LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات9,995
تعداد مشاهده مقاله26,439,070
تعداد دریافت فایل اصل مقاله7,285,940
Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. (1401). Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 23(4), 472-479. doi: 10.30476/dentjods.2021.91479.1588
Yêda Maria Parro; Danielly de Mendonça Guimarães; Herick Sampaio Muller; Eduardo Barbosa Coelho; Andresa Aparecida Berretta; Jessica Aparecida de Lima; David De Jong; Vicente de Paulo Martins; Erica Negrini Lia. "Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 23, 4, 1401, 472-479. doi: 10.30476/dentjods.2021.91479.1588
Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. (1401). 'Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 23(4), pp. 472-479. doi: 10.30476/dentjods.2021.91479.1588
Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1401; 23(4): 472-479. doi: 10.30476/dentjods.2021.91479.1588

Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial

Journal of Dentistry
مقاله 7، دوره 23، شماره 4 - شماره پیاپی 77، اسفند 2022، صفحه 472-479    اصل مقاله (339.43 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2021.91479.1588
نویسندگان
Yêda Maria Parro1؛ Danielly de Mendonça Guimarães2؛ Herick Sampaio Muller3؛ Eduardo Barbosa Coelho4؛ Andresa Aparecida Berretta5؛ Jessica Aparecida de Lima5؛ David De Jong6؛ Vicente de Paulo Martins7؛ Erica Negrini Lia* 8
1Tropical Medicine Post-Graduate Program, School of Medicine, University of Brasília, Brasília, DF, Brazil.
2Dental Student, Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
3Molecular Biology Post-Graduate Program, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
4Dept. of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
5Apis Flora Industrial e Comercial Ltda, Ribeirão Preto, SP, Brazil.
6Genetics Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
7Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
8Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
چکیده
Statement of the Problem: Natural products have attracted interest as an alternative to synthetic medications for the treatment of oral diseases due to their efficacy and safety. Propolis and pomegranate extracts have both demonstrated efficacy for the treatment of denture stomatitis. However, use of the two compounds together has not been tested for this purpose.
Purpose: A comparison was made of the efficacy of a commercially available propolis-pomegranate buccal spray formulation for the treatment of denture stomatitis, compared with miconazole gel, based on stomatitis lesions and Candida spp. concentrations in mouth rinses.
Materials and Method: This was an experimental study, characterized as an open-label, parallel two-armed, non-inferiority randomized clinical trial. Forty elderly adults aged ≥ 60 years with denture stomatitis were randomly allocated to two groups. The patients applied a buccal spray containing 0.5% propolis and 0.9% pomegranate extracts or 2% miconazole gel, a standard treatment recommended in Brazil, to the inner surface of their dentures three times a day for 14 days. They were examined at days 1, 7, 14 and stomatitis lesions were categorized according to Newton’s score. Mouth rinses were made with saline solution at days 1 and 14 and then assessed for Candida spp.
Results: Both treatments reduced the Newton’s score, with clinical cure rates of 75 and 40% for the miconazole and propolis-pomegranate groups, respectively. The Candida concentrations in the mouth rinse decreased significantly only in the miconazole group.
Conclusion: The propolis-pomegranate spray was less effective than the miconazole treatment. However, clinical improvement was also observed in patients treated with the propolis-pomegranate buccal spray.
کلیدواژه‌ها
Lythraceae؛ Denture stomatitis؛ Propolis؛ Clinical trial
سایر فایل های مرتبط با مقاله
مراجع
  • Hoare A, Marsh PD, Diaz PI. Ecological therapeutic opportunities for oral diseases. Microbiol Spectr. 2017; 5: 10.1128.
  • Hellstein JW, Marek CL. Candidiasis: Red and White Manifestations in the Oral Cavity. Head Neck Pathol. 2019; 13: 25–32.
  • Quindós G, Gil-Alonso S, Marcos-Arias C, Sevillano E, Mateo E, Jauregizar N, et al. Therapeutic tools for oral candidiasis: Current and new antifungal drugs. Med Oral Patol Oral Cir Bucal. 2019; 24: e172–e180.
  • Cannon RD, Holmes AR. Learning the ABC of oral fungal drug resistance. Mol Oral Microbiol. 2015; 30: 425-437.
  • Rodrigues MC, Oliveira CD. Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review. Rev Lat Am Enfermagem. 2016; 24: e2800.
  • Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, et al. Natural products for drug discovery in the 21st century: innovations for novel drug discovery. Int J Mol Sci. 2018;19: 1578.
  • Nani BD, Sardi J, Lazarini JG, Silva DR, Massariolli AP, Cunha TM, et al. Anti-inflammatory and anti-CandidaEffects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food. J Agric Food Chem. 2020; 68: 2861–2871.
