پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,149 |
| تعداد مقالات | 10,518 |
| تعداد مشاهده مقاله | 45,415,483 |
| تعداد دریافت فایل اصل مقاله | 11,291,258 |
Rosuvastatin Intervention Decreased the Frequencies of the TIM-3+ Population of NK Cells and NKT Cells among Patients with Chronic Hepatitis B | ||
| Iranian Journal of Immunology | ||
| دوره 19، شماره 3، آذر 2022، صفحه 255-262 اصل مقاله (2.26 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2022.93726.2250 | ||
| نویسندگان | ||
| Alireza Norouzi1، 2؛ Shohreh Taziki* 1، 3؛ Ali Najafipasandi1، 2؛ Saeed Mohammadi4، 5؛ Gholamreza Roshandel1 | ||
| 1Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 2Department of Internal Medicine, Sayyad-e-Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 3Department of Pharmacology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 4Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 5Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran | ||
| چکیده | ||
| Background: Natural killer (NK) cells are dichotomously involved in chronic hepatitis B (CHB) infection as principal members of innate immunity. An effective treatment should enhance the antiviral potentials of NK cells and not their immunomodulatory roles. TIM-3 (T-cell immunoglobulin and mucin-containing domain) is a molecule with an essential role in controlling immune tolerance. TIM-3 demonstrated the highest expression among NK cells of patients with chronic liver disorders. Statins have been reported to attenuate the levels of TIM-3 on NK cells. Objectives: To investigate the frequencies of NK cells, NKT cells, and TIM-3+ population in patients with CHB upon rosuvastatin (RSV) intervention. Methods: Thirty confirmed patients with CHB were randomly assigned into two groups of 15 (receiving 20 mg of RSV or placebo per day) for 12 weeks. We evaluated the percentages of TIM-3+ cells by staining the peripheral blood mononuclear cells (PBMCs) with CD3, CD16, and CD56 markers using flow cytometry. Results: Our findings indicated that RSV administration could increase CD3- CD56+ NK cells (P>0.05) and CD3+ CD16+ CD56+ NKT cells (P<0.05). RSV intervention could reduce the percentages of TIM-3+ cells among NK cells (P<0.01) and NKT cells (P> 0.05) of patients with CHB compared with the placebo group. Conclusions: The increased population of NK and NKT cells and the effective reduction of TIM-3+ cells among patients with CHB delineated that rosuvastatin could be proposed as an appropriate modulator of innate immune response (regarding NK and NKT cells) in favor of enhancing their antiviral activities. | ||
| کلیدواژه‌ها | ||
| HBV؛ NK cells؛ NKT cells؛ Rosuvastatin؛ TIM-3 | ||
|
آمار تعداد مشاهده مقاله: 1,449 تعداد دریافت فایل اصل مقاله: 978 |
||