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Nedeva, Iveta, Gateva, Antoaneta, Assyov, Yavor, Karamfilova, Vera, Hristova, Julieta, Yamanishi, Kyosuke, Kamenov, Zdravko, Okamura, Haruki. (1401). IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes. سامانه مدیریت نشریات علمی, 19(2), 193-200. doi: 10.22034/iji.2022.90095.1987
Iveta Nedeva; Antoaneta Gateva; Yavor Assyov; Vera Karamfilova; Julieta Hristova; Kyosuke Yamanishi; Zdravko Kamenov; Haruki Okamura. "IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes". سامانه مدیریت نشریات علمی, 19, 2, 1401, 193-200. doi: 10.22034/iji.2022.90095.1987
Nedeva, Iveta, Gateva, Antoaneta, Assyov, Yavor, Karamfilova, Vera, Hristova, Julieta, Yamanishi, Kyosuke, Kamenov, Zdravko, Okamura, Haruki. (1401). 'IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes', سامانه مدیریت نشریات علمی, 19(2), pp. 193-200. doi: 10.22034/iji.2022.90095.1987
Nedeva, Iveta, Gateva, Antoaneta, Assyov, Yavor, Karamfilova, Vera, Hristova, Julieta, Yamanishi, Kyosuke, Kamenov, Zdravko, Okamura, Haruki. IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1401; 19(2): 193-200. doi: 10.22034/iji.2022.90095.1987

IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes

Iranian Journal of Immunology
مقاله 7، دوره 19، شماره 2، شهریور 2022، صفحه 193-200    اصل مقاله (736.58 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2022.90095.1987
نویسندگان
Iveta Nedeva* 1؛ Antoaneta Gateva1؛ Yavor Assyov1؛ Vera Karamfilova1؛ Julieta Hristova2؛ Kyosuke Yamanishi3؛ Zdravko Kamenov1؛ Haruki Okamura3
1Clinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, Bulgaria
2Clinical Laboratory and Clinical Pharmacology, University Hospital “Alexandrovska”, Department of Clinical Laboratory, Medical University-Sofia, Bulgaria
3Department of Psychoimmunology, Hyogo College of Medicine, Japan
چکیده
Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders. Methods: This study included 387 Caucasians divided into four groups: healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics. Results: Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly higher levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647). Conclusion: Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.
کلیدواژه‌ها
Carbohydrate Disturbances؛ IL-18؛ Metabolic Syndrome
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