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Mahzoni, Hamed, Sharifi, Mehran, Moghaddas, Azadeh. (1401). Futile Medication in Palliative Cancer Patients; a Report from the Middle East. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2022.93301.1683
Hamed Mahzoni; Mehran Sharifi; Azadeh Moghaddas. "Futile Medication in Palliative Cancer Patients; a Report from the Middle East". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.30476/mejc.2022.93301.1683
Mahzoni, Hamed, Sharifi, Mehran, Moghaddas, Azadeh. (1401). 'Futile Medication in Palliative Cancer Patients; a Report from the Middle East', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2022.93301.1683
Mahzoni, Hamed, Sharifi, Mehran, Moghaddas, Azadeh. Futile Medication in Palliative Cancer Patients; a Report from the Middle East. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.30476/mejc.2022.93301.1683

Futile Medication in Palliative Cancer Patients; a Report from the Middle East

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 تیر 1401  XML اصل مقاله (404.64 K)
نوع مقاله: Brief Report
شناسه دیجیتال (DOI): 10.30476/mejc.2022.93301.1683
نویسندگان
Hamed Mahzoniorcid 1؛ Mehran Sharifi2؛ Azadeh Moghaddas email orcid 1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Internal Medicine, Oncology and Hematology Section, Faculty of Medicine, Isfahan University Medical Sciences, Isfahan, Iran
چکیده
Background: Palliative cancer patients suffer from a condition which needs to take many medications for supportive care and comorbid illnesses management. Therefore, they are at risk of drug-rated problems, such as futile medications. We aimed to discover the futile medication occurrence and identification as well as medication futility associated predictor factors.
Method: In a prospective cross-sectional study, we included patients with advanced/incurable malignancies admitted to Ala palliative clinic, a charity clinic affiliated to Omid hospital in Isfahan, Iran, between June 2018 and April 2019. To identify the use of fruitless medicine towards the end of life, we conducted a thorough analysis of the demographic information and prescription lists of terminally ill patients. The phrase "futile drugs" refers to those that are superfluous or redundant, have no significant benefits in terms of illness symptom management or survival time extension, or have a long-term chronic usage.
Results: From 133 involved patients, 114 (85.7%) were considered to use at least one futile medication (including only administration of unnecessary medications (70%) or both unnecessary and duplicate medication (30%). 35 patients were encountered with 48 medication duplications of the different pharmacological class of medications mostly opioids (33%). According to multivariate logistic regression analysis, the number of drugs and the average time to death were related with the prevalence of medication futility.   
Conclusion: Palliative cancer patients were exposed to taking futile medications. More different prospective studies are warranted to evaluate the clinical and economic impact of futile medication use in oncology practice.
کلیدواژه‌ها
Cancer؛ Drug therapy؛ Medical futility؛ Palliative care
مراجع
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