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Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. (1401). Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 23(4), 472-479. doi: 10.30476/dentjods.2021.91479.1588
Yêda Maria Parro; Danielly de Mendonça Guimarães; Herick Sampaio Muller; Eduardo Barbosa Coelho; Andresa Aparecida Berretta; Jessica Aparecida de Lima; David De Jong; Vicente de Paulo Martins; Erica Negrini Lia. "Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 23, 4, 1401, 472-479. doi: 10.30476/dentjods.2021.91479.1588
Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. (1401). 'Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 23(4), pp. 472-479. doi: 10.30476/dentjods.2021.91479.1588
Parro, Yêda, de Mendonça Guimarães, Danielly, Muller, Herick Sampaio, Coelho, Eduardo, Berretta, Andresa, Aparecida de Lima, Jessica, Jong, David, de Paulo Martins, Vicente, Lia, Erica. Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1401; 23(4): 472-479. doi: 10.30476/dentjods.2021.91479.1588

Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial

Journal of Dentistry
مقاله 7، دوره 23، شماره 4 - شماره پیاپی 77، اسفند 2022، صفحه 472-479    اصل مقاله (339.43 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2021.91479.1588
نویسندگان
Yêda Maria Parro1؛ Danielly de Mendonça Guimarães2؛ Herick Sampaio Muller3؛ Eduardo Barbosa Coelho4؛ Andresa Aparecida Berretta5؛ Jessica Aparecida de Lima5؛ David De Jong6؛ Vicente de Paulo Martins7؛ Erica Negrini Lia* 8
1Tropical Medicine Post-Graduate Program, School of Medicine, University of Brasília, Brasília, DF, Brazil.
2Dental Student, Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
3Molecular Biology Post-Graduate Program, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
4Dept. of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
5Apis Flora Industrial e Comercial Ltda, Ribeirão Preto, SP, Brazil.
6Genetics Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
7Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
8Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
چکیده
Statement of the Problem: Natural products have attracted interest as an alternative to synthetic medications for the treatment of oral diseases due to their efficacy and safety. Propolis and pomegranate extracts have both demonstrated efficacy for the treatment of denture stomatitis. However, use of the two compounds together has not been tested for this purpose.
Purpose: A comparison was made of the efficacy of a commercially available propolis-pomegranate buccal spray formulation for the treatment of denture stomatitis, compared with miconazole gel, based on stomatitis lesions and Candida spp. concentrations in mouth rinses.
Materials and Method: This was an experimental study, characterized as an open-label, parallel two-armed, non-inferiority randomized clinical trial. Forty elderly adults aged ≥ 60 years with denture stomatitis were randomly allocated to two groups. The patients applied a buccal spray containing 0.5% propolis and 0.9% pomegranate extracts or 2% miconazole gel, a standard treatment recommended in Brazil, to the inner surface of their dentures three times a day for 14 days. They were examined at days 1, 7, 14 and stomatitis lesions were categorized according to Newton’s score. Mouth rinses were made with saline solution at days 1 and 14 and then assessed for Candida spp.
Results: Both treatments reduced the Newton’s score, with clinical cure rates of 75 and 40% for the miconazole and propolis-pomegranate groups, respectively. The Candida concentrations in the mouth rinse decreased significantly only in the miconazole group.
Conclusion: The propolis-pomegranate spray was less effective than the miconazole treatment. However, clinical improvement was also observed in patients treated with the propolis-pomegranate buccal spray.
کلیدواژه‌ها
Lythraceae؛ Denture stomatitis؛ Propolis؛ Clinical trial
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