله 9، دوره 48، شماره 1، فروردین 2023، صفحه 70-76    اصل مقاله (260.37 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.91192.2241
نویسندگان
Ladan Dastgheib1؛ Farima Rostams2؛ Behrouz Gharesi-Fard3؛ Ali Akbar Asadi-Pooya4، 5؛ Saba Namjoo6؛ Foroozan Tahmasebi3؛ Maryam Hadibarhaghtalab* 1
1Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA
6Blood Transfusion Research Center, High Institute for Education and Research in Transfusion Medicine, Tehran, Iran
چکیده
Background: Genetic diversity in human leukocyte antigen (HLA) alleles across populations is a significant risk factor for drug-induced severe cutaneous adverse reactions (SCARs), e.g., carbamazepine (CBZ)- and lamotrigine (LTG)-induced Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The present study aimed to investigate the frequency of different HLA alleles in Iranian patients with CBZ- and LTG-induced SJS/TEN.
Methods: A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and divided into two groups. The drug-induced group (n=14) included hospitalized patients due to CBZ- or LTG-induced SJS/TEN. The drug-tolerant group (n=17) included individuals receiving CBZ or LTG for at least three months with no adverse effects. In addition, 46 healthy individuals (control group) were recruited. The frequency of HLA-A, -B, and -DRB1 alleles in patients with CZB- or LTG-induced SJS/TEN was investigated. HLA typing was performed using the allele-specific polymerase chain reaction method. The Chi square test and Fisher’s exact test were used to determine a potential association between SJS/TEN and HLA alleles. P<0.05 was considered statistically significant.
Results: CBZ- or LTG-induced SJS/TEN was not significantly associated with HLA alleles. However, HLA-DRB1*01 showed a significantly higher frequency in patients with CBZ-induced SJS/TEN than the CBZ-tolerant patients (30% vs. 9%, P=0.07). 
Conclusion: Overall, no significant association was found between CBZ- or LTG-induced SJS/TEN and HLA alleles. Further large-scale studies are required to substantiate our findings.
کلیدواژه‌ها
Stevens-Johnson syndrome؛ Anticonvulsants؛ Histocompatibility testing
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مراجع
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