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Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. (1401). Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review. سامانه مدیریت نشریات علمی, 48(1), 13-25. doi: 10.30476/ijms.2021.91645.2289
Arash Amanlou; Ehsan Nassireslami; Ahmad Reza Dehpour; Amir Rashidian; Mohsen Chamanara. "Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review". سامانه مدیریت نشریات علمی, 48, 1, 1401, 13-25. doi: 10.30476/ijms.2021.91645.2289
Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. (1401). 'Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review', سامانه مدیریت نشریات علمی, 48(1), pp. 13-25. doi: 10.30476/ijms.2021.91645.2289
Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review. سامانه مدیریت نشریات علمی, 1401; 48(1): 13-25. doi: 10.30476/ijms.2021.91645.2289

Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review

Iranian Journal of Medical Sciences
مقاله 3، دوره 48، شماره 1، فروردین 2023، صفحه 13-25    اصل مقاله (304.24 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2021.91645.2289
نویسندگان
Arash Amanlou1؛ Ehsan Nassireslami2، 3؛ Ahmad Reza Dehpour1، 4؛ Amir Rashidian* 1، 4؛ Mohsen Chamanara* 2، 3
1Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
3Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran
4Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers. We aimed to review research studies that investigated the effect of statins on the prevention and treatment of seizures and epilepsy. Both animal models and human studies were included in this review. This article starts with a brief introduction about seizure, its prevalence, treatment, and various animal models of seizures and epilepsy. Next, we discuss statin’s mechanism of action, side effects, and effects on neurological disorders with a specific focus on seizures. Finally, the effects of different types of statins on seizures are compared. The present review gives a better understanding of the therapeutic effects of statins on neurological disorders in animal models and human studies. This permits researchers to set up study designs to resolve current ambiguities and contradictions on the beneficial effects of statins on neurological disorders.
کلیدواژه‌ها
Hydroxymethylglutaryl-CoA reductase inhibitors؛ HMG-CoA؛ Statins؛ Seizures؛ Epilepsy
سایر فایل های مرتبط با مقاله
مراجع
  1. Das RR, Herman ST. Statins in epilepsy: prime time? Not yet. Neurology. 2010;75:1490-1. doi: 10.1212/WNL.0b013e3181f962fc. PubMed PMID: 20975048.
  2. Singh A, Trevick S. The Epidemiology of Global Epilepsy. Neurol Clin. 2016;34:837-47. doi: 10.1016/j.ncl.2016.06.015. PubMed PMID: 27719996.
  3. Fisher RS. The New Classification of Seizures by the International League Against Epilepsy 2017. Curr Neurol Neurosci Rep. 2017;17:48. doi: 10.1007/s11910-017-0758-6. PubMed PMID: 28425015.
  4. Perucca P, Scheffer IE, Kiley M. The management of epilepsy in children and adults. Med J Aust. 2018;208:226-33. doi: 10.5694/mja17.00951. PubMed PMID: 29540143.
  5. Anurogo D, Ikrar T. Treatment of epilepsy: Background and future directions. Progress and Communication in Sciences. 2014;1:27-41.
  6. Rangel P, Cysneiros RM, Arida RM, de Albuquerque M, Colugnati DB, Scorza CA, et al. Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. Arq Neuropsiquiatr. 2005;63:972-6. doi: 10.1590/s0004-282x2005000600013. PubMed PMID: 16400415.
  7. Loscher W. Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs. Neurochem Res. 2017;42:1873-88. doi: 10.1007/s11064-017-2222-z. PubMed PMID: 28290134.
  8. Nirwan N, Vyas P, Vohora D. Animal models of status epilepticus and temporal lobe epilepsy: a narrative review. Rev Neurosci. 2018;29:757-70. doi: 10.1515/revneuro-2017-0086. PubMed PMID: 29565791.
  9. Golomb BA, Evans MA. Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs. 2008;8:373-418. doi: 10.2165/0129784-200808060-00004. PubMed PMID: 19159124; PubMed Central PMCID: PMCPMC2849981.
  10. Ramirez C, Tercero I, Pineda A, Burgos JS. Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment. J Alzheimers Dis. 2011;24:161-74. doi: 10.3233/JAD-2010-101653. PubMed PMID: 21224519.
  11. Ramkumar S, Raghunath A, Raghunath S. Statin Therapy: Review of Safety and Potential Side Effects. Acta Cardiol Sin. 2016;32:631-9. doi: 10.6515/acs20160611a. PubMed PMID: 27899849; PubMed Central PMCID: PMCPMC5126440.
  12. McFarland AJ, Anoopkumar-Dukie S, Arora DS, Grant GD, McDermott CM, Perkins AV, et al. Molecular mechanisms underlying the effects of statins in the central nervous system. Int J Mol Sci. 2014;15:20607-37. doi: 10.3390/ijms151120607. PubMed PMID: 25391045; PubMed Central PMCID: PMCPMC4264186.
  13. Evans M, Rees A. Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same? Drug Saf. 2002;25:649-63. doi: 10.2165/00002018-200225090-00004. PubMed PMID: 12137559.
  14. Schade DS, Shey L, Eaton RP. Prescribing Statins to Reduce Cardiovascular Disease: 10 Common Misconceptions. Am J Med. 2019;132:897-9. doi: 10.1016/j.amjmed.2019.01.042. PubMed PMID: 30851261.
  15. Lee JK, Won JS, Singh AK, Singh I. Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death. Neurosci Lett. 2008;440:260-4. doi: 10.1016/j.neulet.2008.05.112. PubMed PMID: 18583044; PubMed Central PMCID: PMCPMC2702849.
  16. Magan-Fernandez A, Rizzo M, Montalto G, Marchesini G. Statins in liver disease: not only prevention of cardiovascular events. Expert Rev Gastroenterol Hepatol. 2018;12:743-4. doi: 10.1080/17474124.2018.1477588. PubMed PMID: 29768950.
  17. Kosowski M, Smolarczyk-Kosowska J, Hachula M, Maliglowka M, Basiak M, Machnik G, et al. The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders. Molecules. 2021;26. doi: 10.3390/molecules26102838. PubMed PMID: 34064670; PubMed Central PMCID: PMCPMC8150718.
  18. Liberale L, Carbone F, Montecucco F, Sahebkar A. Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms. Int J Biochem Cell Biol. 2020;122:105735. doi: 10.1016/j.biocel.2020.105735. PubMed PMID: 32126319.
  19. Zeiser R. Immune modulatory effects of statins. Immunology. 2018;154:69-75. doi: 10.1111/imm.12902. PubMed PMID: 29392731; PubMed Central PMCID: PMCPMC5904709.
  20. Reiss AB, Wirkowski E. Statins in neurological disorders: mechanisms and therapeutic value. ScientificWorldJournal. 2009;9:1242-59. doi: 10.1100/tsw.2009.141. PubMed PMID: 19882094; PubMed Central PMCID: PMCPMC5823201.
  21. Borger MA, Seeburger J, Walther T, Borger F, Rastan A, Doenst T, et al. Effect of preoperative statin therapy on patients undergoing isolated and combined valvular heart surgery. Ann Thorac Surg. 2010;89:773-9. doi: 10.1016/j.athoracsur.2009.12.001. PubMed PMID: 20172126.
  22. Stepien K, Tomaszewski M, Czuczwar SJ. Neuroprotective properties of statins. Pharmacol Rep. 2005;57:561-9. PubMed PMID: 16227638.
  23. Johnson-Anuna LN, Eckert GP, Keller JH, Igbavboa U, Franke C, Fechner T, et al. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther. 2005;312:786-93. doi: 10.1124/jpet.104.075028. PubMed PMID: 15358814.
