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Soraya, Hamid, Sheikholeslami, Sama, Shirpoor, Alireza, Nezami Majd, Farideh, Naderi, Roya, Rasmi, Yousef. (1401). Influence of Maternal Ethanol Exposure on Systemic Hemodynamic Variables and Histopathological Changes in the Aorta Wall of Male Rat Offspring: A Three-month Follow-up. سامانه مدیریت نشریات علمی, 47(5), 468-476. doi: 10.30476/ijms.2021.91047.2205
Hamid Soraya; Sama Sheikholeslami; Alireza Shirpoor; Farideh Nezami Majd; Roya Naderi; Yousef Rasmi. "Influence of Maternal Ethanol Exposure on Systemic Hemodynamic Variables and Histopathological Changes in the Aorta Wall of Male Rat Offspring: A Three-month Follow-up". سامانه مدیریت نشریات علمی, 47, 5, 1401, 468-476. doi: 10.30476/ijms.2021.91047.2205
Soraya, Hamid, Sheikholeslami, Sama, Shirpoor, Alireza, Nezami Majd, Farideh, Naderi, Roya, Rasmi, Yousef. (1401). 'Influence of Maternal Ethanol Exposure on Systemic Hemodynamic Variables and Histopathological Changes in the Aorta Wall of Male Rat Offspring: A Three-month Follow-up', سامانه مدیریت نشریات علمی, 47(5), pp. 468-476. doi: 10.30476/ijms.2021.91047.2205
Soraya, Hamid, Sheikholeslami, Sama, Shirpoor, Alireza, Nezami Majd, Farideh, Naderi, Roya, Rasmi, Yousef. Influence of Maternal Ethanol Exposure on Systemic Hemodynamic Variables and Histopathological Changes in the Aorta Wall of Male Rat Offspring: A Three-month Follow-up. سامانه مدیریت نشریات علمی, 1401; 47(5): 468-476. doi: 10.30476/ijms.2021.91047.2205

Influence of Maternal Ethanol Exposure on Systemic Hemodynamic Variables and Histopathological Changes in the Aorta Wall of Male Rat Offspring: A Three-month Follow-up

Iranian Journal of Medical Sciences
مقاله 9، دوره 47، شماره 5، آذر 2022، صفحه 468-476    اصل مقاله (2.38 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.91047.2205
نویسندگان
Hamid Soraya1؛ Sama Sheikholeslami2؛ Alireza Shirpoor* 2، 3؛ Farideh Nezami Majd2؛ Roya Naderi2، 3؛ Yousef Rasmi4
1Department of Pharmacology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
2Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
4Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
چکیده
Background: Alcohol consumption in pregnancy is associated with an increased risk of cardiovascular abnormalities, but the mechanisms are unknown. This study evaluated the impact of ethanol exposure on the offspring’s aorta structural, functional, and molecular alterations on postnatal (PN) both on days 21 and 90.
Methods: This experimental study was conducted at Urmia University of Medical Sciences (Urmia, Iran) in 2019. Twenty Pregnant Wistar rats on the seventh day of Gestation Day (GD) were randomly divided into two groups: control and ethanol-treated groups (n=10 per group). From the seventh day of GD throughout lactation, rats in the ethanol group were fed binge alcohol (4.5 g/Kg body weight) once daily. Systemic hemodynamic variables in the offspring were analyzed using waveform contour analysis 90 days after birth. On postnatal days (PN) 21 and 90, aorta wall histological alterations and the level of inflammatory factors were assessed in the aorta of male offspring. The statistical differences were examined via an independent samples t test. P<0.05 was considered to be statistically significant. 
Results: The results revealed that offspring in the ethanol group had higher systolic, diastolic, mean arterial pressure, and dicrotic pressure than the control group (P<0.001). The level of aorta tissue tumor necrosis factor (TNF)-α, intercellular adhesion molecule (ICAM)-1, nuclear factor (NF)-κ, and endothelin-1 were significantly higher in the ethanol offspring group than in the control group (P<0.001). Histopathological changes such as total aorta thickness, tunica media, tunica adventitia, elastin fiber thickness, fiber interval, and elastin/media ratio significantly increased in the aorta of the offspring of the ethanol group compared to the control group 21 and 90 days after birth. 
Conclusion: Our findings suggest that prenatal and early postnatal ethanol exposure-induced cardiovascular abnormalities are, in part, due to predisposing the aorta to atherosclerosis, which was mediated through the aorta wall remodeling and inflammation process. 
