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Irani, Soussan, Alimohammadi, Shohreh, Najafian, Tahmineh. (1401). Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/dentjods.2022.95201.1845
Soussan Irani; Shohreh Alimohammadi; Tahmineh Najafian. "Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.30476/dentjods.2022.95201.1845
Irani, Soussan, Alimohammadi, Shohreh, Najafian, Tahmineh. (1401). 'Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/dentjods.2022.95201.1845
Irani, Soussan, Alimohammadi, Shohreh, Najafian, Tahmineh. Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.30476/dentjods.2022.95201.1845

Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ

Journal of Dentistry
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 آذر 1401  XML اصل مقاله (1.05 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2022.95201.1845
نویسندگان
Soussan Irani email orcid 1؛ Shohreh Alimohammadiorcid 2؛ Tahmineh Najafian3
1Dept. of Oral Pathology, Dental Faculty, Dental Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Lecturer at Griffith University, Gold Coast, Australia.
2Gynecologist and Perinatologist, Hamadan University of Medical Sciences, Hamadan, Iran.
3Dentist, Private Clinic, Hamadan, Iran.
چکیده
Statement of the Problem: Enamel organ (EO) is an ectodermal derived structure, which is involved in the different aspects of tooth development. Tooth development shares the same regulatory molecules and genes expressed in other developing organs. Endothelin- 1 (ET-1) and Endothelin A receptor (ETAR), (ET-1/ETAR) axis, are involved in differentiation of embryonic stem cells and organ development.
Purpose: The present study aimed to investigate the ET-1 and ETAR expression profiles during the development of human primary tooth EO with the relatively large sample size.
Materials and Method: In this experimental study, 33 human fetuses aged from 13 to 23 weeks (3 samples from each fetal age) were collected. The samples were divided into three age groups (<16 weeks, <19 weeks, ≥19 weeks) and cut for hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining. A two-way ANOVA test was conducted to examine the expression levels of ET-1 and ETAR in different layers of human primary tooth EO. The statistical significance was assumed at p ≤ 0.05.
Results: There were statistically significant differences between the expression levels of ET-1/ETAR axis in the four-layered human primary tooth EO in different fetal ages (13-23 weeks). Besides, there were significant differences between the expression levels of ET-1/ETAR axis in all layers of human primary enamel organ and types of teeth.
Conclusion: Due to the profile of expression of ET-1/ETAR axis, it can be concluded that this axis contributes to the differentiation of all human primary EO layers and secretion of enamel. ET-1/ETAR axis is one of the signaling molecules, which may have crucial roles in tooth development. 
کلیدواژه‌ها
Embryology؛ Enamel organ؛ Endothelin-1؛ Odontogenesis
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