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Faraji, Shahab, Moosavi, Seyed Akbar, Neshasteh-riz, Ali, Cheraghi, Susan, Mayahi, Sara. (1401). Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes. سامانه مدیریت نشریات علمی, (), -. doi: 10.31661/jbpe.v0i0.2109-1409
Shahab Faraji; Seyed Akbar Moosavi; Ali Neshasteh-riz; Susan Cheraghi; Sara Mayahi. "Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.31661/jbpe.v0i0.2109-1409
Faraji, Shahab, Moosavi, Seyed Akbar, Neshasteh-riz, Ali, Cheraghi, Susan, Mayahi, Sara. (1401). 'Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.31661/jbpe.v0i0.2109-1409
Faraji, Shahab, Moosavi, Seyed Akbar, Neshasteh-riz, Ali, Cheraghi, Susan, Mayahi, Sara. Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.31661/jbpe.v0i0.2109-1409

Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 30 خرداد 1401    اصل مقاله (840.95 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2109-1409
نویسندگان
Shahab Faraji1؛ Seyed Akbar Moosavi2؛ Ali Neshasteh-riz3، 4؛ Susan Cheraghi* 3، 4؛ Sara Mayahi1
1MSc, Department of Radiation Sciences, Faculty of Paramedicine, Iran University of Medical Sciences, Tehran, Iran
2PhD, Department of Laboratory Sciences, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
3PhD, Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
4PhD, Department of Radiation Sciences, Faculty of Paramedicine, Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, Iran
چکیده
Background: High-dose radiation altering the genetic material in patients’ bone marrow cells can lead to hematopoietic radiation syndrome. Accordingly, the presence of radiation protections agents is critical to preventing these adverse effects. 
Objective: This study aimed to evaluate the radioprotection of the exclusive or combination effect of resveratrol and crocin extracts at various concentrations on irradiated human lymphocytes.
Material and Methods: In this experimental study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to evaluate the cell viability in pre-treatment with resveratrol, crocin, or a combination of both, using a concentration range of 5 to 4800 μM / ml in 24 h. The chromosomal aberration test was employed to determine the aberration frequency in 48 h. This study was performed on human peripheral blood lymphocytes treated with 2 Gy radiation and reliability of measurements performed by the triplicate repeat. 
Results: MTT results showed that the groups treated with either resveratrol or crocin at concentrations of 5 to 4800 µM had no significant reduction in cell viability. The cytogenetic analysis of irradiated lymphocytes with 2 Gy X-rays revealed a reduction in the frequency of dicentric chromosomes in all treated groups in contrast with the control group. The most significant reduction occurred in those treated with a single agent at the concentration of 100 µM and a combined drug at the concentration of 50 µM.  
Conclusion: The combination of resveratrol and crocin is considered a potential radioprotector and prophylactic for patients before radiation therapy.
کلیدواژه‌ها
Radiation protection؛ Resveratrol؛ Crocin؛ DNA Damage؛ Human Lymphocyte؛ Chromosome Aberrations
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