|تعداد مشاهده مقاله||10,670,313|
|تعداد دریافت فایل اصل مقاله||5,133,255|
Comparison of Serum Hormone Levels in Pilonidal Sinus Disease Patients by Gender
|Iranian Journal of Colorectal Research|
|مقاله 2، دوره 10، شماره 3، آذر 2022، صفحه 87-91 اصل مقاله (465.17 K)|
|نوع مقاله: Research/Original Article|
|شناسه دیجیتال (DOI): 10.30476/acrr.2022.96599.1152|
|Farzaneh Nazari 1؛ Zahra Parsaiyan 2؛ Leyla Rezaei3؛ Mahshid Mohammadpour4؛ Kamran Mirzaei5|
|1Department of Obstetrics and Gynecology, perinatology unit. Boushehr university of medical sciences, Boushehr, Iran|
|2Department of Obstetrics and Gynecology. Deylam baqiyatallah hospital, Boushehr, Iran|
|3Department of general surgery, Boushehr university of medical sciences, Boushehr, Iran|
|4Department of Obstetrics and Gynecology, Boushehr university of medical sciences, Boushehr, Iran|
|5Community Medicine department, Boushehr University of Medical Sciences, Boushehr, Iran|
|Background: Pilonidal sinus disease (PSD) describes an inflammation of the subcutaneous fatty tissue causing a pilonidal sinus which can lead to pus collection and tenderness. The study objective was to investigate the relationship between serum hormones, PSD and associated factors in patients referring to Khalij Fars hospital in Bushehr city, Iran in 2017. |
Methods: A cross-sectional study consisted of 50 patients with pilonidal sinus disease who underwent surgery in Khalij Fars hospital in Bushehr city, Iran between February and May 2017 was conducted. The patients with SPD who consented to participate in the study were enrolled in the research and subjected to review their physical signs and medical history. Hormone levels (including the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, dehydroepiandrosterone (DHEA), and prolactin) were measured.
Results: The level of sex hormones in female patients was significantly higher in comparison with males except for testosterone (3.9±1.73 in male; 0.35±0.17 in females). The frequency of patients with normal serum levels of LH, testosterone, and prolactin was higher in females than those in the male group, whereas the rate of those with normal levels of FSH, DHEAS, and Prolactin in male patient group was higher, compared with the female group (P<0.05).
Conclusion: As there are a few studies conducted on hormonal status of patients with pilonidal sinus by genders, we conducted the current study, to compare serum levels between male and female patients. Raised serum prolactin, LH, and testosterone levels in women might be contributed to increasing androgen levels and causing excessive hair growth/ hirsutism.
|Pilonidal sinus disease؛ pilonidal sinus؛ gender؛ age؛ sex hormones؛ BMI|
1. Doll, D. et al. Strength of occipital
hair as an explanation for pilonidal
sinus disease caused by intruding hair.
DCR 60, 979–986
2. Altintoprak F, Gundogdu K, Ergonenc
T, Dikicier E, Cakmak G, Celebi F.
Retrospective review of pilonidal
sinus patients with early discharge
after Limberg flap procedure. Int Surg
3. Page, B. H. The entry of hair into a
pilonidal sinus. Br. J. Surg 1969; 56,
4. Chintapalta S, Safarani N, Kumar S,
Haboubi N. Sacrococcygeal pilonidal
sinus: historical review, pathological
insight and surgical options. Tech
Coloproctol 2003; 7: 3– 8.
5. Nasr A, Sigmund HE. A pediatric
surgeon’s 35-year experience with
pilonidal disease in a Canadian
children’s hospital. Can J Surg 2011;
6. Özkan Z, Aksoy N, Emir S.,
Kanat B. H., Gönen A. N., Yazar
F. M., et al. Investigation of the
relationship between serum hormones
and pilonidal sinus disease: a
cross-sectional study Colorectal
Disease 2014; 16(4): 311-314.
7. Jones DJ. ABC of colorectal diseases.
Pilonidal sinus. BMJ 1992; 305:
8. Mortimer PS, Dawber RPR, Gales
MA, Moore RA. Mediation of
hidradenitis suppurativa androgens.
Br Med J (Clin Res Ed) 1986; 292:
9. Rosenfield RL. Clinical practice.
Hirsutism. N Engl J Med 2005; 353:
10. Seppala M, Hirnoven E. Raised serum
prolactin levels with hirsutism and
amenorrhoea. Br Med J 1975; 4:
11. National Health System. What is the
body mass index (BMI)? available at
https://www.nhs.uk/common-healthquestions/lifestyle/what-is-the-bodymass-index-bmi/, accessed in August
12. Test ID: TTFB-testosterone, total,
bioavailable, and free, serum.
13. University of Rochester Medical
Center, Health Encyclopedia.
Luteinizing Hormone (Blood),
available at https://www.urmc.
