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Salehzadeh, Farhad, Pourfarzi, Farhad, Molatefi, Rasool, Davarnia, Behzad, Shahbazfar, Ehsan, Ahmadabadi, Farzad. (1401). Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 48(1), 43-48. doi: 10.30476/ijms.2022.92802.2408
Farhad Salehzadeh; Farhad Pourfarzi; Rasool Molatefi; Behzad Davarnia; Ehsan Shahbazfar; Farzad Ahmadabadi. "Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study". سامانه مدیریت نشریات علمی, 48, 1, 1401, 43-48. doi: 10.30476/ijms.2022.92802.2408
Salehzadeh, Farhad, Pourfarzi, Farhad, Molatefi, Rasool, Davarnia, Behzad, Shahbazfar, Ehsan, Ahmadabadi, Farzad. (1401). 'Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study', سامانه مدیریت نشریات علمی, 48(1), pp. 43-48. doi: 10.30476/ijms.2022.92802.2408
Salehzadeh, Farhad, Pourfarzi, Farhad, Molatefi, Rasool, Davarnia, Behzad, Shahbazfar, Ehsan, Ahmadabadi, Farzad. Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 1401; 48(1): 43-48. doi: 10.30476/ijms.2022.92802.2408

Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study

Iranian Journal of Medical Sciences
مقاله 6، دوره 48، شماره 1، فروردین 2023، صفحه 43-48    اصل مقاله (252.09 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.92802.2408
نویسندگان
Farhad Salehzadeh1؛ Farhad Pourfarzi2؛ Rasool Molatefi1؛ Behzad Davarnia3؛ Ehsan Shahbazfar1؛ Farzad Ahmadabadi* 1
1Department of Pediatric, Bouali Children’s Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
2Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3Department of Genetic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
چکیده
Background: In December 2019, an outbreak of pneumonia caused by the novel coronavirus disease 2019 (COVID-19) became a pandemic and caused a global health crisis. This study evaluates the immunogenic potential of the Mediterranean fever (MEFV) gene in patients with COVID-19. 
Methods: A cross-sectional study was conducted from March to April 2020 in various COVID-19 referral centers in Ardabil, Iran. Blood samples of 50 hospitalized patients with confirmed COVID-19 were evaluated for MEFV gene mutation using the amplification refractory mutation system polymerase chain reaction (ARMS-PCR) and Sanger sequencing. Statistical analysis was performed using SPSS software, version 22.0.
Results: Mutations of the MEFV gene were found in 6 (12%) of the patients. All mutations were heterozygous, and no homozygous or compound heterozygous forms were detected. The total mutant allele frequency was 6% and the carrier rate was 12%. The most common allele of the MEFV variant was E148Q, detected in 3 (6%) patients. No mutant variant of the MEFV gene was detected in deceased patients. None of the mutation carriers had familial Mediterranean fever (FMF) symptoms or a family history of FMF.
Conclusion: MEFV gene mutations may have immunogenic potential in patients with COVID-19.
A preprint version of this article has already been published at https://www.researchsquare.com/article/rs-69373/latest.pdf.
کلیدواژه‌ها
COVID-19؛ Familial Mediterranean fever؛ MEFV gene
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