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Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. (1401). Quality of life in acromegaly disease among Iranian population: One longitudinal before- after study. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/jrsr.2022.91838.1188
Arezoo Chouhdari; Farnaz Saberian; Omidvar Rezaei; Mohammad Samadian; Kaveh Ebrahimzadeh; Guive Sharifi; Zahra Davoudi. "Quality of life in acromegaly disease among Iranian population: One longitudinal before- after study". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.30476/jrsr.2022.91838.1188
Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. (1401). 'Quality of life in acromegaly disease among Iranian population: One longitudinal before- after study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/jrsr.2022.91838.1188
Chouhdari, Arezoo, Saberian, Farnaz, Rezaei, Omidvar, Samadian, Mohammad, Ebrahimzadeh, Kaveh, Sharifi, Guive, Davoudi, Zahra. Quality of life in acromegaly disease among Iranian population: One longitudinal before- after study. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.30476/jrsr.2022.91838.1188

Quality of life in acromegaly disease among Iranian population: One longitudinal before- after study

Journal of Rehabilitation Sciences & Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 تیر 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.30476/jrsr.2022.91838.1188
نویسندگان
Arezoo Chouhdariorcid 1، 2؛ Farnaz Saberian3؛ Omidvar Rezaeiorcid 1؛ Mohammad Samadianorcid 1؛ Kaveh Ebrahimzadehorcid 1؛ Guive Sharifiorcid 1؛ Zahra Davoudi email orcid 1
1Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Social Determinants of Health Research Center, Amir-al-Momenin Hospital,Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background : We aimed to determine the quality of life(QoL) score before and after treatment in the patients with acromegaly.
 Methods: In this before-after study, AcroQol questionnaire was used to assess the QOL. Demographic, clinical manifestations and co-morbidity data, pituitary axis involvement, biochemical and hormonal component tests ,and HRQoL (Health-Related Quality of Life) before and after treatment (Endoscopic transsphenoidal surgery, medication , radiotherapy) were evaluated in the patients over 18. To compare the mean of continuous data independent t and Mann–Whitney test were used.  To compare the mean QOL score before and after study paired-t and Wilcoxon test performed.  The significance level was set up at p<0.05.
Results: Among 80 patients with acromegaly who underwent trans-sphenoid surgery with or without radiotherapy or medication therapy with somatostatin analogs 52(65%) entered the remission phase within 6 months. There was association between remission phase and female gender(p=0.004), lower growth hormone (GH) (p=0.04) so lower insulin like growth Factor-I (IGF1) after surgery(p=0.02) and no gonadal axis disorder after treatment(p<0.001) statistically. Also, there was significant association between not being in the remission phase and gonadal axis disorder before treatment (p=0.04). Qol score in all dimensions of the AcroQol questionnaire increased 6 months after treatment (p<0.001). Total AcroQol score after treatment was higher in remission group (p=0.03). As well as   psychological scale had a significant higher score both in the total scale (p<0.001) and in two subscale of appearance (p<0.001) and personal relationship (p=0.003).
Conclusion: Due to the importance of the Qol  in acromegaly patients, further studies in this field are recommended.
 
 
 
کلیدواژه‌ها
Quality of life؛ Acromegaly؛ Growth hormone
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