14. Lobo RA. Infertility: etiology,
diagnostic evaluation, management,
prognosis. In: Lobo RA, Gershenson
DM, Lentz GM, Valea FA, eds.
Comprehensive Gynecology. 7th
ed. Philadelphia, PA: Elsevier; 2017:
15. Maleki A, Rashidi N, Aghaei Meybodi
H, Montazeri M, Montazeri M, Falsafi
F, et al. Metabolic syndrome and
inflammatory biomarkers in adults:
A population-based survey in western
region of Iran. Int Cardiovasc Res J.
16. Kaymakcioglu N, Yagci G., Simsek
A., Unlu A., Tekin O.F., Cetiner S.,
et al. Treatment of pilonidal sinus
by phenol application and factors
affecting the recurrence, Tech.
Coloproctol. 9 (1) (2005) 21–24.
17. Arda I.S., Güney L.H., Sevmiş Ş, Hiçsönmez A. High body mass index
as a possible risk factor for pilonidal
sinus disease in adolescents, World J.
Surg. 2005; 29 (4): 469–471.
18. Cubukcu A, Gonullu NN, Paksoy M,
Alponat A, Kuru M, O¨zbay O. The
role of obesity on the recurrence of
pilonidal sinus disease in patients,
who were treated by excision and
Limberg flap transposition. Int J
Colorectal Dis 2000; 15(3):173–175
19. Akinci OF, Bozer M, Uzunkoy A,
Duzgun SA, Coşkun A. Incidence
and aetiological factors in pilonidal
sinus among Turkish soldiers. Eur J
Surg 1999; 165:339–42.
20. Bolandparvaz S, Moghadam Dizaj
P, Salahi R, Paydar S, Bananzadeh
M, Abbasi HR, et al. Evaluation of
the risk factors of pilonidal sinus:
a single center experience. Turk J
21. Serour F, Somekh E, Krutman B, et
al. Excision with primary closure and
suction drainage for pilonidal sinus in
adolescent patients. Pediatr. Surg. Int.
22. Baskom JU. Pilonidal disease: longterm results of follicle removal. Dis,
Colon Rectum 1983;26:800–807
23. Karydakis GE. Easy and successful
treatment of pilonidal sinus after
explanation of its causative process.
Aust. N. Z. J. Surg. 1992; 62:285–289
24. Patey D., Scarff R.W. Pathology of
postanal pilonidal sinus it’s bearing on
treatment, Lancet 1946; 248 (6423):
25. Doll, D. et al. Time and rate of sinus
formation in pilonidal sinus disease.
Int. J. Colorectal Dis. 23, 359–364
26. Ardelt, M. et al. Puberty is a major
factor in pilonidal sinus disease:
Gender-specific investigations of
case number development in Germany
from 2007 until 2015. Chirurg 88,
27. Yildiz t, Elmas B, Yucak A, Turgut
H.T., Ilce Z. Risk factors for pilonidal
sinus disease in teenagers, Indian J.
Pediatr. 2017; 84 (2): 134–138.
28. Fitzpatrick TB. The validity and
practicality of sun-reactive skin types
I through VI. Arch Dermatol. 1988;
29. Aldean I, Shankar PJ, Mathew J,
Safarani N, Haboubi NY. Simple
excision and primary closure of
pilonidal sinus: a simple modification
of conventional technique with
excellent results. Colorectal Dis
30. Levinson T, Sela T, Chencinski S,
Derazne E, Tzur D, Elad H, et al.
Pilonidal Sinus Disease: A 10-Year
Review Reveals Occupational Risk
Factors and the Superiority of the
Minimal Surgery Trephine Technique.
Mil Med. 2016; 181(4):389-94.
31. Faraj FH, Baba HO, Salih AM,
kakamad FH. Risk factors of pilonidal
sinus disease in preparatory school
students; a case control study. Ann
Med Surg. 2020; 57:46-48.
32. ML Price WAD Griffiths (1985)
ArticleTitleNormal body hair: a
review Clin. Exp. Dermatol 10 87–97
33. Comaish JS. The thyroid and hair
growth. Semin Dermatol 1985; 4:
34. Blok GJ, de Boer LJ, van der Veen
EA. Growth Hormone substitution in
adult growth hormone-deficient men
augments androgen effects on the
skin. Clin Endocrinol 1997; 47: 29–36.
35. Azziz R, Carmina E, Sawaya ME.
Idiopathic hirsutism. Endocr Rev
2000; 21: 347–62.
36. Rook/Wilkinson, Textbook of
Dermatology, 5th edition 1992,
Blackwell scientific publication,
37. Lunniss PJ, Jenkins PJ, Besser GM,
Perry LA, Phillips RK. Gender
differences in incidens of fistula-inano are not explained by circulating
sex hormones. Int J Colorectal Dis
1995; 10: 25–8.
تعداد مشاهده مقاله: 110
تعداد دریافت فایل اصل مقاله: 115