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Roayaei, Mahnaz, Nazeminezhad, Nooshin, Najafizade, Nadia, Sharifi, Mehran. (1402). The Efficacy and Safety of Captopril in Preventing Capecitabine-induced Hand-foot Syndrome: A Randomized Double-blinded Placebo-controlled Clinical Trial. سامانه مدیریت نشریات علمی, 14(2), 292-299. doi: 10.30476/mejc.2022.93268.1680
Mahnaz Roayaei; Nooshin Nazeminezhad; Nadia Najafizade; Mehran Sharifi. "The Efficacy and Safety of Captopril in Preventing Capecitabine-induced Hand-foot Syndrome: A Randomized Double-blinded Placebo-controlled Clinical Trial". سامانه مدیریت نشریات علمی, 14, 2, 1402, 292-299. doi: 10.30476/mejc.2022.93268.1680
Roayaei, Mahnaz, Nazeminezhad, Nooshin, Najafizade, Nadia, Sharifi, Mehran. (1402). 'The Efficacy and Safety of Captopril in Preventing Capecitabine-induced Hand-foot Syndrome: A Randomized Double-blinded Placebo-controlled Clinical Trial', سامانه مدیریت نشریات علمی, 14(2), pp. 292-299. doi: 10.30476/mejc.2022.93268.1680
Roayaei, Mahnaz, Nazeminezhad, Nooshin, Najafizade, Nadia, Sharifi, Mehran. The Efficacy and Safety of Captopril in Preventing Capecitabine-induced Hand-foot Syndrome: A Randomized Double-blinded Placebo-controlled Clinical Trial. سامانه مدیریت نشریات علمی, 1402; 14(2): 292-299. doi: 10.30476/mejc.2022.93268.1680

The Efficacy and Safety of Captopril in Preventing Capecitabine-induced Hand-foot Syndrome: A Randomized Double-blinded Placebo-controlled Clinical Trial

Middle East Journal of Cancer
مقاله 11، دوره 14، شماره 2 - شماره پیاپی 54، تیر 2023، صفحه 292-299    اصل مقاله (1.79 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2022.93268.1680
نویسندگان
Mahnaz Roayaei1؛ Nooshin Nazeminezhad2؛ Nadia Najafizade* 1؛ Mehran Sharifi3
1Radiation Oncology Department, Isfahan University of Medical Sciences, Isfahan, Iran
2Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Hematology Oncology Department, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Hand-foot syndrome (HFS) is a prevalent skin reaction to cytotoxic systemic therapy, mainly Capecitabine.
The present study aimed to determine etiologies of HFS in addition to its prevention in colorectal cancer patients with Capecitabine-containing chemotherapy regimen.
Method: In this randomized double-blinded study, we recruited 66 eligible patients. The first 33 patients received 25 mg captopril twice daily, while the other 33 were given two placebo tablets.
Results: All the patients were assessable for safety and efficacy. Captopril demonstrated a favorable safety profile. The participants in the two groups did not have any significant differences in terms of the median age and the level of hemoglobin (P = 0.45, P = 0.06, respectively). However, the CEA tumor marker was significantly higher in those with HFS (P < 0.05). The incidence of HFS in men and women were 8 (18.6%) and 3 (13%) cases, respectively, and the patients’ sex did not affect the incidence of this syndrome (P = 0.73).
Furthermore, according to the stage of colorectal cancer, the difference between the two groups was significant (P < 0.05). Meanwhile, there were no significant differences concerning the grade of colorectal cancer (P = 0.2).
Conclusion: The results herein revealed that administration of captopril in colorectal cancer patients with Capecitabine-containing chemotherapy regimen reduced the symptoms and incidence of HFS.
On the other hand, CEA tumor marker and the stage of colorectal cancer were in correlation with incidence of HFS.
کلیدواژه‌ها
Hand-foot syndrome؛ Capecitabine؛ Captopril
مراجع
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