The Impact of Body Mass Index on Pathological Response and Survival Outcome after Neoadjuvant Chemotherapy in Localized Bladder Cancer | ||
| Middle East Journal of Cancer | ||
| مقاله 14، دوره 14، شماره 1 - شماره پیاپی 53، 2023، صفحه 136-145 اصل مقاله (1.88 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2022.90799.1591 | ||
| نویسندگان | ||
| Amrallah Mohammed* 1؛ Fifi Elsayed2؛ Reham Salem3، 4 | ||
| 1Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 3Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 4Department of Radiation Therapy Princess Nourah Bint Abdulrhman University, Zagazig, Egypt | ||
| چکیده | ||
| Background: Neoadjuvant chemotherapy (NAC) grants a modest survival benefit in localized muscle-invasive bladder cancer (MIBC). We evaluated the pathological response and survival outcome after NAC in stage II and IIIA MIBC and their correlation with body mass index (BMI). Method: Our retrospective study included stage II (T2 N0) and IIIA (T3 N0, T4 N0, T1-4 N1) MIBC. They received NAC followed by radical cystectomy. The patients were categorized into level I: a BMI of 18.5 – 24.9 kg/m2, level II: a BMI of 25-29.9 kg/m2, and level III: a BMI of ≥ 30 kg/m2. Results: 103 patients with localized MIBC were included. The median age was 63 years; 35 patients (34.0%) belonged to level I, 40 patients (38.8%) belonged to level II, and 28 patients (27.2%) belonged to level III. Smoking status was more common in level II (51.0%) and level III (36.7%) (P < 0.001). Only 18 patients had ECOG PS 2, all belonging to level III (P < 0.001). After NAC, the pCR was 34.3%, 25%, and 10.7% of level I, level II, and level III (P = 0.03), respectively. Of 19 patients who passed away, 10 patients belonged to level III and 6 patients belonged to level II (P = 0.007). For level I, level II, and level III, the disease-free survival was 23.2 months, 12.7 months, and 10.7 months and the overall survival was 61.9, 52.3, and 28.7 months, respectively. Conclusion: Obesity and overweight could be predictive and prognostic markers in localized MIBC. These factors are associated with low pCR after NAC, poor disease-free survival, and overall survival. | ||
| کلیدواژهها | ||
| Urinary bladder neoplasms؛ Body mass index؛ Neoadjuvant chemotherapy | ||
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