  24. Oesterle A, Laufs U, Liao JK. Pleiotropic Effects of Statins on the Cardiovascular System. Circ Res. 2017;120:229-43. doi: 10.1161/CIRCRESAHA.116.308537. PubMed PMID: 28057795; PubMed Central PMCID: PMCPMC5467317.
  25. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation. 2000;101:207-13. doi: 10.1161/01.cir.101.2.207. PubMed PMID: 10637210.
  26. Toth PP, Banach M. Statins: Then and Now. Methodist Debakey Cardiovasc J. 2019;15:23-31. doi: 10.14797/mdcj-15-1-23. PubMed PMID: 31049146; PubMed Central PMCID: PMCPMC6489607.
  27. Ward NC, Watts GF, Eckel RH. Statin Toxicity. Circ Res. 2019;124:328-50. doi: 10.1161/CIRCRESAHA.118.312782. PubMed PMID: 30653440.
  28. Namazi S, Borhani-Haghighi A, Karimzadeh I. Adverse reactions to antiepileptic drugs in epileptic outpatients: a cross-sectional study in iran. Clin Neuropharmacol. 2011;34:79-83. doi: 10.1097/WNF.0b013e318210ece0. PubMed PMID: 21412202.
  29. Khoshnoud MJ, Tanideh N, Namdarian S. Anticonvulsant activity of atorvastatin against seizure induced by pentylenetetrazole and maximal electroshock in mice. Trends in Pharmaceutical Sciences. 2015;1:44-7.
  30. Deckers CL, Czuczwar SJ, Hekster YA, Keyser A, Kubova H, Meinardi H, et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia. 2000;41:1364-74. doi: 10.1111/j.1528-1157.2000.tb00111.x. PubMed PMID: 11077449.
  31. Ballantyne CM, Corsini A, Davidson MH, Holdaas H, Jacobson TA, Leitersdorf E, et al. Risk for myopathy with statin therapy in high-risk patients. Arch Intern Med. 2003;163:553-64. doi: 10.1001/archinte.163.5.553. PubMed PMID: 12622602.
  32. Scicchitano F, Constanti A, Citraro R, De Sarro G, Russo E. Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions. Curr Drug Targets. 2015;16:747-56. doi: 10.2174/1389450116666150330114850. PubMed PMID: 25901524.
  33. Manford M. Recent advances in epilepsy. J Neurol. 2017;264:1811-24. doi: 10.1007/s00415-017-8394-2. PubMed PMID: 28120042; PubMed Central PMCID: PMCPMC5533817.
  34. Fracassi A, Marangoni M, Rosso P, Pallottini V, Fioramonti M, Siteni S, et al. Statins and the Brain: More than Lipid Lowering Agents? Curr Neuropharmacol. 2019;17:59-83. doi: 10.2174/1570159X15666170703101816. PubMed PMID: 28676012; PubMed Central PMCID: PMCPMC6341496.
  35. Yan J, Qiao L, Tian J, Liu A, Wu J, Huang J, et al. Effect of statins on Parkinson’s disease: A systematic review and meta-analysis. Medicine (Baltimore). 2019;98:e14852. doi: 10.1097/MD.0000000000014852. PubMed PMID: 30896628; PubMed Central PMCID: PMCPMC6709163.
  36. Nucera B, Rinaldi F, Nardone R, Lattanzi S, Brigo F. Statins in primary prevention of poststroke seizures and epilepsy: A systematic review. Epilepsy Behav. 2020;112:107400. doi: 10.1016/j.yebeh.2020.107400. PubMed PMID: 32916580.
  37. Kesim M, Yulug E, Kadioglu M, Erkoseoglu I, Aykan DA, Kalyoncu NI, et al. The effect of simvastatin on picrotoxin-induced seizure in mice. J Pak Med Assoc. 2012;62:1187-91. PubMed PMID: 23866408.
