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Elsayed, Walid, Harb, Ola, Obaya, Ahmed, Elsayed, Dalia, Gertallah, Loay, Mawla, Walid, Abd El Fattah, Ahmed. (1401). Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance. سامانه مدیریت نشریات علمی, 14(1), 29-40. doi: 10.30476/mejc.2022.89869.1551
Walid S. H. Elsayed; Ola A. Harb; Ahmed A. Obaya; Dalia Hamouda Elsayed; Loay M. Gertallah; Walid A Mawla; Ahmed Raafat Abd El Fattah. "Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance". سامانه مدیریت نشریات علمی, 14, 1, 1401, 29-40. doi: 10.30476/mejc.2022.89869.1551
Elsayed, Walid, Harb, Ola, Obaya, Ahmed, Elsayed, Dalia, Gertallah, Loay, Mawla, Walid, Abd El Fattah, Ahmed. (1401). 'Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance', سامانه مدیریت نشریات علمی, 14(1), pp. 29-40. doi: 10.30476/mejc.2022.89869.1551
Elsayed, Walid, Harb, Ola, Obaya, Ahmed, Elsayed, Dalia, Gertallah, Loay, Mawla, Walid, Abd El Fattah, Ahmed. Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance. سامانه مدیریت نشریات علمی, 1401; 14(1): 29-40. doi: 10.30476/mejc.2022.89869.1551

Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance

Middle East Journal of Cancer
مقاله 3، دوره 14، شماره 1 - شماره پیاپی 53، فروردین 2023، صفحه 29-40    اصل مقاله (4.82 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2022.89869.1551
نویسندگان
Walid S. H. Elsayed1؛ Ola A. Harb* 1؛ Ahmed A. Obaya2؛ Dalia Hamouda Elsayed3؛ Loay M. Gertallah4؛ Walid A Mawla4؛ Ahmed Raafat Abd El Fattah4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Department of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
چکیده
Background: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-1 (YAP-1) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes. Annexin A10 (ANXA10) is a member of annexin family. Uncoordinated-5D (UNC5D), a recently discovered Unc5 family member which is found in normal tissues and downregulated in cancer cell lines and tissues. Aim of the study was to assess the expression of YAP-1, ANXA10, and UNC5D in PTC and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in PTC patients.
Method: In the present prospective study, we took samples from 60 patients with PTC and 30 samples from non-neoplastic thyroid tissues for YAP-1, ANXA10, and UNC5D immunohistochemistry. All the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.
Results: Upregulation of YAP-1 and ANXA10 in addition to downregulation of UNC5D was found in PTC tissues more than non-neoplastic thyroid tissues. In PTC tissues, there were positive associations between high YAP-1 and ANXA10 expression, low UNC5D expression, tumor size (P = 0.022, 0.011, 0.014), presence of lymph node metastases (P = 0.005, < 0.001, 0.008), and inferior disease-free survival rate (P = 0.003, 0.01, 0.03).
Conclusion: Upregulation of YAP-1 and ANXA10 expression and downregulation of UNC5D was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival.
کلیدواژه‌ها
YAP-1 protein؛ ANXA10؛ UNC5D؛ PTC؛ Immunohistochemistry؛ Prognosis
مراجع
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