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Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. (1402). Quality of Life in Acromegaly Disease Among Iranian Population:One Longitudinal Before-After Study. سامانه مدیریت نشریات علمی, 10(2), 75-80. doi: 10.30476/jrsr.2022.91838.1188
Arezoo Chouhdari; Farnaz Saberian; Omidvar Rezaei; Mohammad Samadian; Kaveh Ebrahimzadeh; Guive Sharifi; Zahra Davoudi. "Quality of Life in Acromegaly Disease Among Iranian Population:One Longitudinal Before-After Study". سامانه مدیریت نشریات علمی, 10, 2, 1402, 75-80. doi: 10.30476/jrsr.2022.91838.1188
Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. (1402). 'Quality of Life in Acromegaly Disease Among Iranian Population:One Longitudinal Before-After Study', سامانه مدیریت نشریات علمی, 10(2), pp. 75-80. doi: 10.30476/jrsr.2022.91838.1188
Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. Quality of Life in Acromegaly Disease Among Iranian Population:One Longitudinal Before-After Study. سامانه مدیریت نشریات علمی, 1402; 10(2): 75-80. doi: 10.30476/jrsr.2022.91838.1188

Quality of Life in Acromegaly Disease Among Iranian Population:One Longitudinal Before-After Study

Journal of Rehabilitation Sciences & Research
مقاله 4، دوره 10، شماره 2، شهریور 2023، صفحه 75-80    اصل مقاله (709.09 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.30476/jrsr.2022.91838.1188
نویسندگان
Arezoo Chouhdari1، 2؛ Farnaz Saberian3؛ Omidvar Rezaei1؛ Mohammad Samadian1؛ Kaveh Ebrahimzadeh1؛ Guive Sharifi1؛ Zahra Davoudi* 1
1Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Social Determinants of Health Research Center, Amir-al-Momenin Hospital,Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: The current study aimed to determine the quality of life (QoL) scores before and after treatment in patients with acromegaly.
Methods: In this longitudinal before-after study, the acromegaly quality of life (AcroQoL) questionnaire was used to assess the QoL. Demographics, clinical manifestations and co-morbidity data, pituitary axis involvement, biochemical and hormonal component tests, and health-related quality of life (HRQoL) before and after treatment (endoscopic transsphenoidal surgery, medication, radiotherapy) were evaluated in patients over 18 years of age. To compare the mean of continuous data, the independent t and Mann–Whitney tests were used. To compare the mean QOL score before and after the study, the paired-t and Wilcoxon tests were performed. The significance level was set at p<0.05.
Results: Among 80 patients with acromegaly who underwent trans-sphenoid surgery with or without radiotherapy or medication therapy with somatostatin analogs, 52 (65%) entered the remission phase within 6 months. Associations were found between the remission phase and female gender (p=0.004) and lower growth hormone (GH) (p=0.04) but not between remission and lower insulin-like growth factor-I (IGF1) after surgery (p=0.02) or gonadal axis disorder after treatment (p<0.001) statistically. Moreover, a significant association was found between not being in the remission phase and gonadal axis disorder before treatment (p=0.04). The QoL score in all dimensions of the AcroQoL questionnaire increased 6 months after treatment (p<0.001). Total AcroQoL score was higher after treatment in the remission group (p=0.03). The psychological scale had a significantly higher score both on the total scale (p<0.001) and on the two subscales of appearance (p<0.001) and personal relationship (p=0.003).
Conclusion: Because of the importance of QoL in acromegaly patients, further studies in this field are recommended.
کلیدواژه‌ها
quality of life؛ acromegaly؛ growth hormone
مراجع
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