  38. Lee CY, Jaw T, Tseng HC, Chen IC, Liou HH. Lovastatin modulates glycogen synthase kinase-3beta pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. PLoS One. 2012;7:e38789. doi: 10.1371/journal.pone.0038789. PubMed PMID: 22761705; PubMed Central PMCID: PMCPMC3383707.
  39. Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T, et al. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma. 2007;24:1132-46. doi: 10.1089/neu.2007.0288. PubMed PMID: 17610353; PubMed Central PMCID: PMCPMC1971229.
  40. Xie C, Sun J, Qiao W, Lu D, Wei L, Na M, et al. Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy. PLoS One. 2011;6:e24966. doi: 10.1371/journal.pone.0024966. PubMed PMID: 21949812; PubMed Central PMCID: PMCPMC3176286.
  41. Oliveira CV, Zorzi VN, Fighera MR, Royes LFF, Furian AF, Oliveira MS. Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. Pharmacol Rep. 2018;70:364-71. doi: 10.1016/j.pharep.2017.08.016. PubMed PMID: 29477945.
  42. Banach M, Czuczwar SJ, Borowicz KK. Statins - are they anticonvulsant? Pharmacol Rep. 2014;66:521-8. doi: 10.1016/j.pharep.2014.02.026. PubMed PMID: 24948050.
  43. Gouveia TL, Scorza FA, Iha HA, Frangiotti MI, Perosa SR, Cavalheiro EA, et al. Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy. Epilepsy Behav. 2014;36:68-73. doi: 10.1016/j.yebeh.2014.04.009. PubMed PMID: 24857811.
  44. Gouveia TL, Scorza FA, Silva MJ, Bandeira Tde A, Perosa SR, Arganaraz GA, et al. Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus. Epilepsy Behav. 2011;20:1-5. doi: 10.1016/j.yebeh.2010.10.001. PubMed PMID: 21130693.
  45. Shafaroodi H, Moezi L, Fakhrzad A, Hassanipour M, Rezayat M, Dehpour AR. The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice. Neurol Res. 2012;34:847-53. doi: 10.1179/1743132812Y.0000000080. PubMed PMID: 22909758.
  46. Uzum G, Akgun-Dar K, Aksu U. The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats. Epilepsy Behav. 2010;19:284-9. doi: 10.1016/j.yebeh.2010.07.024. PubMed PMID: 20888302.
  47. Oliveira CV, Grigoletto J, Canzian JM, Duarte M, Duarte T, Furian AF, et al. Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. Epilepsy Behav. 2018;78:109-17. doi: 10.1016/j.yebeh.2017.10.021. PubMed PMID: 29186698.
  48. Citraro R, Chimirri S, Aiello R, Gallelli L, Trimboli F, Britti D, et al. Protective effects of some statins on epileptogenesis and depressive-like behavior in WAG/Rij rats, a genetic animal model of absence epilepsy. Epilepsia. 2014;55:1284-91. doi: 10.1111/epi.12686. PubMed PMID: 24962151.
  49. Stepien KM, Tomaszewski M, Luszczki JJ, Czuczwar SJ. The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model. Eur J Pharmacol. 2012;674:20-6. doi: 10.1016/j.ejphar.2011.10.030. PubMed PMID: 22056838.
  50. Guo J, Guo J, Li J, Zhou M, Qin F, Zhang S, et al. Statin treatment reduces the risk of poststroke seizures. Neurology. 2015;85:701-7. doi: 10.1212/WNL.0000000000001814. PubMed PMID: 26203092.
  51. Sierra-Marcos A, Alvarez V, Faouzi M, Burnand B, Rossetti AO. Statins are associated with decreased mortality risk after status epilepticus. Eur J Neurol. 2015;22:402-5. doi: 10.1111/ene.12428. PubMed PMID: 24684345.
  52. Siniscalchi A, Mintzer S. Statins for poststroke seizures: the first antiepileptogenic agent? Neurology. 2015;85:661-2. doi: 10.1212/WNL.0000000000001878. PubMed PMID: 26203090.