کلیدواژه‌ها
Pregnancy؛ Ethanol؛ Aorta؛ Blood pressure؛ Rat
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مراجع
  1. Kesmodel U, Olsen SF, Secher NJ. Does alcohol increase the risk of preterm delivery? Epidemiology. 2000;11:512-8. doi: 10.1097/00001648-200009000-00005. PubMed PMID: 10955402.
  2. Sokol RJ, Delaney-Black V, Nordstrom B. Fetal alcohol spectrum disorder. JAMA. 2003;290:2996-9. doi: 10.1001/jama.290.22.2996. PubMed PMID: 14665662.
  3. Pruett D, Waterman EH, Caughey AB. Fetal alcohol exposure: consequences, diagnosis, and treatment. Obstet Gynecol Surv. 2013;68:62-9. doi: 10.1097/OGX.0b013e31827f238f. PubMed PMID: 23322082.
  4. Parkington HC, Kenna KR, Sozo F, Coleman HA, Bocking A, Brien JF, et al. Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheep. J Physiol. 2014;592:2591-603. doi: 10.1113/jphysiol.2013.262873. PubMed PMID: 24756643; PubMed Central PMCID: PMCPMC4080940. 
  5. Shirpoor A, Nemati S, Ansari MH, Ilkhanizadeh B. The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: a 3-month follow-up study. Int Immunopharmacol. 2015;26:72-9. doi: 10.1016/j.intimp.2015.03.008. PubMed PMID: 25805307.
  6. Turcotte LA, Aberle NS, Norby FL, Wang GJ, Ren J. Influence of prenatal ethanol exposure on vascular contractile response in rat thoracic aorta. Alcohol. 2002;26:75-81. doi: 10.1016/s0741-8329(01)00198-7. PubMed PMID: 12007582.
  7. Kvigne VL, Leonardson GR, Neff-Smith M, Brock E, Borzelleca J, Welty TK. Characteristics of children who have full or incomplete fetal alcohol syndrome. J Pediatr. 2004;145:635-40. doi: 10.1016/j.jpeds.2004.07.015. PubMed PMID: 15520764.
  8. Morley R, Dwyer T, Hynes KL, Cochrane J, Ponsonby AL, Parkington HC, et al. Maternal alcohol intake and offspring pulse wave velocity. Neonatology. 2010;97:204-11. doi: 10.1159/000252973. PubMed PMID: 19864927; PubMed Central PMCID: PMCPMC3701444.
  9. Shirpoor A, Salami S, Khadem-Ansari MH, Minassian S, Yegiazarian M. Protective effect of vitamin E against ethanol-induced hyperhomocysteinemia, DNA damage, and atrophy in the developing male rat brain. Alcohol Clin Exp Res. 2009;33:1181-6. doi: 10.1111/j.1530-0277.2009.00941.x. PubMed PMID: 19389196.
  10. Shirpoor A, Norouzi L, Khadem-Ansari MH, Ilkhanizadeh B, Karimipour M. The Protective Effect of Vitamin E on Morphological and Biochemical Alteration Induced by Pre and Postnatal Ethanol Administration in the Testis of Male Rat Offspring: A Three Months Follow-up Study. J Reprod Infertil. 2014;15:134-41. PubMed PMID: 25202670; PubMed Central PMCID: PMCPMC4138419.
  11. Shirpoor A, Salami S, Khadem-Ansari MH, Heshmatian B, Ilkhanizadeh B. Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. Vascul Pharmacol. 2012;57:72-7. doi: 10.1016/j.vph.2012.04.001. PubMed PMID: 22521742.
  12. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988;41:467-70. doi: 10.1136/jcp.41.4.467. PubMed PMID: 3366935; PubMed Central PMCID: PMCPMC1141479.
  13. Nguyen VB, Probyn ME, Campbell F, Yin KV, Samuel CS, Zimanyi MA, et al. Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood. Physiol Rep. 2014;2. doi: 10.14814/phy2.12087. PubMed PMID: 25077510; PubMed Central PMCID: PMCPMC4187541.
  14. Gray SP, Denton KM, Cullen-McEwen L, Bertram JF, Moritz KM. Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny. J Am Soc Nephrol. 2010;21:1891-902. doi: 10.1681/ASN.2010040368. PubMed PMID: 20829403; PubMed Central PMCID: PMCPMC3014004.
  15. Gray SP, Kenna K, Bertram JF, Hoy WE, Yan EB, Bocking AD, et al. Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2008;295:R568-74. doi: 10.1152/ajpregu.90316.2008. PubMed PMID: 18565833.
