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Amraee, Azadeh, Sarikhani, Abolfazl, Darvish, Leili, Alamzadeh, Zahr, Irajirad, Rasoul, Mahdavi, Seyed Rabie. (1401). Curcumin Coated Ultra-Small Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging of Cancer Cells. سامانه مدیریت نشریات علمی, (), -. doi: 10.31661/jbpe.v0i0.2201-1447
Azadeh Amraee; Abolfazl Sarikhani; Leili Darvish; Zahr Alamzadeh; Rasoul Irajirad; Seyed Rabie Mahdavi. "Curcumin Coated Ultra-Small Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging of Cancer Cells". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.31661/jbpe.v0i0.2201-1447
Amraee, Azadeh, Sarikhani, Abolfazl, Darvish, Leili, Alamzadeh, Zahr, Irajirad, Rasoul, Mahdavi, Seyed Rabie. (1401). 'Curcumin Coated Ultra-Small Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging of Cancer Cells', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.31661/jbpe.v0i0.2201-1447
Amraee, Azadeh, Sarikhani, Abolfazl, Darvish, Leili, Alamzadeh, Zahr, Irajirad, Rasoul, Mahdavi, Seyed Rabie. Curcumin Coated Ultra-Small Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging of Cancer Cells. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.31661/jbpe.v0i0.2201-1447

Curcumin Coated Ultra-Small Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging of Cancer Cells

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 02 آبان 1401    اصل مقاله (1.19 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2201-1447
نویسندگان
Azadeh Amraee* 1؛ Abolfazl Sarikhani2؛ Leili Darvish3؛ Zahr Alamzadeh2؛ Rasoul Irajirad2؛ Seyed Rabie Mahdavi4
1PhD Candidate, Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
2MSc, Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
3PhD Candidate, Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4PhD, Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background: The application of nanotechnology in the molecular diagnosis and treatment of cancer is essential. 
Objective: This study aimed to investigate the influence of curcumin-coated ultra-small superparamagnetic iron oxide (USPIO) as a T1 contrast agent in Magnetic Resonance Imaging (MRI). .
Material and Methods: In this experimental study, the influence of curcumin-coated USPIO (Fe3O4@C) on the diagnosis of the cancer cell line was investigated. After synthesis, characterization, and relaxation of Fe3O4@C, the contrast changes in T1-weight MRI to mouse colon carcinoma 26 cell line were evaluated in vitro. 
Results: Fe3O4@C nanoparticles (NPs) are good at imaging; based on a relaxometry test, the r1 and r2 relaxivities of Dotarem were 3.139 and 0.603 mM−1s−1, respectively. Additionally, the r1 and r2 relaxivities of Fe3O4@C were 3.792 and 1.3 mM−1s−1, respectively, with the rate of 2.155 of r2/r1 NPs.  
Conclusion: The NPs can be identified as a positive contrast agent with a weight of T1 in MRI. The coresh-ell Fe3O4@C NPs can be effective in cancer treatment and diagnosis because of the therapeutic effects of curcumin and the properties of USPIO.
کلیدواژه‌ها
Ultra-small Iron Oxide؛ Nanoparticles؛ Curcumin؛ Magnetic Resonance Imaging؛ Contrast Agent
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