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Sharifzadeh Javidi, Sam, Shirazinodeh, Alireza, Saligheh Rad, Hamidreza. (1401). Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study. سامانه مدیریت نشریات علمی, (), -.
Sam Sharifzadeh Javidi; Alireza Shirazinodeh; Hamidreza Saligheh Rad. "Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study". سامانه مدیریت نشریات علمی, , , 1401, -.
Sharifzadeh Javidi, Sam, Shirazinodeh, Alireza, Saligheh Rad, Hamidreza. (1401). 'Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study', سامانه مدیریت نشریات علمی, (), pp. -.
Sharifzadeh Javidi, Sam, Shirazinodeh, Alireza, Saligheh Rad, Hamidreza. Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study. سامانه مدیریت نشریات علمی, 1401; (): -.

Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 08 تیر 1401  XML اصل مقاله (1015.82 K)
نوع مقاله: Original Research
نویسندگان
Sam Sharifzadeh Javidi email orcid 1، 2؛ Alireza Shirazinodeh1؛ Hamidreza Saligheh Rad email orcid 3، 4
1PhD Candidate, Department of Medical Physics and Biomedical Engineering, Medicine School, Tehran University of Medical Sciences, Tehran, Iran
2PhD Candidate, Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
3PhD, Department of Medical Physics and Biomedical Engineering, Medicine School, Tehran University of Medical Sciences, Tehran, Iran
4PhD, Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: The intravoxel incoherent motion (IVIM) model extracts both functional and structural information of a tissue using motion-sensitizing gradients. 
Objective: The Objective of the present work is to investigate the impact of signal to noise ratio (SNR) and physiologic conditions on the validity of IVIM parameters.
Material and Methods: This study is a simulation study, modeling IVIM at a voxel, and also done 10,000 times for every single simulation. Complex noises with various standard deviations were added to signal in-silico to investigate SNR effects on output validity. Besides, some blood perfusion situations for different tissues were considered based on their physiological range to explore the impacts of blood fraction at each voxel on the validity of the IVIM outputs. Coefficient variation (CV) and bias of the estimations were computed to assess the validity of the IVIM parameters. 
Results: This study has shown that the validity of IVIM output parameters highly depends on measurement SNR and physiologic characteristics of the studied organ.  
Conclusion: IVIM imaging could be useful if imaging parameters are correctly selected for each specific organ, considering hardware limitations.
کلیدواژه‌ها
Reproducibility of Results؛ Diffusion-Weighted Imaging؛ Perfusion Imaging؛ Intravoxel Incoherent Motion؛ SNR؛ Magnetic Resonance Imaging
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