  16. Fritz M, Rinaldi G. Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: influence of adrenergic- and nitric oxide-mediated vasomotion. J Pharmacol Toxicol Methods. 2008;58:215-21. doi: 10.1016/j.vascn.2008.08.002. PubMed PMID: 18765287.
  17. Ibrahim J, Berk BC, Hughes AD. Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens. 2006;28:57-72. doi: 10.1080/10641960500386817. PubMed PMID: 16443565.
  18. Alastruey J, Nagel SR, Nier BA, Hunt AA, Weinberg PD, Peiro J. Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis. J Biomech. 2009;42:2116-23. doi: 10.1016/j.jbiomech.2009.05.028. PubMed PMID: 19646697.
  19. Chowienczyk PJ, Kelly RP, MacCallum H, Millasseau SC, Andersson TL, Gosling RG, et al. Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus. J Am Coll Cardiol. 1999;34:2007-14. doi: 10.1016/s0735-1097(99)00441-6. PubMed PMID: 10588217.
  20. Woodman RJ, Watts GF. Measurement and application of arterial stiffness in clinical research: focus on new methodologies and diabetes mellitus. Med Sci Monit. 2003;9:RA81-9. PubMed PMID: 12761466.
  21. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236-41. doi: 10.1161/01.hyp.37.5.1236. PubMed PMID: 11358934.
  22. Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension. 1998;32:570-4. doi: 10.1161/01.hyp.32.3.570. PubMed PMID: 9740628.
  23. Wolinsky H. Long-term effects of hypertension on the rat aortic wall and their relation to concurrent aging changes. Morphological and chemical studies. Circ Res. 1972;30:301-9. doi: 10.1161/01.res.30.3.301. PubMed PMID: 5060432.
  24. Demircioglu F, Kocyigit A, Arslan N, Cakmakci H, Hizli S, Sedat AT. Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2008;47:68-75. doi: 10.1097/MPG.0b013e31816232c9. PubMed PMID: 18607271. 
  25. Deltour L, Ang HL, Duester G. Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. FASEB J. 1996;10:1050-7. PubMed PMID: 8801166.
  26. Brennan D, Giles S. Sonic hedgehog expression is disrupted following in ovo ethanol exposure during early chick eye development. Reprod Toxicol. 2013;41:49-56. doi: 10.1016/j.reprotox.2013.05.012. PubMed PMID: 23751449.
  27. Serrano M, Han M, Brinez P, Linask KK. Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. Am J Obstet Gynecol. 2010;203:75. doi: 10.1016/j.ajog.2010.03.017. PubMed PMID: 20451895.
  28. Jayachandran M, Chandrasekaran B, Namasivayam N. Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-kappaB signaling pathway. Eur J Pharmacol. 2015;762:102-11. doi: 10.1016/j.ejphar.2015.05.039. PubMed PMID: 26004525.
  29. Baker RG, Hayden MS, Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab. 2011;13:11-22. doi: 10.1016/j.cmet.2010.12.008. PubMed PMID: 21195345; PubMed Central PMCID: PMCPMC3040418.
  30. Zhang T, Sun L, Liu R, Zhang D, Lan X, Huang C, et al. A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages. Mol Pharm. 2012;9:671-7. doi: 10.1021/mp2003779. PubMed PMID: 22292506.
  31. Kim SR, Bae YH, Bae SK, Choi KS, Yoon KH, Koo TH, et al. Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Biochim Biophys Acta. 2008;1783:886-95. doi: 10.1016/j.bbamcr.2008.01.004. PubMed PMID: 18241674.
  32. Cominacini L, Pasini A, Garbin U, Evangelista S, Crea AE, Tagliacozzi D, et al. Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species. Am J Hypertens. 2002;15:891-5. doi: 10.1016/s0895-7061(02)02995-3. PubMed PMID: 12372676.
  33. Zhang Y, Yang X, Bian F, Wu P, Xing S, Xu G, et al. TNF-alpha promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-kappaB and PPAR-gamma. J Mol Cell Cardiol. 2014;72:85-94. doi: 10.1016/j.yjmcc.2014.02.012. PubMed PMID: 24594319.
  34. Song D, Fang G, Mao SZ, Ye X, Liu G, Miller EJ, et al. Selective inhibition of endothelial NF-kappaB signaling attenuates chronic intermittent hypoxia-induced atherosclerosis in mice. Atherosclerosis. 2018;270:68-75. doi: 10.1016/j.atherosclerosis.2018.01.027. PubMed PMID: 29407890.
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