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Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. (1401). Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review. سامانه مدیریت نشریات علمی, 48(1), 13-25. doi: 10.30476/ijms.2021.91645.2289
Arash Amanlou; Ehsan Nassireslami; Ahmad Reza Dehpour; Amir Rashidian; Mohsen Chamanara. "Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review". سامانه مدیریت نشریات علمی, 48, 1, 1401, 13-25. doi: 10.30476/ijms.2021.91645.2289
Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. (1401). 'Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review', سامانه مدیریت نشریات علمی, 48(1), pp. 13-25. doi: 10.30476/ijms.2021.91645.2289
Amanlou, Arash, Nassireslami, Ehsan, Dehpour, Ahmad Reza, Rashidian, Amir, Chamanara, Mohsen. Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review. سامانه مدیریت نشریات علمی, 1401; 48(1): 13-25. doi: 10.30476/ijms.2021.91645.2289

Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review

Iranian Journal of Medical Sciences
مقاله 3، دوره 48، شماره 1، فروردین 2023، صفحه 13-25    اصل مقاله (304.24 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2021.91645.2289
نویسندگان
Arash Amanlou1؛ Ehsan Nassireslami2، 3؛ Ahmad Reza Dehpour1، 4؛ Amir Rashidian* 1، 4؛ Mohsen Chamanara* 2، 3
1Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
3Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran
4Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers. We aimed to review research studies that investigated the effect of statins on the prevention and treatment of seizures and epilepsy. Both animal models and human studies were included in this review. This article starts with a brief introduction about seizure, its prevalence, treatment, and various animal models of seizures and epilepsy. Next, we discuss statin’s mechanism of action, side effects, and effects on neurological disorders with a specific focus on seizures. Finally, the effects of different types of statins on seizures are compared. The present review gives a better understanding of the therapeutic effects of statins on neurological disorders in animal models and human studies. This permits researchers to set up study designs to resolve current ambiguities and contradictions on the beneficial effects of statins on neurological disorders.
کلیدواژه‌ها
Hydroxymethylglutaryl-CoA reductase inhibitors؛ HMG-CoA؛ Statins؛ Seizures؛ Epilepsy
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مراجع
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