LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,084
تعداد دریافت فایل اصل مقاله11,291,752
Moftian, Nazila, Samad Soltani, Taha, Mirnia, Kayvan, Esfandiari, Atefeh, Tabib, Mohammad Saleh, Rezaei Hachesu, Peyman. (1401). Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study. سامانه مدیریت نشریات علمی, 48(1), 57-69. doi: 10.30476/ijms.2022.92284.2352
Nazila Moftian; Taha Samad Soltani; Kayvan Mirnia; Atefeh Esfandiari; Mohammad Saleh Tabib; Peyman Rezaei Hachesu. "Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study". سامانه مدیریت نشریات علمی, 48, 1, 1401, 57-69. doi: 10.30476/ijms.2022.92284.2352
Moftian, Nazila, Samad Soltani, Taha, Mirnia, Kayvan, Esfandiari, Atefeh, Tabib, Mohammad Saleh, Rezaei Hachesu, Peyman. (1401). 'Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study', سامانه مدیریت نشریات علمی, 48(1), pp. 57-69. doi: 10.30476/ijms.2022.92284.2352
Moftian, Nazila, Samad Soltani, Taha, Mirnia, Kayvan, Esfandiari, Atefeh, Tabib, Mohammad Saleh, Rezaei Hachesu, Peyman. Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study. سامانه مدیریت نشریات علمی, 1401; 48(1): 57-69. doi: 10.30476/ijms.2022.92284.2352

Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study

Iranian Journal of Medical Sciences
مقاله 8، دوره 48، شماره 1، فروردین 2023، صفحه 57-69    اصل مقاله (387.72 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.92284.2352
نویسندگان
Nazila Moftian1؛ Taha Samad Soltani1؛ Kayvan Mirnia2؛ Atefeh Esfandiari3؛ Mohammad Saleh Tabib4؛ Peyman Rezaei Hachesu* 1
1Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran
2Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3Department of Health Policy and Management, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4Department of Pediatrics, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
چکیده
Background: Despite growing evidence, there is still uncertainty about potentially modifiable risk factors for neonatal early-onset sepsis (EOS). This study aimed to identify potential clinical risk factors for EOS based on a literature review and expert opinions.
Methods: A literature search was conducted in PubMed (MEDLINE), Cochrane, Embase, and Scopus databases. Articles in English, published up to May 2021, on clinical risk factors for neonatal EOS were included. Initially, a questionnaire on risk factors for EOS was developed and validated. The fuzzy Delphi method (FDM) was used to formulate the final version of the questionnaire. The validity of the risk factors was assessed using the Chi square test. P<0.05 was considered statistically significant.
Results: In the review phase, 30 risk factors were approved by two neonatologists and included in the FDM phase. In total, 25 risk factors met the consensus criteria and entered the validation phase. During the observational study, 114 neonates (31 with and 83 without EOS) were evaluated for two months. The results of the Chi square test showed that cesarean section was not a significant risk factor for EOS (P=0.862). The need for mechanical ventilation and feed intolerance was observed in about 70% of neonates with EOS, and therefore considered significant risk factors for EOS (P<0.001). Finally, 26 potential clinical risk factors were determined.
Conclusion: Neonatal-related risk factors for EOS were birth weight, one-min Apgar score, and prematurity. Maternal-related risk factors were gestational age and urinary tract infection. Delivery-related risk factors were premature rupture of membranes, chorioamnionitis, and intrapartum fever.
کلیدواژه‌ها
Neonatal sepsis؛ Risk factors؛ Infections؛ Infant؛ Newborn
سایر فایل های مرتبط با مقاله
مراجع
  1. Adatara P, Afaya A, Salia SM, Afaya RA, Konlan KD, Agyabeng-Fandoh E, et al. Risk Factors Associated with Neonatal Sepsis: A Case Study at a Specialist Hospital in Ghana. ScientificWorldJournal. 2019;2019:9369051. doi: 10.1155/2019/9369051. PubMed PMID: 30692878; PubMed Central PMCID: PMCPMC6332869.
  2. Caffrey Osvald E, Prentice P. NICE clinical guideline: antibiotics for the prevention and treatment of early-onset neonatal infection. Arch Dis Child Educ Pract Ed. 2014;99:98-100. doi: 10.1136/archdischild-2013-304629. PubMed PMID: 24334339.
