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Pouya, Sepideh, Kazemi, Maryam, Pouya, Setareh, Dehshahri, Ali, Sobhani, Zahra. (1401). Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery. سامانه مدیریت نشریات علمی, 8(3), 147-154. doi: 10.30476/tips.2022.95505.1146
Sepideh Pouya; Maryam Kazemi; Setareh Pouya; Ali Dehshahri; Zahra Sobhani. "Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery". سامانه مدیریت نشریات علمی, 8, 3, 1401, 147-154. doi: 10.30476/tips.2022.95505.1146
Pouya, Sepideh, Kazemi, Maryam, Pouya, Setareh, Dehshahri, Ali, Sobhani, Zahra. (1401). 'Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery', سامانه مدیریت نشریات علمی, 8(3), pp. 147-154. doi: 10.30476/tips.2022.95505.1146
Pouya, Sepideh, Kazemi, Maryam, Pouya, Setareh, Dehshahri, Ali, Sobhani, Zahra. Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery. سامانه مدیریت نشریات علمی, 1401; 8(3): 147-154. doi: 10.30476/tips.2022.95505.1146

Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery

Trends in Pharmaceutical Sciences
مقاله 3، دوره 8، شماره 3، آذر 2022، صفحه 147-154    اصل مقاله (488.26 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.95505.1146
نویسندگان
Sepideh Pouya1؛ Maryam Kazemi1، 2؛ Setareh Pouya3؛ Ali Dehshahri* 4؛ Zahra Sobhani5
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Optometry, Faculty of Rehabilitation, Iran University of Medical Sciences, Iran.
4Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5Drug and Food Control Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Gold nanoparticles (AuNPs) exhibit a variety of attractive physical, chemical, optical, thermal, and biological properties, making them potential candidates for non-toxic drug and gene delivery carriers. The surface modifications of AuNPs vastly enhance their circulation, minimize aggregation rates, and increase their targeting capability. In this investigation, cetyltrimethylammonium (CTAB) coated AuNPs were prepared and characterized for potential application in gene delivery. This surface modification can lead to the improvement of dispersibility and stability in aqueous solution, and surface charge density. In this study, CTAB coated AuNPs were complexed with plasmid DNA (pUMVC3-hIL-12) via electrostatic interaction and resulted in the formation of nano-sized CTAB-AuNP/plasmid DNA complexes with the size of 84.7±9.8 nm.  The zeta potential of these complexes was surface +4 mV at carrier: plasmid (C/P) ratio of 10. These complexes could condense the pDNA at C/P ratios of 8 and 10 and protect it against nuclease enzyme at C/P ratios of 4, 8, and 10. This study suggests that CTAB coated gold nanoparticles can be tested for potential applications in nucleic acid delivery. 
Keywords: Gene delivery, gold nanoparticles, cetyl trimethyl ammonium bromide, pUMVC3-hIL-12.
Please cite this article as: Sepideh Pouya, Maryam Kazemi, Setareh Pouya, Ali Dehshahri, Zahra Sobhani. Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery. Trends in Pharmaceutical Sciences. 2022;8(3):147-154. doi: 10.30476/TIPS.2022.95505.1146
کلیدواژه‌ها
Keywords: Gene delivery؛ gold nanoparticles؛ cetyl trimethyl ammonium bromide؛ pUMVC3-hIL-12
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