LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,113
تعداد مقالات10,208
تعداد مشاهده مقاله40,777,483
تعداد دریافت فایل اصل مقاله8,803,221
Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. (1401). Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review. سامانه مدیریت نشریات علمی, 48(2), 110-117. doi: 10.30476/ijms.2022.92793.2411
Reza Mahdavi; Elnaz Faramarzi; Zeinab Nikniaz; Fatemeh FarshiRadvar. "Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review". سامانه مدیریت نشریات علمی, 48, 2, 1401, 110-117. doi: 10.30476/ijms.2022.92793.2411
Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. (1401). 'Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review', سامانه مدیریت نشریات علمی, 48(2), pp. 110-117. doi: 10.30476/ijms.2022.92793.2411
Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review. سامانه مدیریت نشریات علمی, 1401; 48(2): 110-117. doi: 10.30476/ijms.2022.92793.2411

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review

Iranian Journal of Medical Sciences
مقاله 2، دوره 48، شماره 2، خرداد 2023، صفحه 110-117    اصل مقاله (309.42 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2022.92793.2411
نویسندگان
Reza Mahdavi1؛ Elnaz Faramarzi2؛ Zeinab Nikniaz2؛ Fatemeh FarshiRadvar* 3
1Department of Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Nutrition Research Centre of Tabriz University of Medical Sciences. Tabriz, Iran
چکیده
Background: Previous studies found that the use of probiotics may have a protective effect on chemotherapy-associated toxicity in cancer patients. A systematic review was conducted to evaluate the effect of probiotics and synbiotics on chemoradiotherapy-associated toxicity in colorectal cancer (CRC) patients.
Methods: A systematic review of randomized controlled trials (RCTs) was performed to assess the effect of probiotics and synbiotics in CRC patients undergoing chemotherapy. All RCTs in English, up to January 2021, were included through a literature search in Scopus, Google Scholar, PubMed (PMC Central, MEDLINE), ClinicalTrials.gov, and ProQuest databases. The impact of probiotics and synbiotics on the side effects associated with chemotherapy, radiotherapy, and chemoradiotherapy in CRC patients was evaluated. The quality of the RTCs was independently assessed by two reviewers. EndNote X8 software was used to manage the search results.
Results: Of the 904 identified articles, three studies finally met the inclusion criteria and were systematically reviewed. Two studies reported that patients who received probiotics had less abdominal discomfort and required less bowel toxicity-related hospital care. Although probiotic supplementation lowered radiation-associated diarrhea, it had no significant effect when anti-diarrheal drugs were used. Another study reported that synbiotic supplementation improved quality of life and marginally reduced diarrhea and serum levels of high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase (MMP-2 and MMP-9).
Conclusion: Probiotics and synbiotics do not have a significant effect on reducing chemotherapy-associated toxicity and diarrhea in CRC patients. These findings should be substantiated by further RCTs with rigorous placebo-controlled studies.
کلیدواژه‌ها
Probiotics؛ Synbiotic؛ Colorectal neoplasms؛ Systematic review
سایر فایل های مرتبط با مقاله
مراجع
  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394-424. doi: 10.3322/caac.21492. PubMed PMID: 30207593.
  2. Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley des Varannes S, et al. Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications. Aliment Pharmacol Ther. 2014;40:409-21. doi: 10.1111/apt.12878. PubMed PMID: 25040088.
  3. Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell. 2017;170:548-63. doi: 10.1016/j.cell.2017.07.008. PubMed PMID: 28753429; PubMed Central PMCID: PMCPMC5767127.
  4. Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, et al. Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans. Cell. 2017;169:442-56 e18. doi: 10.1016/j.cell.2017.03.040. PubMed PMID: 28431245; PubMed Central PMCID: PMCPMC5406385.
  5. Packey CD, Ciorba MA. Microbial influences on the small intestinal response to radiation injury. Curr Opin Gastroenterol. 2010;26:88-94. doi: 10.1097/MOG.0b013e3283361927. PubMed PMID: 20040865; PubMed Central PMCID: PMCPMC4063200.
  6. Crawford PA, Gordon JI. Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci U S A. 2005;102:13254-9. doi: 10.1073/pnas.0504830102. PubMed PMID: 16129828; PubMed Central PMCID: PMCPMC1193536.
  7. Zwielehner J, Lassl C, Hippe B, Pointner A, Switzeny OJ, Remely M, et al. Changes in human fecal microbiota due to chemotherapy analyzed by TaqMan-PCR, 454 sequencing and PCR-DGGE fingerprinting. PLoS One. 2011;6:e28654. doi: 10.1371/journal.pone.0028654. PubMed PMID: 22194876; PubMed Central PMCID: PMCPMC3237468.