  53. Rong X, Yin J, Wang H, Zhang X, Peng Y. Statin treatment may lower the risk of postradiation epilepsy in patients with nasopharyngeal carcinoma. Epilepsia. 2017;58:2172-7. doi: 10.1111/epi.13924. PubMed PMID: 29034463.
  54. Saeedi Saravi SS, Saeedi Saravi SS, Arefidoust A, Dehpour AR. The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration. Metab Brain Dis. 2017;32:949-65. doi: 10.1007/s11011-017-0021-5. PubMed PMID: 28578514.
  55. Lin HW, Ho YF, Lin FJ. Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study. Br J Clin Pharmacol. 2018;84:1970-9. doi: 10.1111/bcp.13626. PubMed PMID: 29714813; PubMed Central PMCID: PMCPMC6089806.
  56. Quintana-Pajaro LJ, Ramos-Villegas Y, Cortecero-Sabalza E, Joaquim AF, Agrawal A, Narvaez-Rojas AR, et al. The Effect of Statins in Epilepsy: A Systematic Review. J Neurosci Rural Pract. 2018;9:478-86. doi: 10.4103/jnrp.jnrp_110_18. PubMed PMID: 30271037; PubMed Central PMCID: PMCPMC6126295.
  57. Trivedi LU, Alvarez CA, Mansi IA. Association of Statin Therapy With Risk of Epilepsy in 2 Propensity Score-Matched Cohorts. Ann Pharmacother. 2018;52:546-53. doi: 10.1177/1060028018756650. PubMed PMID: 29400081; PubMed Central PMCID: PMCPMC6650154.
  58. Henker C, Kriesen T, Scherer M, Glass A, von Deimling A, Bendszus M, et al. Association Between Tumor Compartment Volumes, the Incidence of Pretreatment Seizures, and Statin-Mediated Protective Effects in Glioblastoma. Neurosurgery. 2019;85:E722-E9. doi: 10.1093/neuros/nyz079. PubMed PMID: 30888031.
  59. Li Y, Zhang B, Zhang L, Xie D, Li Y. Efficacy of Statin therapy in post-stroke seizure prophylaxis: Clues from an observational study of routine secondary prevention treatment. Seizure. 2019;71:185-9. doi: 10.1016/j.seizure.2019.07.010. PubMed PMID: 31386961.
  60. Vitturi BK, Gagliardi RJ. The influence of statins on the risk of post-stroke epilepsy. Neurol Sci. 2020;41:1851-7. doi: 10.1007/s10072-020-04298-5. PubMed PMID: 32086686.
  61. Hsieh PF, Tung H, Lin CH. Statin effects on post-stroke epilepsy and mortality - Taiwan population-based study. Neurol Res. 2020;42:422-9. doi: 10.1080/01616412.2020.1735821. PubMed PMID: 32122287.
  62. Etminan M, Samii A, Brophy JM. Statin use and risk of epilepsy: a nested case-control study. Neurology. 2010;75:1496-500. doi: 10.1212/WNL.0b013e3181f96253. PubMed PMID: 20975051.
  63. Matsubara S, Tanaka T, Tomari S, Fukuma K, Ishiyama H, Abe S, et al. Statin treatment can reduce incidence of early seizure in acute ischemic stroke: A propensity score analysis. Sci Rep. 2020;10:1968. doi: 10.1038/s41598-020-58652-w. PubMed PMID: 32029801; PubMed Central PMCID: PMCPMC7005175.
  64. Guo Y, Zhu LH, Zhao K, Guo XM, Yang MF. Statin use for the prevention of seizure and epilepsy in the patients at risk: A systematic review and meta-analysis of cohort studies. Epilepsy Res. 2021;174:106652. doi: 10.1016/j.eplepsyres.2021.106652. PubMed PMID: 33971584.
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