  3. Villamor-Martinez E, Lubach GA, Rahim OM, Degraeuwe P, Zimmermann LJ, Kramer BW, et al. Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression. Front Immunol. 2020;11:972. doi: 10.3389/fimmu.2020.00972. PubMed PMID: 32582153; PubMed Central PMCID: PMCPMC7289970.
  4. Yismaw AE, Abebil TY, Biweta MA, Araya BM. Proportion of neonatal sepsis and determinant factors among neonates admitted in University of Gondar comprehensive specialized hospital neonatal Intensive care unit Northwest Ethiopia 2017. BMC Res Notes. 2019;12:542. doi: 10.1186/s13104-019-4587-3. PubMed PMID: 31455414; PubMed Central PMCID: PMCPMC6712769.
  5. Verani JR, McGee L, Schrag SJ, Division of Bacterial Diseases NCfI, Respiratory Diseases CfDC, Prevention. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59:1-36. PubMed PMID: 21088663.
  6. Khan MJ, Kumam P, Liu P, Kumam W, Ashraf S. A novel approach to generalized intuitionistic fuzzy soft sets and its application in decision support system. Mathematics. 2019;7:742. doi: 10.1016/j.ins.2012.09.010.
  7. McPherson S, Reese C, Wendler MC. Methodology Update: Delphi Studies. Nurs Res. 2018;67:404-10. doi: 10.1097/NNR.0000000000000297. PubMed PMID: 30052591.
  8. Araújo BC, Guimarães H. Risk factors for neonatal sepsis: an overview. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM). 2020;9:e090206.
  9. Adatara P, Afaya A, Salia SM, Afaya RA, Kuug AK, Agbinku E, et al. Risk Factors for Neonatal Sepsis: A Retrospective Case-Control Study among Neonates Who Were Delivered by Caesarean Section at the Trauma and Specialist Hospital, Winneba, Ghana. Biomed Res Int. 2018;2018:6153501. doi: 10.1155/2018/6153501. PubMed PMID: 30662911; PubMed Central PMCID: PMCPMC6313993.
  10. Hayun M, Alasiry E, Daud D, Febriani DB, Madjid D. The risk factors of early onset neonatal sepsis. American Journal of clinical and experimental medicine. 2015;3:78-82. doi: 10.11648/j.ajcem.20150303.11.
  11. Polcwiartek LB, Smith PB, Benjamin DK, Zimmerman K, Love A, Tiu L, et al. Early-onset sepsis in term infants admitted to neonatal intensive care units (2011-2016). J Perinatol. 2021;41:157-63. doi: 10.1038/s41372-020-00860-3. PubMed PMID: 33070153; PubMed Central PMCID: PMCPMC7568457.
  12. Akalu TY, Gebremichael B, Desta KW, Aynalem YA, Shiferaw WS, Alamneh YM. Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study. PLoS One. 2020;15:e0234472. doi: 10.1371/journal.pone.0234472. PubMed PMID: 32579580; PubMed Central PMCID: PMCPMC7314009.
  13. Salem SY, Sheiner E, Zmora E, Vardi H, Shoham-Vardi I, Mazor M. Risk factors for early neonatal sepsis. Arch Gynecol Obstet. 2006;274:198-202. doi: 10.1007/s00404-006-0135-1. PubMed PMID: 16491366.
  14. Gebremedhin D, Berhe H, Gebrekirstos K. Risk Factors for Neonatal Sepsis in Public Hospitals of Mekelle City, North Ethiopia, 2015: Unmatched Case Control Study. PLoS One. 2016;11:e0154798. doi: 10.1371/journal.pone.0154798. PubMed PMID: 27163290; PubMed Central PMCID: PMCPMC4862626.
  15. Siakwa M, Kpikpitse D, Mupepi SC, Semuatu M. Neonatal sepsis in rural Ghana: A case control study of risk factors in a birth cohort. International Journal of Research. 2014;4:2307-83.
  16. Klinger G, Levy I, Sirota L, Boyko V, Reichman B, Lerner-Geva L, et al. Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants. Am J Obstet Gynecol. 2009;201:38 e1-6. doi: 10.1016/j.ajog.2009.03.006. PubMed PMID: 19380122.
  17. Giannoni E, Agyeman PKA, Stocker M, Posfay-Barbe KM, Heininger U, Spycher BD, et al. Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study. J Pediatr. 2018;201:106-14. doi: 10.1016/j.jpeds.2018.05.048. PubMed PMID: 30054165.
