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Omidvar, Mojtaba, Tahmasebi, Sedigheh, Akrami, Majid, Arasteh, Payam, Zangouri, Vahid, Safaei, Akbar, Hosseini, Sara, Salehi Nobandegani, Aida, Hosseini, Seyed Morteza, Talei, Abdolrasoul. (1401). Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry. سامانه مدیریت نشریات علمی, 14(1), 119-126. doi: 10.30476/mejc.2022.92135.1647
Mojtaba Omidvar; Sedigheh Tahmasebi; Majid Akrami; Payam Arasteh; Vahid Zangouri; Akbar Safaei; Sara Hosseini; Aida Salehi Nobandegani; Seyed Morteza Hosseini; Abdolrasoul Talei. "Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry". سامانه مدیریت نشریات علمی, 14, 1, 1401, 119-126. doi: 10.30476/mejc.2022.92135.1647
Omidvar, Mojtaba, Tahmasebi, Sedigheh, Akrami, Majid, Arasteh, Payam, Zangouri, Vahid, Safaei, Akbar, Hosseini, Sara, Salehi Nobandegani, Aida, Hosseini, Seyed Morteza, Talei, Abdolrasoul. (1401). 'Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry', سامانه مدیریت نشریات علمی, 14(1), pp. 119-126. doi: 10.30476/mejc.2022.92135.1647
Omidvar, Mojtaba, Tahmasebi, Sedigheh, Akrami, Majid, Arasteh, Payam, Zangouri, Vahid, Safaei, Akbar, Hosseini, Sara, Salehi Nobandegani, Aida, Hosseini, Seyed Morteza, Talei, Abdolrasoul. Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry. سامانه مدیریت نشریات علمی, 1401; 14(1): 119-126. doi: 10.30476/mejc.2022.92135.1647

Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry

Middle East Journal of Cancer
مقاله 12، دوره 14، شماره 1 - شماره پیاپی 53، فروردین 2023، صفحه 119-126    اصل مقاله (874.19 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2022.92135.1647
نویسندگان
Mojtaba Omidvar1؛ Sedigheh Tahmasebi* 1؛ Majid Akrami1؛ Payam Arasteh1، 2؛ Vahid Zangouri1؛ Akbar Safaei3؛ Sara Hosseini1؛ Aida Salehi Nobandegani1؛ Seyed Morteza Hosseini4؛ Abdolrasoul Talei1
1Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Foreign Languages and Linguistics, Shiraz University, Shiraz, Iran
3Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
4Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
چکیده
Background: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.
Method: This cross-sectional research is a part of Shiraz Breast Cancer Registry (SBCR). We studied all the patients in the SBCR (n=6145). Ultrasound reports were used to differentiate between MMBCs and unifocal breast cancers (BCs). All the patients were examined with mammography and the diagnosis was confirmed postoperatively via pathology reports.
Results: After exclusion, 4045 patients entered the study (n=1072 and n=2973 for multifocal/multicentric and unifocal BCs, respectively). The mean follow-up period was 57.9 (0.27-275) months. Patients with MMBCs had higher rates of mastectomy (48% vs. 40.1%; P < 0.001) and higher rates of HER-2 overexpression (32.1% vs. 26%; P = 0.001) compared with those with unifocal BCs. Tumor size, lymph node involvement, type of axillary management, chemotherapy, radiotherapy, hormonal therapy, recurrence rates, histological grade, lymphovascular invasion, axillary node involvement, estrogen and progesterone receptor expression status, tumor, node, and metastasis staging were not significantly different between the groups. Five-year overall survival was 88.3% and 89% (P = 0.8) for unifocal and MMBCs, respectively; moreover, five-year disease-free survival was 80.2% and 81.2% (P = 0.41), respectively.
Conclusion: Despite the controversy regarding prognosis and surgical management in MMBCs, we found that MMBCs had similar clinicopathological features and prognosis compared to unifocal BCs. Survival, recurrence, and metastasis were similar among the two groups.
کلیدواژه‌ها
Breast neoplasm؛ Staging؛ Survival؛ Multicentricity؛ Multifocality
مراجع
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