  • De*Barros MP, Sousa JP, Bastos JK, de*Andrade SF. Effect of Brazilian green propolis on experimental gastriculcers in rats. J Ethnopharmacol. 2007; 110: 567-571.
  • De*Luca MP, Franca JR, Macedo FA, Grenho L, Cortes ME, Faraco AA, et al. Propolis varnish: antimicrobial properties against cariogenic bacteria, cytotoxicity and sustained-release profile. Biomed Res Int. 2014; 2014: 348647.
  • Berretta AA, Nascimento AP, Bueno PC, Vaz MM, Marchetti JM. Propolis standardized extract (EPP-AF®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds. Int J Biol Sci. 2012; 8: 512–521.
  • Simões LM, Gregório LE, da*Silva*Filho AA, de*Souza ML, Azzolini AE, Bastos JK, et al. Effect of Brazilian green propolis on the production of reactive oxygen species by stimulated neutrophils. J Ethnopharmacol. 2004; 94: 59–65.
  • Berretta AA, de*Castro PA, Cavalheiro AH, Fortes VS, Bom VP, Nascimento AP, et al. Evaluation of Mucoadhesive Gels with Propolis (EPP-AF®) in Preclinical Treatment of Candidiasis Vulvovaginal Infection. J Evid Based Complementary Altern Med. 2013: 2013: 641480.
  • De*Castro PA, Bom VL, Brown NA, de*Almeida RS, Ramalho LN, Savoldi M, et al. Identification of the cell targets important for propolis-induced cell death in Candida albicans. Fungal Genet Biol. 2013; 60: 74–86.
  • Pina GM, Lia EN, Berretta AA, Nascimento AP, Torres EC, Buszinski AF, et al. Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. Evid Based Complement Alternat Med. 2017; 2017: 8971746.
  • Capistrano HM, de*Assis EM, Leal RM, Alvarez-Leite ME, Brener S, Bastos EM. Brazilian green propolis compared to miconazole gel in the treatment of Candida-associated denture stomatitis. J Evid Based Complementary Altern Med. 2013; 2013: 947980.
  • Santos VR, Pimenta FJ, Aguiar MC, do*Carmo MA, Naves MD, Mesquita RA. Oral candidiasis treatment with Brazilian ethanol propolis extract. Phytother Res. 2005; 1: 652–654.
  • Santos VR, Gomes RT, de*Mesquita RA, de*Moura MD, França EC, de*Aguiar E G, et al. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res. 2008; 22: 1544–1547.
  • Rocha, BA, Bueno PC, Vaz MM, Nascimento AP, Ferreira, NU, Moreno G, et al. Evaluation of a propolis water extract using a Reliable RP-HPLC methodology and in vitro and in vivo efficacy and safety characterization. Evid Based Complement Alternat Med. 2013; 2013: 670451.
  • Jurenka JS. Therapeutic applications of pomegranate (Punica granatum): a review. Altern Med Rev. 2008; 13: 128-144.
  • Endo EH, Cortez DA, Ueda-Nakamura T, Nakamura CV, Dias*Filho BP. Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans. Res Microbiol. 2010; 161: 534–540.
  • Millo G, Juntavee A, Ratanathongkam A, Nualkaew N, Peerapattana J, Chatchiwiwattana S. Antibacterial Inhibitory Effects of Punica granatumGel on Cariogenic Bacteria: An in vitro Int J Clin Pediatr Dent. 2017; 10: 152–157.
  • Jacob J, Lakshmanapermalsamy P, Illuri R, Bhosle D, Sangli GK, Mundkinajeddu D. In vitroEvaluation of Antioxidant Potential of Isolated Compounds and Various Extracts of Peel of Punica granatum Pharmacognosy Res. 2018; 10: 44-48.
  • Anibal PC, Peixoto IT, Foglio MA, Höfling JF. Antifungal activity of the ethanolic extracts of Punica granatum and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp. Braz J Microbiol. 2013; 44: 839–848.
  • Madugula P, Reddy S, Koneru J, Rao AS, Sruthi R, Dalli DT. "Rhetoric to Reality"- Efficacy of Punica granatum Peel Extract on Oral Candidiasis: An in vitroJ Clin Diagn Res. 2017; 11: ZC114–ZC117.
  • Almeida N, Saldanha LL, da*Silva RA, Pinke KH, da*Costa EF, Porto VC, et al. Antimicrobial activity of denture adhesive associated with Equisetum giganteum- and Punica granatum-enriched fractions against Candida albicans biofilms on acrylic resin surfaces. Biofouling. 2018; 34: 62–73.
  • Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses. 2003; 46: 192–196.
  • Newton AV. Denture sore mouth. A possible etiology. British Dent J. 1962; 112: 357-360.
  • Moskowitz HR. Utilitarian benefits of magnitude estimation scaling for testing product acceptability. In: Kuznicki JT, Johnson RA, Rutkiewic AF. Selected Sensory Methods: Problems and Approaches to Measuring Hedonics. 1th ed. West Conshocken, PA: ASTM International; 1982. p. 11.
  • Chow SC, Wang H, Shao J. Sample Size Calculations in Clinical Research. 2nd ed. New York: Chapman and Hall/CRC; p. 480.
  • Sforcin JM. Propolis and the immune system: a review. J Ethnopharmacol. 2007; 113: 1–14.
  • Cusinato D, Martinez EZ, Cintra M, Filgueira G, Berretta AA, Lanchote VL, et al. Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. J Ethnopharmacol. 2019; 245: 112174.
آمار
تعداد مشاهده مقاله: 876
تعداد دریافت فایل اصل مقاله: 761


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب