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Nnamani, Didacus, Eraga, Sylvester. (1401). Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration. سامانه مدیریت نشریات علمی, 8(4), 243-252. doi: 10.30476/tips.2022.96659.1168
Didacus Nnabuike Nnamani; Sylvester Eraga. "Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration". سامانه مدیریت نشریات علمی, 8, 4, 1401, 243-252. doi: 10.30476/tips.2022.96659.1168
Nnamani, Didacus, Eraga, Sylvester. (1401). 'Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration', سامانه مدیریت نشریات علمی, 8(4), pp. 243-252. doi: 10.30476/tips.2022.96659.1168
Nnamani, Didacus, Eraga, Sylvester. Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration. سامانه مدیریت نشریات علمی, 1401; 8(4): 243-252. doi: 10.30476/tips.2022.96659.1168

Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration

Trends in Pharmaceutical Sciences
مقاله 4، دوره 8، شماره 4، اسفند 2022، صفحه 243-252    اصل مقاله (525.94 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.96659.1168
نویسندگان
Didacus Nnabuike Nnamani* 1؛ Sylvester Eraga2
1Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Igbinedion University, Okada, Edo State, Nigeria.
2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria.
چکیده
Co-processing techniques have been used to modify the properties of dosage forms. The aim of this study is to evaluate the granules and tablet properties of co-processed paracetamol, gelatin and microcrystalline cellulose. Batches of co-processed paracetamol granules (A-E) were prepared by melt-in agglomeration process using paracetamol with varying amounts of gelatin (1.0, 2.0, 3.0 or 4.0 % w/w) or starch (3.0 % w/w) and microcrystalline cellulose. A control batch (F) of conventional granules was also prepared by wet granulation method with starch mucilage (4.0 % w/w). The granules were subjected to micromeritic, compaction and differential scanning calorimetric analyses. The granules were compressed into tablets and their tablet properties evaluated. Granules of batches A-D had higher percent maximum volume reduction of 12.25-16.13 % compared to the percent maximum volume-reduction (9.52 and 11.81) of granules from batches E and F respectively. Differential scanning result indicates amorphous solidification of co-processed paracetamol. Tablets formulated from batches A-D showed improve tensile strength (3.63 - 8.26 Nm-2) and faster disintegration time (1.32- 1.12 min) compared to the tensile strengths (5.09 & 5.01 Nm-2) and disintegration times (2.54 & 4.43 min) of tablets from batches E and F respectively. There were no significant difference (P≥0.05) in their maximum amounts ( >70 %) of drug released after 40 min. Melt-in agglomeration of paracetamol and gelatin with microcrystalline cellulose created amorphous dispersion that improved tabletability parameters of granules and disintegration time and dissolution properties of tablets.
کلیدواژه‌ها
Co-processed؛ compaction؛ maximum volume-reduction؛ amorphous solidification؛ tabletability
مراجع
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