  8. Stringer AM, Al-Dasooqi N, Bowen JM, Tan TH, Radzuan M, Logan RM, et al. Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases. Support Care Cancer. 2013;21:1843-52. doi: 10.1007/s00520-013-1741-7. PubMed PMID: 23397098.
  9. Osterlund P, Ruotsalainen T, Korpela R, Saxelin M, Ollus A, Valta P, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer. 2007;97:1028-34. doi: 10.1038/sj.bjc.6603990. PubMed PMID: 17895895; PubMed Central PMCID: PMCPMC2360429.
  10. Delia P, Sansotta G, Donato V, Frosina P, Messina G, De Renzis C, et al. Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol. 2007;13:912-5. doi: 10.3748/wjg.v13.i6.912. PubMed PMID: 17352022; PubMed Central PMCID: PMCPMC4065928.
  11. Timko J. Probiotics as prevention of radiation-induced diarrhoea. Journal of Radiotherapy in Practice. 2010;9:201-8. doi: 10.1017/S1460396910000087.
  12. Mego M, Chovanec J, Vochyanova-Andrezalova I, Konkolovsky P, Mikulova M, Reckova M, et al. Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study. Complement Ther Med. 2015;23:356-62. doi: 10.1016/j.ctim.2015.03.008. PubMed PMID: 26051570.
  13. Tonneau M, Elkrief A, Pasquier D, Paz Del Socorro T, Chamaillard M, Bahig H, et al. The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: A systematic review. Radiother Oncol. 2021;156:1-9. doi: 10.1016/j.radonc.2020.10.033. PubMed PMID: 33137398.
  14. Liu MM, Li ST, Shu Y, Zhan HQ. Probiotics for prevention of radiation-induced diarrhea: A meta-analysis of randomized controlled trials. PLoS One. 2017;12:e0178870. doi: 10.1371/journal.pone.0178870. PubMed PMID: 28575095; PubMed Central PMCID: PMCPMC5456391.
  15. Devaraj NK, Suppiah S, Veettil SK, Ching SM, Lee KW, Menon RK, et al. The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. Nutrients. 2019;11. doi: 10.3390/nu11122886. PubMed PMID: 31783578; PubMed Central PMCID: PMCPMC6950027.
  16. Lytvyn L, Quach K, Banfield L, Johnston BC, Mertz D. Probiotics and synbiotics for the prevention of postoperative infections following abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. J Hosp Infect. 2016;92:130-9. doi: 10.1016/j.jhin.2015.08.028. PubMed PMID: 26601607.
  17. Liu PC, Yan YK, Ma YJ, Wang XW, Geng J, Wang MC, et al. Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis. Gastroenterol Res Pract. 2017;2017:6029075. doi: 10.1155/2017/6029075. PubMed PMID: 28484489; PubMed Central PMCID: PMCPMC5397731.
  18. Skonieczna-Zydecka K, Kaczmarczyk M, Loniewski I, Lara LF, Koulaouzidis A, Misera A, et al. A Systematic Review, Meta-Analysis, and Meta-Regression Evaluating the Efficacy and Mechanisms of Action of Probiotics and Synbiotics in the Prevention of Surgical Site Infections and Surgery-Related Complications. J Clin Med. 2018;7. doi: 10.3390/jcm7120556. PubMed PMID: 30558358; PubMed Central PMCID: PMCPMC6307089.
  19. Lu D, Yan J, Liu F, Ding P, Chen B, Lu Y, et al. Probiotics in preventing and treating chemotherapy-induced diarrhea: a meta-analysis. Asia Pac J Clin Nutr. 2019;28:701-10. doi: 10.6133/apjcn.201912_28(4).0005. PubMed PMID: 31826366.
  20. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71. PubMed PMID: 33782057; PubMed Central PMCID: PMCPMC8005924.
  21. Higgins J. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. 2011.
  22. Farshi Radvar F, Mohammad-Zadeh M, Mahdavi R, Andersen V, Nasirimotlagh B, Faramarzi E, et al. Effect of synbiotic supplementation on matrix metalloproteinase enzymes, quality of life and dietary intake and weight changes in rectal cancer patients undergoing neoadjuvant chemoradiotherapy. Mediterranean Journal of Nutrition and Metabolism. 2020;13:225-35. doi: 10.3233/MNM-200413.
  23. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731-40. doi: 10.1056/NEJMoa040694. PubMed PMID: 15496622.
  24. Bentzen AG, Balteskard L, Wanderas EH, Frykholm G, Wilsgaard T, Dahl O, et al. Impaired health-related quality of life after chemoradiotherapy for anal cancer: late effects in a national cohort of 128 survivors. Acta Oncol. 2013;52:736-44. doi: 10.3109/0284186X.2013.770599. PubMed PMID: 23438358.
  25. Wong SH, Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 2019;16:690-704. doi: 10.1038/s41575-019-0209-8. PubMed PMID: 31554963.
  26. Wang YH, Yao N, Wei KK, Jiang L, Hanif S, Wang ZX, et al. The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: a systematic review and meta-analysis. Eur J Clin Nutr. 2016;70:1246-53. doi: 10.1038/ejcn.2016.102. PubMed PMID: 27329608.
  27. Lin S, Shen Y. The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: A systematic review and meta-analysis based on 23 randomized studies. Int J Surg. 2020;84:69-77. doi: 10.1016/j.ijsu.2020.10.012. PubMed PMID: 33080416.
  28. Redman MG, Ward EJ, Phillips RS. The efficacy and safety of probiotics in people with cancer: a systematic review. Ann Oncol. 2014;25:1919-29. doi: 10.1093/annonc/mdu106. PubMed PMID: 24618152.
آمار
تعداد مشاهده مقاله: 1,604
تعداد دریافت فایل اصل مقاله: 1,869


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب