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Niknezhad, Seyyed Vahid, Ghasemi, Younes, Khalili Gashtroudkhani, Ali, Mohammadi, Hamidreza, Heidari, Reza. (1401). The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction. سامانه مدیریت نشریات علمی, 8(4), 211-222. doi: 10.30476/tips.2022.95246.1143
Seyyed Vahid Niknezhad; Younes Ghasemi; Ali Khalili Gashtroudkhani; Hamidreza Mohammadi; Reza Heidari. "The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction". سامانه مدیریت نشریات علمی, 8, 4, 1401, 211-222. doi: 10.30476/tips.2022.95246.1143
Niknezhad, Seyyed Vahid, Ghasemi, Younes, Khalili Gashtroudkhani, Ali, Mohammadi, Hamidreza, Heidari, Reza. (1401). 'The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction', سامانه مدیریت نشریات علمی, 8(4), pp. 211-222. doi: 10.30476/tips.2022.95246.1143
Niknezhad, Seyyed Vahid, Ghasemi, Younes, Khalili Gashtroudkhani, Ali, Mohammadi, Hamidreza, Heidari, Reza. The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction. سامانه مدیریت نشریات علمی, 1401; 8(4): 211-222. doi: 10.30476/tips.2022.95246.1143

The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction

Trends in Pharmaceutical Sciences
مقاله 1، دوره 8، شماره 4، اسفند 2022، صفحه 211-222    اصل مقاله (688.88 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.95246.1143
نویسندگان
Seyyed Vahid Niknezhad1؛ Younes Ghasemi2، 3؛ Ali Khalili Gashtroudkhani4؛ Hamidreza Mohammadi5؛ Reza Heidari* 2
1Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Polymer Engineering, Faculty of Engineering, Qom University of Technology, Qom, Iran.
5Department of Pharmacology and Toxicology, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
چکیده
Liver injury is a severe clinical complication associated with various diseases or xenobiotics exposure. Hence, finding safe and clinically applicable hepatoprotective agents have great value. Several naturally-derived chemicals have gotten attention for their biological functions. Polysaccharides are bioactive and safe chemicals produced by a variety of microorganisms. Several exciting features, including radical scavenging and antioxidative properties, have been attributed to polysaccharides. Recently we found that the exopolysaccharide derived from Pentoea sp. BCCS 001 GH (Pentoan exopolysaccharide; PEPS) revealed significant antioxidant and radical scavenging properties in an in vitro model. Hence, the current study was designed to evaluate the in vivo hepatoprotective effects of PEPS. Bile duct ligated (BDL) rats received PEPS (0.05 and 0.1% w: v in drinking water), and serum biomarkers of liver injury, liver tissue histopathological alterations, and hepatic markers of oxidative stress were monitored. Severely elevated serum biomarkers of liver injury and histopathological changes, including inflammatory cell infiltration, necrosis, bile duct proliferation, and tissue fibrosis, were evident in BDL animals. Moreover, a significant amount of reactive oxygen species, increased level of lipid peroxidation, and defects in tissue antioxidant capacity were apparent in BDL rats. It was found that PEPS significantly improved liver function, blunted hepatic pathological changes, and counteracted oxidative stress in the liver tissue. The radical scavenging and antioxidant properties of PEPS seem to play a fundamental role in its hepatoprotective properties.
 
Please cite this article as: Seyyed Vahid Niknezhad, Younes Ghasemi, Ali Khalili Gashtroudkhani, Hamidreza Mohammadi, Reza Heidari. The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction. Trends in Pharmaceutical Sciences. 2022;8(4):211-222. doi: 10.30476/tips.2022.95246.1143
کلیدواژه‌ها
Bile acid؛ Cholestasis؛ Fibrosis؛ Hepatoprotection؛ Oxidative stress
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