Dexamethasone Blunts Lung Inflammation in Cholestatic Mice | ||
| Trends in Pharmaceutical Sciences and Technologies | ||
| مقاله 1، دوره 9، شماره 1، بهار 2023، صفحه 1-14 اصل مقاله (905.05 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/tips.2022.96046.1155 | ||
| نویسندگان | ||
| Hossein Niknahad1، 2؛ Narges Abdoli3؛ Mohammad Mehdi Ommati1، 4، 5؛ Asma Najibi2؛ Ardeshir Zare2، 6؛ Sahra Mazloomi2، 6؛ Issa Sadeghian1، 7؛ Khadijeh Mousavi2؛ Negar Azarpira8؛ Reza Heidari* 1 | ||
| 1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Food and Drug Administration, Iran Ministry of Health and Medical Education, Tehran, Iran | ||
| 4Department of Life Sciences, Shanxi Agricultural University, Shanxi, Taigu, China | ||
| 5Henan Key Laboratory of Environmental and Animal Product Safety College of Animal Science and Technology Henan University of Science and Technology Luoyang 471000 Henan, China | ||
| 6Students Research Committee, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 7Biotechnology Incubator, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Cholestasis/cirrhosis is a multifaceted clinical complication that influences many organs, including the liver, kidney, heart, skeletal muscle, and lung. Cirrhosis-associated lung injury could lead to severe and lethal consequences, including acute respiratory syndrome and patient dearth. Unfortunately, there is no specific pharmacological intervention to manage cholestasis-induced lung injury. It has been revealed that severe inflammation and its associated complications, such as oxidative stress, are involved in the pathogenesis of cholestasis-associated pulmonary damage. The current study was designed to evaluate the role of dexamethasone (DXM) on lung inflammation in cholestatic mice. For this purpose, bile duct ligated (BDL) mice received DXM (1 and 2.5 mg/kg, i.p, 2 times/week) for 14 days. On day 15, the bronchoalveolar lavage fluid (BALF) was prepared. Several markers, including inflammatory cell infiltration, TNF-α, and IgG, were assessed in the BALF of BDL animals. Significant infiltration of inflammatory cells along with increased TNF-α and IgG were detected in the BALF of BDL mice (14 days after surgery). Moreover, significant ROS formation, glutathione depletion, lipid peroxidation, and protein carbonylation were evident in the lung tissue of the BDL group. It was found that DXM (1 and 2.5 mg/kg) significantly blunted inflammation and oxidative stress in the lung of cholestatic mice. Moreover, lung tissue histopathological changes, including inflammatory cell infiltration, were significantly mitigated in DXM-treated mice. These data offer the potential therapeutic effects of DXM against cholestasis-related complications. Therefore, patients with cholestasis-induced lung injury might benefit from repurposing DXM in clinical settings. | ||
| کلیدواژهها | ||
| Bile acid؛ Inflammation؛ Lung injury؛ Oxidative stress؛ Pulmonary disease | ||
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