  18. Cizmeci MN, Kanburoglu MK, Akelma AZ, Ayyildiz A, Kutukoglu I, Malli DD, et al. Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case-control study from a tertiary care center in Turkey. Eur J Pediatr. 2015;174:809-15. doi: 10.1007/s00431-014-2469-1. PubMed PMID: 25504199.
  19. Leal YA, Alvarez-Nemegyei J, Velazquez JR, Rosado-Quiab U, Diego-Rodriguez N, Paz-Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC Pregnancy Childbirth. 2012;12:48. doi: 10.1186/1471-2393-12-48. PubMed PMID: 22691696; PubMed Central PMCID: PMCPMC3437209.
  20. Utomo MT. Risk factors of neonatal sepsis: a preliminary study in Dr. Soetomo hospital. Indonesian journal of tropical and infectious disease. 2010;1:23-6. doi: 10.20473/ijtid.v1i1.3718.
  21. Schrag SJ, Cutland CL, Zell ER, Kuwanda L, Buchmann EJ, Velaphi SC, et al. Risk factors for neonatal sepsis and perinatal death among infants enrolled in the prevention of perinatal sepsis trial, Soweto, South Africa. Pediatr Infect Dis J. 2012;31:821-6. doi: 10.1097/INF.0b013e31825c4b5a. PubMed PMID: 22565291.
  22. Schuchat A, Zywicki SS, Dinsmoor MJ, Mercer B, Romaguera J, O’Sullivan MJ, et al. Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics. 2000;105:21-6. doi: 10.1542/peds.105.1.21. PubMed PMID: 10617699.
  23. Gómez JL, González SC, Baldiris RM, Díaz-Pérez A, Perez I. Prognostic factors of early neonatal sepsis in the city of Cartagena Colombia. Global Journal of Health Science. 2018;10:1-30. doi: 10.5539/gjhs.v10n12p30.
  24. Kabwe M, Tembo J, Chilukutu L, Chilufya M, Ngulube F, Lukwesa C, et al. Etiology, Antibiotic Resistance and Risk Factors for Neonatal Sepsis in a Large Referral Center in Zambia. Pediatr Infect Dis J. 2016;35:e191-8. doi: 10.1097/INF.0000000000001154. PubMed PMID: 27031259.
  25. Verstraete EH, De Coen K, Vogelaers D, Blot S. Risk Factors for Health Care-Associated Sepsis in Critically Ill Neonates Stratified by Birth Weight. Pediatr Infect Dis J. 2015;34:1180-6. doi: 10.1097/INF.0000000000000851. PubMed PMID: 26244835.
  26. Boia M, Ilie C, Ioanăş L, Manea A, Iacob D, Cioboata D. Neonatal Septicemia–Retrospective Study on Premature Newborn. Revista Societăţii Române De Chirurgie Pediatrică. 2010;8:27.
  27. Babazono A, Kitajima H, Nishimaki S, Nakamura T, Shiga S, Hayakawa M, et al. Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS). Acta Med Okayama. 2008;62:261-8. doi: 10.18926/AMO/30938. PubMed PMID: 18766209.
  28. Dutta S, Reddy R, Sheikh S, Kalra J, Ray P, Narang A. Intrapartum antibiotics and risk factors for early onset sepsis. Arch Dis Child Fetal Neonatal Ed. 2010;95:F99-103. doi: 10.1136/adc.2009.163220. PubMed PMID: 19996327.
  29. Palatnik A, Liu LY, Lee A, Yee LM. Predictors of early-onset neonatal sepsis or death among newborns born at <32 weeks of gestation. J Perinatol. 2019;39:949-55. doi: 10.1038/s41372-019-0395-9. PubMed PMID: 31089257.
  30. Simarmata YBC, Harahap U, Djipta G. Identification of risk factors caused neonatal sepsis of prem ature neonatus in adam malik general hospital center. Birth. 2016;5:25.
  31. Mugalu J, Nakakeeto MK, Kiguli S, Kaddu-Mulindwa DH. Aetiology, risk factors and immediate outcome of bacteriologically confirmed neonatal septicaemia in Mulago hospital, Uganda. Afr Health Sci. 2006;6:120-6. doi: 10.5555/afhs.2006.6.2.120. PubMed PMID: 16916305; PubMed Central PMCID: PMCPMC1831983.
  32. Ogunlesi TA, Ogunfowora OB, Osinupebi O, Olanrewaju DM. Changing trends in newborn sepsis in Sagamu, Nigeria: bacterial aetiology, risk factors and antibiotic susceptibility. J Paediatr Child Health. 2011;47:5-11. doi: 10.1111/j.1440-1754.2010.01882.x. PubMed PMID: 20973858.
  33. Jiang Z, Ye GY. 1:4 matched case-control study on influential factor of early onset neonatal sepsis. Eur Rev Med Pharmacol Sci. 2013;17:2460-6. PubMed PMID: 24089224.
  34. Kawagoe JY, Segre CA, Pereira CR, Cardoso MF, Silva CV, Fukushima JT. Risk factors for nosocomial infections in critically ill newborns: a 5-year prospective cohort study. Am J Infect Control. 2001;29:109-14. doi: 10.1067/mic.2001.114162. PubMed PMID: 11287879.
  35. Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011;128:e1155-63. doi: 10.1542/peds.2010-3464. PubMed PMID: 22025590; PubMed Central PMCID: PMCPMC3208962.
  36. Woldu MA, Guta M, Lenjisa J, Tegegne G, Tesafye G, Dinsa H. Assessment of the incidence of neonatal sepsis, its risk factors, antimicrobial use and clinical outcomes in Bishoftu General Hospital, Neonatal Intensive Care Unit, Debrezeit-Ethiopia Pediat Therapeut. Int J Contemp Pediatr. 2014;4:2161. doi: 10.5455/2349-3291.ijcp20141102.
  37. Masanja PP, Kibusi SM, Mkhoi ML. Predictors of Early Onset Neonatal Sepsis among Neonates in Dodoma, Tanzania: A Case Control Study. J Trop Pediatr. 2020;66:257-66. doi: 10.1093/tropej/fmz062. PubMed PMID: 31539064.
  38. Jabiri A, Wella HL, Semiono A, Saria A, Protas J. Prevalence and factors associated with neonatal sepsis among neonates in Temeke and Mwananyamala Hospitals in Dar es Salaam, Tanzania. Tanzania Journal of Health Research. 2016;18. doi: 10.4314/thrb.v18i4.4.
  39. Bayih WA, Ayalew MY, Chanie ES, Abate BB, Alemayehu SA, Belay DM, et al. The burden of neonatal sepsis and its association with antenatal urinary tract infection and intra-partum fever among admitted neonates in Ethiopia: A systematic review and meta-analysis. Heliyon. 2021;7:e06121. doi: 10.1016/j.heliyon.2021.e06121. PubMed PMID: 33644445; PubMed Central PMCID: PMCPMC7887389.
  40. Agnche Z, Yenus Yeshita H, Abdela Gonete K. Neonatal Sepsis and Its Associated Factors Among Neonates Admitted to Neonatal Intensive Care Units in Primary Hospitals in Central Gondar Zone, Northwest Ethiopia, 2019. Infect Drug Resist. 2020;13:3957-67. doi: 10.2147/IDR.S276678. PubMed PMID: 33177846; PubMed Central PMCID: PMCPMC7650015.
  41. López-Martínez F, Núñez-Valdez ER, Gomez JL, García-Díaz V. A neural network approach to predict early neonatal sepsis. Computers & Electrical Engineering. 2019;76:379-88. doi: 1016/j.compeleceng.2019.04.015.
  42. Cortese F, Scicchitano P, Gesualdo M, Filaninno A, De Giorgi E, Schettini F, et al. Early and Late Infections in Newborns: Where Do We Stand? A Review. Pediatr Neonatol. 2016;57:265-73. doi: 10.1016/j.pedneo.2015.09.007. PubMed PMID: 26750406.
  43. Belachew A, Tewabe T. Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: systematic review and meta-analysis. BMC Pediatr. 2020;20:55. doi: 10.1186/s12887-020-1949-x. PubMed PMID: 32020850; PubMed Central PMCID: PMCPMC7001294.
  44. Ornoy A, Ergaz Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res. 2017;109:311-23. doi: 10.1002/bdra.23588. PubMed PMID: 28398685.
  45. Murthy S, Godinho MA, Guddattu V, Lewis LES, Nair NS. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis. PLoS One. 2019;14:e0215683. doi: 10.1371/journal.pone.0215683. PubMed PMID: 31022223; PubMed Central PMCID: PMCPMC6483350.
  46. Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD. Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis. Obstet Gynecol. 2021;137:1007-22. doi: 10.1097/AOG.0000000000004377. PubMed PMID: 33957655; PubMed Central PMCID: PMCPMC8905581.
آمار
تعداد مشاهده مقاله: 2,334
تعداد دریافت فایل اصل مقاله: 1,954


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب