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Ghasemiyeh, Parisa, Noorizadeh, Kiarash, Dehghan, Dorsa, Rasekh, Shiva, Zadmehr, Ouriel, Mohammadi-Samani, Soliman. (1401). The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review. سامانه مدیریت نشریات علمی, 8(2), 107-118. doi: 10.30476/tips.2022.95146.1142
Parisa Ghasemiyeh; Kiarash Noorizadeh; Dorsa Dehghan; Shiva Rasekh; Ouriel Zadmehr; Soliman Mohammadi-Samani. "The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review". سامانه مدیریت نشریات علمی, 8, 2, 1401, 107-118. doi: 10.30476/tips.2022.95146.1142
Ghasemiyeh, Parisa, Noorizadeh, Kiarash, Dehghan, Dorsa, Rasekh, Shiva, Zadmehr, Ouriel, Mohammadi-Samani, Soliman. (1401). 'The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review', سامانه مدیریت نشریات علمی, 8(2), pp. 107-118. doi: 10.30476/tips.2022.95146.1142
Ghasemiyeh, Parisa, Noorizadeh, Kiarash, Dehghan, Dorsa, Rasekh, Shiva, Zadmehr, Ouriel, Mohammadi-Samani, Soliman. The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review. سامانه مدیریت نشریات علمی, 1401; 8(2): 107-118. doi: 10.30476/tips.2022.95146.1142

The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review

Trends in Pharmaceutical Sciences
مقاله 7، دوره 8، شماره 2، شهریور 2022، صفحه 107-118    اصل مقاله (629.63 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.95146.1142
نویسندگان
Parisa Ghasemiyeh1، 2؛ Kiarash Noorizadeh3؛ Dorsa Dehghan3؛ Shiva Rasekh4؛ Ouriel Zadmehr4؛ Soliman Mohammadi-Samani* 2، 5
1Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Acne vulgaris is a chronic multifactorial skin disease that millions of people around the world of suffering from that. Pathophysiology of acne consists of several mechanisms including hyper-seborrhea, hyperkeratinization of pilosebaceous units, increased bacterial proliferation, hyperandrogenism, alteration in sebum contents, and inflammatory processes. In this regard, consideration of the main causes of acne development and severity of acne lesions in the selection of suitable pharmacologic agents is essential. In this review, among the other factors, the role of the different lipids in pathophysiology of acne were considered. The common sources of skin lipids have been categorized into two main categories including endogenous and exogenous sources. Furthermore, the role of different factors including lipids and fatty acids, androgens, microorganisms, cosmeceuticals, and lipids oxidation and peroxides in acne vulgaris development have been summarized. In the end, the necessity of the choice of appropriate pharmacotherapy regimens and recruitment of novel drug delivery systems in acne management have been mentioned. 
Please cite this article as: Parisa Ghasemiyeh, Kiarash Noorizadeh, Dorsa Dehghan, Shiva Rasekh, Ouriel Zadmehr, Soliman Mohammadi-Samani. The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Targets: A Brief Review. Trends in Pharmaceutical Sciences. 2022;8(2):107-118. doi: 10.30476/TIPS.2022.95146.1142
کلیدواژه‌ها
Acne؛ Pathophysiology؛ Lipids؛ Microorganisms؛ Androgens؛ Cosmeceuticals
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