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Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. (1401). Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review. سامانه مدیریت نشریات علمی, 48(2), 110-117. doi: 10.30476/ijms.2022.92793.2411
Reza Mahdavi; Elnaz Faramarzi; Zeinab Nikniaz; Fatemeh FarshiRadvar. "Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review". سامانه مدیریت نشریات علمی, 48, 2, 1401, 110-117. doi: 10.30476/ijms.2022.92793.2411
Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. (1401). 'Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review', سامانه مدیریت نشریات علمی, 48(2), pp. 110-117. doi: 10.30476/ijms.2022.92793.2411
Mahdavi, Reza, Faramarzi, Elnaz, Nikniaz, Zeinab, FarshiRadvar, Fatemeh. Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review. سامانه مدیریت نشریات علمی, 1401; 48(2): 110-117. doi: 10.30476/ijms.2022.92793.2411

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review

Iranian Journal of Medical Sciences
مقاله 2، دوره 48، شماره 2، خرداد 2023، صفحه 110-117    اصل مقاله (309.42 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2022.92793.2411
نویسندگان
Reza Mahdavi1؛ Elnaz Faramarzi2؛ Zeinab Nikniaz2؛ Fatemeh FarshiRadvar* 3
1Department of Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Nutrition Research Centre of Tabriz University of Medical Sciences. Tabriz, Iran
چکیده
Background: Previous studies found that the use of probiotics may have a protective effect on chemotherapy-associated toxicity in cancer patients. A systematic review was conducted to evaluate the effect of probiotics and synbiotics on chemoradiotherapy-associated toxicity in colorectal cancer (CRC) patients.
Methods: A systematic review of randomized controlled trials (RCTs) was performed to assess the effect of probiotics and synbiotics in CRC patients undergoing chemotherapy. All RCTs in English, up to January 2021, were included through a literature search in Scopus, Google Scholar, PubMed (PMC Central, MEDLINE), ClinicalTrials.gov, and ProQuest databases. The impact of probiotics and synbiotics on the side effects associated with chemotherapy, radiotherapy, and chemoradiotherapy in CRC patients was evaluated. The quality of the RTCs was independently assessed by two reviewers. EndNote X8 software was used to manage the search results.
Results: Of the 904 identified articles, three studies finally met the inclusion criteria and were systematically reviewed. Two studies reported that patients who received probiotics had less abdominal discomfort and required less bowel toxicity-related hospital care. Although probiotic supplementation lowered radiation-associated diarrhea, it had no significant effect when anti-diarrheal drugs were used. Another study reported that synbiotic supplementation improved quality of life and marginally reduced diarrhea and serum levels of high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase (MMP-2 and MMP-9).
Conclusion: Probiotics and synbiotics do not have a significant effect on reducing chemotherapy-associated toxicity and diarrhea in CRC patients. These findings should be substantiated by further RCTs with rigorous placebo-controlled studies.
کلیدواژه‌ها
Probiotics؛ Synbiotic؛ Colorectal neoplasms؛ Systematic review
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