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Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases | ||
| Iranian Journal of Immunology | ||
| مقاله 1، دوره 19، شماره 2، شهریور 2022، صفحه 121-138 اصل مقاله (1 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2022.92653.2164 | ||
| نویسندگان | ||
| Sara Iranparast1، 2؛ Farhad Seif3، 4؛ Sanaz Tayebi1، 2؛ Farhad Abolnezhadian5؛ Moosa Sharifat1؛ Alireza Fazaeli6؛ Neda Roshanravan7؛ Azam Samei8؛ Sholeh Khajoei* 9 | ||
| 1Department of Immunology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 2Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 3Department of Immunology and Allergy, Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran | ||
| 4Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran | ||
| 5Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 6Rheumatology Department, Hamadan University of Medical Sciences, Hamadan, Iran | ||
| 7Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 8Department of Laboratory Sciences, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran | ||
| 9Clinical Research Development Center, Imam Khomeini Hospital, Jiroft University of Medical Sciences, Jiroft, Iran | ||
| چکیده | ||
| Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific B cells in the germinal center. TFH cells are distinct from other established CD4+ T cell subsets and possess a list of transcription factors, including BCL6, IRF4, c-Maf, Batf, NFAT1-2, and STAT3. The mentioned factors direct several activities such as cell differentiation, migration to the follicles, cell-to-cell interaction, as well as cell programming. Given that TFH cells are essential for the germinal center formation, affinity maturation and the development of most high-affinity antibodies. TFH cells may play crucial roles in different pathologic conditions, particularly autoimmune diseases. However, the mechanisms that cause functional differences of TFH cell responses are not exactly defined. In this review first the immunological profile of TFH cells will be discussed then attempts will be made to give a broad picture on the role of this key subset of T cells in autoimmune diseases. | ||
| کلیدواژه‌ها | ||
| Autoimmune Diseases؛ Chemokine؛ Follicular Helper T Cell؛ Germinal Center؛ Interleukin؛ Transcription Factor | ||
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آمار تعداد مشاهده مقاله: 1,646 تعداد دریافت فایل اصل مقاله: 998 |
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